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Gluten Sensitivity May Trigger Sensory Ganglionopathy


New study on gluten sensitivity sensory ganglionopathy.

Celiac.com 10/28/2010 - A team of researchers recently found that gluten sensitivity can play a role in triggering a certain type of neurologic dysfunction, called sensory ganglionopathy, and that the condition may respond to a strict gluten-free diet.

The team conducted a retrospective observational case study on 409 patients with different types of peripheral neuropathies, including seventeen patients with sensory ganglionopathy and gluten sensitivity.

The research team was made up of M. Hadjivassiliou, MD, D.G. Rao, MD, S.B. Wharton, PhD, D.S. Sanders, MD, R.A. Grünewald, DPhil, and A.G.B. Davies-Jones, MD. They are affiliated variously with the Departments of Neurology, Neurophysiology, Neuropathology, and Gastroenterology at Royal Hallamshire Hospital in Sheffield, UK.

Neurological issues are common in people with celiac disease and gluten-sensitivity. On eof the most common neurological issues in these people is called peripheral neuropathy. The most common type of neuropathy seen in people with gluten sensitivity is sensorimotor axonal.

The team reviewed data on 409 patients with different types of peripheral neuropathies. All of these patients had been followed for a number of years in dedicated gluten sensitivity/neurology and neuropathy clinics.

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Fifty-three of these patients (13%) showed clinical and neurophysiologic evidence of sensory ganglionopathy. Seventeen of these fifty-three patients (32%) showed positive blood screens for gluten sensitivity.

The median age of those with gluten sensitivity was 67 years, with symptom onset starting at 58 years on average.

Seven of those with positive blood screen evidence gluten sensitivity showed enteropathy upon biopsy. Fifteen patients went on a gluten-free diet, resulting in stabilization of the neuropathy in eleven of the fifteen.

The remaining four patients did not follow the gluten-free diet and their conditions worsened, as did the two patients who declined dietary treatment. Autopsy tissue from three patients showed inflammation in the dorsal root ganglia with degeneration of the posterior columns of the spinal cord.

These results led the team to conclude that sensory ganglionopathy can result from gluten sensitivity and may respond positively to a strict gluten-free diet.

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4 Responses:

 
Pattymack
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
01 Nov 2010 8:04:37 AM PDT
Good to see research and articles on gluten sensitivity as a separate (from CD) condition.

 
Rosemary Melcher
Rating: ratingfullratingemptyratingemptyratingemptyratingempty Unrated
said this on
02 Nov 2010 9:55:38 AM PDT
What does ganglionopathy mean? What are the symptoms? I am 78, diagnosed with celiac 6 years ago and have trouble enough understanding a gluten-free diet, let alone medical words. Can you help an elderly declining brain? Is a declining brain a symptom of celiac?

 
Mary McBender

said this on
27 Jun 2013 2:45:59 PM PDT
It looks like Rosemary is still waiting for an answer, after almost 3 years. Shame on the authors and the website for not caring about feedback and questions. I think the question is quite legitimate! Or is this forum only for MDs?

 
Gryphon
( Author)
said this on
27 Jun 2013 4:08:28 PM PDT
This is not a forum - we request that people not post questions in comments specifically for this reason. We have a forum for such questions: http://www.celiac.com/gluten-free/




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Ironic, We went entirely gluten-free in our home after 2016 for how bad my neurological , joints, mood gets now in addition to my former gi, skin, and other issues . My son shows signs of my early symptoms and voluntarily went off gluten, corn, and milk like me as he did his own food like di...

Funny though, my brother and I were just discussing this. He has celiac and both his son and him are gene positive. Both were TTG/EMA negative but never tested for DGP. My brother had damage on endoscopy. They have not scoped his son. He feels his son is symptomatic but not his daughter. I ...

It might generate based on traffic searches or posts etc. My guess. I read them and respond because I wasn't on here as a member in 2012. I only use to visit then. So it's new to me V. happy friday ?

Just saying her TTg was 0 & her IgA was 27 doesn't tell us anything. Every lab can have different values so we need the reference ranges not just the results. Can you look back at the lab report & get those & post them please? Did they tell you she MUST be eating gluten every single day unti...

When the doc did the endoscopy, did he take biopsies? How many? From what locations? Get your records!!!! If he didn't take biopsies for celiac disease then he can NOT say you don't have it. 99% of the time, villi damage can not be SEEN by the GI doc during the endoscopy. And yes, the doc has no ...