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Connection Found between Celiac Disease and Hashimoto's Thyroiditis
In the study, 104 individuals with Hashimotos Thyroiditis were tested for immunoglobulin A anti-transglutaminase (tTG) antibodies, IgA anti-endomysial antibodies (EMA) and HLA-DQ typing. Those who tested positive for any of the serological tests were given an intestinal biopsy.
Sixteen patients (15%) showed positive celiac serology and five patients clear villous atrophy were diagnosed with celiac disease (4.8%; 95% CI 0.7-8.9). All five patients diagnosed with celiac disease, and 53 patients with Hashimotos thyroiditis (50%; 95% CI 43-62), showed the presence of HLA-DQ2 (and/or -DQ8).
In a separate test within the study, 184 Individuals with known celiac disease were given a serological test for thyroglobulin and thyroid peroxidase Antibodies, after first being given thyroid biochemical, a thyroxine-free thyroid stimulating hormone.
39 patients (21%) showed positive thyroid serology. According
to thyroid biochemistry results, ten patients showed euthyroidism (5%;
95% CI 2-9), seven showed sub-clinical hypothyroidism (3.8%; 95% CI 1.8-7.6),
and 22 patients showed overt hypothyroidism, Hashimotos
thyroiditis (12%; 95% CI 8-16). Furthermore, four patients with celiac
disease had Graves disease (2%; 95% CI 0.8-5) and one patient had
The study concludes that there is a clear association between Hashimotos thyroiditis and celiac disease. Accordingly, it is recommended that patients with Hashimotos thyroiditis be screened for celiac disease and that patients with known celiac be screened for Hashimotos thyroiditis.
World Journal of Gastroenterology 2007; 13(10).health writer who lives in San Francisco and is a frequent author of articles for Celiac.com.
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Jefferson Adams is a freelance writer living in San Francisco. His poems, essays and photographs have appeared in Antioch Review, Blue Mesa Review, CALIBAN, Hayden's Ferry Review, Huffington Post, the Mississippi Review, and Slate among others.
He is a member of both the National Writers Union, the International Federation of Journalists, and covers San Francisco Health News for Examiner.com.View all articles by Jefferson Adams