No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Do Adult Celiacs with Pancreatic Insufficiency Require Long-Term Enzyme Supplements?


New research on pancreatic insufficiency and celiac disease.

Celiac.com 06/18/2010 - One of the conditions associated with celiac disease is called exocrine pancreatic insufficiency. A previous study showed that exocrine pancreatic insufficiency is the trigger for about one in three (20/66) cases of current or persistent diarrhea in adults with celiac disease. Of these 20 patients, 19 showed initial improvement with pancreatic supplementation.

However, at this point, there are no longitudinal studies on exocrine pancreatic insufficiency in the medical literature. A research team set out to rectify that by conducting their own longitudinal study. The team included Kate E. Evans, John S. Leeds, Stephen Morley, and David S. Sanders.

Over the next four years, the team conducted prospective follow-up checks on the 20 patients who received therapy for exocrine pancreatic insufficiency. The team assessed gastrointestinal symptoms, dietary adherence, celiac antibody status, and dose of enzyme supplementation. They repeated titters for fecal elastase-1 (Fel-1) to reassess exocrine pancreatic function.

The team was able to review 19 of the 20 patients; one patient had died. The group averaged 59.7 years of age. Seven subjects were male. On average, patients suffered from celiac disease for 13.2 years.

Ads by Google:

Eleven out of nineteen patients continued on enzyme supplementation, with average doses of 45,000 units of lipase per day. Only one of the eleven patients reported no reduction in symptoms, while eight of the 19 patients had discontinued the supplements after their diarrhea abated.

The entire group showed a substantial increase in Fel-1 levels over time, with median values of 90 lg/g at zero months, 212 lg/g at six months, and 365 lg/g at follow-up of 45–66 months (p/0.0001).

Fecal elastase-1 is helpful in spotting exocrine pancreatic insufficiency in adult celiac patients with diarrhea.

Results of the team's longitudinal survey indicate that that patients with celiac disease can end pancreatic enzyme supplementation as symptoms improve.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


There aren't any gluten free nut brand in my country. Are nuts with shells like peanuts,walnuts sold in stores without package gluten free? Do they add anything else to them?

Supplementation with Natural Vitality Stress & Energy, will help a lot it is a sublingual B-vitamin pretty much. I use it with the Neurological support from the same company and Natural Vitality Calm Magnesium. These along with a diet in foods that help with mood like snacking on cocoa nibs, hemp...

Hey everyone... newbie here. I have a few questions but first my history: Dx with Hashimoto's in 2003. Had SEVERE adverse reaction to T4 no idea why but then switched to T3. But T4 opened a can of worms. Immediately after starting T4 had digestive issues. Aften a few years tried gluten free....

My 7-year-old has been complaining of constant itchiness and a skin crawling sensation for the past five months, but has no external rash or symptoms. It seems to get worse at night, although that may be because it's more difficult to distract herself at bedtime. We've tried switching shampoo...

Wow! It sounds like you are going through a lot right now. Most of our dinners at home are gluten free and my kids eat the food just fine. It does take a bit more planning and you have to make more things from scratch. Our favorite dinners are tacos (serve on corn tortillas), red beans and...