No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter




Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Gut Bacteria Differs in Gluten-free Celiac Patients with Persistent Symptoms

Celiac.com 02/09/2015 - Do you suffer from persistent celiac symptoms in spite of following a strict gluten-free diet and having normal small bowel mucosa? Many celiac patients do. Moreover, typical explanations, such as accidental gluten-intake or the presence of other gastrointestinal disease, do not account for all of the symptoms in these patients.

Photo: CC--Quin DombrowskiRecent studies have suggested that changes in intestinal microbiota are associated with autoimmune disorders, including celiac disease.

A team of researchers recently set out to determine if abnormal intestinal microbiota may in fact be associated with persistent gastrointestinal symptoms in gluten-free celiac disease patients. The research team included Pirjo Wacklin PhD, Pilvi Laurikka, Katri Lindfors PhD, Pekka Collin MD, Teea Salmi MD, Marja-Leena Lähdeaho MD, Päivi Saavalainen PhD, Markku Mäki MD, Jaana Mättö PhD, Kalle Kurppa MD, and Katri Kaukinen MD.

They are variously associated with the Finnish Red Cross Blood Service, Helsinki, Finland; School of Medicine, University of Tampere, Tampere, Finland; the Tampere Centre for Child Health Research at the University of Tampere and Tampere University Hospital in Tampere, Finland; the Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, in Tampere, Finland; the Department of Dermatology at Tampere University Hospital in Tampere, Finland; the Research Programs Unit of the Immunobiology, and Department of Medical Genetics at the Haartman Institute of the University of Helsinki in Helsinki, Finland; the Department of Internal Medicine at Tampere University Hospital in Tampere, and with Seinäjoki Central Hospital in Seinäjoki, Finland,

The team used 16S rRNA gene pyrosequencing to analyze duodenal microbiota in 18 gluten-free celiac patients suffering from persistent symptoms, and 18 gluten-free celiac patients without symptoms.

Ads by Google:

All celiac patients had been following a strict gluten-free diet for several years, and had restored small bowel mucosa and tested negative for celiac autoantibodies.

The team rated symptoms using the Gastrointestinal Symptom Rating Scale, and found that gluten-free celiac disease patients with persistent symptoms had different duodenal bacteria than celiac patients without symptoms.

Gluten-free celiac patients with persistent symptoms had a higher relative abundance of Proteobacteria (P=0.04) and a lower abundance of Bacteroidetes (P=0.01) and Firmicutes (P=0.05). Moreover, they had a much narrower range of bacteria types in their guts.

The discovery that dysbiosis of microbiota is associated with persistent gastrointestinal symptoms in gluten-free celiac patients offers a new avenue of treatment for such patients.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
dappy
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
16 Feb 2015 6:58:06 AM PDT
I had to go on a daily probiotic even after going completely GF. Within a week, symptoms came under control and generally disappeared.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Thanks for the feedback everyone. I've been gluten free for just over a year and have been pretty good about staying away from processed foods and bread substitutes. I was just really jonesing for my grandma's banana pudding. Zanthan gum, soy and corn don't bother. So Googling the other two thing...

Omg.

if you have celiac and you eat gluten, you will feel terrible and do damage to your body. there isn't any 'morning after' (for lack of a better term) tried and true remedy. if i am accidently glutened (and i am insanely careful, so this does not happen often anymore) i find that drinking plenty...

My mistake... HUGE Oops... She hasn't been diagnosed with anything as of yet. I couldn't remember the name so I googled and DH came up. Well that was wrong.... it is Keratosis pilaris she has. i just really don't want her to get to 20 years old and finally become allergic to lactose lik...