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Celiac Disease Death Rates Increase Dramatically for the Undiagnosed and Untreated
Lancet 2001; 358: 356-61
Celiac.com 08/10/2001 - In line with past studies on the mortality rate of people with celiac disease, the results of a new study conducted by Dr. Giovanni Corrao (Cattedra di Statistica Medica, UniversitĂ di Milano-Bicocca, 20126 Milano, Italy), et. al., indicate that the death rate among people with celiac disease is double that of the normal population. The prospective cohort study examined 1,072 adults who were diagnosed with celiac disease between 1962 and 1994, and their 3,384 first-degree relatives. The mortality rates by 1998 among both groups were compared to that of the normal population.
Their findings show that 53 people in the celiac disease group died compared with the 25.9 deaths that were expected (Standardized Mortality Ratio - SMR). Unlike past studies, however, this one also looked for different patterns of clinical presentation of the disease. For example, the results indicate that within three years of diagnosis there was a significant increase in the mortality rate for those who presented symptoms of malabsorption. This same increase was not seen in those who were originally diagnosed because of minor symptoms, or via an antibody screening. The SMR also increased when there was a delay in diagnosis, and when a gluten-free diet was not followed. Non-Hodgkin lymphoma was the main cause of death, and no excess in mortality rate was seen in the groups first-degree relatives.
Conclusion: Prompt diagnosis and dietary treatment will decrease the mortality rate of people with celiac disease. More studies are needed regarding asymptomatic people with celiac disease and their risk of intestinal lymphoma.
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Can Better Biopsy Practices Improve Celiac Diagnosis in Children?
Researchers don't have any solid idea about how common cases of seronegative celiac disease might be, but many feel strongly that rates of seronegative celiac disease are underestimated in children, and may result in misdiagnosis of celiac cases.... [READ MORE]
Blood Tests Different in Patients with Gluten Sensitivity Than in Those with Celiac Disease
Gluten sensitivity has recently been added to the spectrum of gluten-related disorders, but precise diagnostic markers do not yet exist.... [READ MORE]
The Use of Monoclonal Antibodies to Detect Gluten in Foods
The intestinal inflammation that arises when people with celiac disease consume wheat, rye or barley occurs when HLA-DQ2-restricted CD4+ T-cells recognize peptides derived from gluten in the food.... [READ MORE]
Celiac Disease in the Year 2000: Exploring the Iceberg
Abstract for the Italian study:
Catassi C; Ratsch IM; Fabiani E; Rossini M; Bordicchia F; Candela
F; Coppa GV; Giorgi PL
Coeliac Disease in the Year 2000: Exploring the Iceberg [see
Department of Pediatrics, University of Ancona, Italy.... [READ MORE]
In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I foundedĂ‚Â The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.View all articles by Scott Adams
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