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What Exactly is Ultra-short Celiac Disease?

Celiac.com 04/06/2016 - Ultra-short celiac disease (USCD) is a type of celiac disease in which villous atrophy limited to the patient's duodenal bulb.

Photo: CC--GeorgeThe clinical effects of of ultra-short celiac disease, or gluten-sensitive enteropathy with villous atrophy limited to the duodenal bulb (D1) have not been delineated in adults with celiac disease.

A team of researchers recently evaluated the sensitivity of D1 biopsy analysis in celiac disease detection, the number and sites of biopsies required to detect USCD, which is villous atrophy limited to the duodenal bulb, and the clinical characteristics of USCD.

The researchers included Peter D. Mooney, Matthew Kurien, Kate E. Evans, Eleanor Rosario, Simon S. Cross, Patricia Vergani, Marios Hadjivassiliou, Joseph A. Murray, and David S. Sanders. They are variously affiliated with the University of Sheffield, UK, and with the Departments of Gastroenterology, Neurology and Histopathology at Royal Hallamshire Hospital, Sheffield, UK.

For their evaluation, they conducted a prospective study of 854 women and 524 men, averaging about 50 years of age, who underwent endoscopy at a tertiary medical center in the United Kingdom from 2008 through 2014. The team collected routine duodenal biopsies from D1 and D2.

They collected quadrantic D1 biopsies from 171 consecutive patients with a high suspicion of celiac disease. This group averaged about age 46 years of age, and was 64% female.

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Using biopsy analysis, they then compared the clinical data from patients diagnosed with USCD against data from patients with conventional celiac disease damage beyond D1, and against data from a control group of patients without celiac disease. They then compared numbers of intraepithelial lymphocytes (IELs) and immune phenotypes between D1 vs D2 in patients with celiac disease.

Of the 1378 patients assessed, they diagnosed 268, nearly 20%, with celiac disease; 9.7% of these patients had villous atrophy confined to D1 (USCD, P<.0001). By collecting just a single additional biopsy from any D1 site, the sensitivity of celiac disease detection increased by about 10% (P<.0001).

Overall, patients with USCD were younger, had lower levels of tissue transglutaminase antibody, and suffered less frequently with diarrhea than patients with conventional celiac disease. Both USCD and control patients had far fewer cases ferritin deficiency or folate deficiency than patients with conventional celiac disease. Patients with celiac disease averaged 50 IELs/100 enterocytes in D1, and 48 IELs/100 enterocytes in D2.

The phenotype of IELs from patients with D1 celiac disease was no different from those of patients with D2 celiac disease.

This study shows that the collection of a single additional biopsy from any site in the D1 intestine increases the sensitivity of detection for celiac disease by about 10%.

Patients with USCD may have early-stage or limited celiac disease, with a mild clinical phenotype, and fewer nutritional deficiencies. This is an important thing to keep in mind when diagnosing and treating such cases.

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3 Responses:

 
Dennis Wales
Rating: ratingfullratingemptyratingemptyratingemptyratingempty Unrated
said this on
11 Apr 2016 10:04:26 PM PDT
I am sure those with a doctorate would rate this article as being excellent. I am sure that there are many celiac sufferers who are interested in learning more about their condition but are put off reading articles which are written in gobledy gook language. Hasn't anyone, during your climb through all the degrees you may have attained, told you to 'keep it simple' if you want it read.
Now it is true that you should write for your selected audience and maybe you have done this, unfortunately you are probably only reaching those who already know what you have written.
When people speak or write to prove their knowledge, they do it for their own ego.
Keep it simple sugar and we'll all follow you.

 
Wendellyn
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
12 Apr 2016 12:26:38 AM PDT
Holy cow!!! Can you give this in common speak? Nothing is more difficult than trying just to translate all this info.

 
angela
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
12 Apr 2016 10:52:00 PM PDT
I totally agree! My poor head is aching. It's too hard to understand such technical terms. Wish it was more understandable. In way more simple terms.




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