No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Does the Preferential Expression of HLA-DQ2.5 Genes in Celiac Disease Impact T Cell Response?


Photo: CC--Money Images

Celiac.com 05/30/2016 - People with HLA genes have the highest risk factor for developing autoimmune disorders. The vast majority of people with celiac disease carry the HLA DQA1*05 and DQB1*02 alleles, both of which encode the DQ2.5 molecule.

A research team recently set out to examine the implications for anti-gluten T cell response of the preferential expression of HLA-DQ2.5 genes associated with celiac disease with respect to non-predisposing HLA genes. The research team included L Pisapia, A Camarca, S Picascia, V Bassi, P Barba, G Del Pozzo, and C Gianfrani. They are variously affiliated with the Institute of Protein Biochemistry-CNR, the Institute of Genetics and Biophysics-CNR in Naples, Italy, and the Institute of Food Sciences-CNR in Avellino, Italy.

In order to activate pathogenic CD4+ T lymphocytes, that is, to trigger active celiac disease, it is necessary for the body to form complexes between DQ2.5 and gluten peptides on antigen-presenting cells (APCs). It is widely accepted by clinicians that the DQ2.5 genes establish the different intensities of anti-gluten immunity, depending on whether they are in a heterozygous or a homozygous configuration, that is, whether both genes are activated, or only one gene is activated.

Ads by Google:

The research team's recent study shows that, in celiac patients, HLA DQA1*05 and DQB1*02 gene expression is much higher than expression of non-celiac-associated genes. This, in turn, impacts protein levels and causes a comparable cell surface exposure of DQ2.5 heterodimers between DQ2.5 homozygous and heterozygous celiac patients. As a consequence, the magnitude of the anti-gluten CD4+ T cell response is strictly dependent on the antigen dose, and not on the DQ2.5 gene configuration of APCs.

These findings are important, because they support the idea that the expression of DQ2.5 genes is an important risk factor in celiac disease.

The preferential expression of DQ2.5 alleles observed in this study offers a new explanation of why these genes are so frequently associated with celiac disease and with other autoimmune disorders.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


That's terrible. I've been wondering why you haven't been around last few days. I Should have remembered your con. I'm so sorry it wasn't what you were hoping for. We all tend to make mistakes when we're excited about stuff, makes our brains go a bit wonky. hope your dads mouth wasn't dirty ...

Yum, what's wrong with eggs and bacon? i just got some gluten-free granola yesterday that I tried this morning and it's not too bad but it's got gluten-free oats. Can you do oats?

Before being diagnosed I was almost a 100% Raisin Brain cereal eater. So I switched to Bakery on Main, Gluten Free Granola. I was having nausea, lose stool, and would get dizzy about 30 min. after eating it. Doc said to switch to Soy milk. That didn't really help either. Now I just put...

My Dr. also said that about thyroid! The appt went well. She is sending me for endoscopy and colonoscopy. She said to eat gluten one week before, which according to everything else, is not correct. My concern now is this- I didn't eat much anyhow, but I can't imagine eating 4 pieces o...

Hi, everyone. I haven't been diagnosed with Celiac disease, so I hope it's okay for me to post here. I'm a 21-year-old female who has been struggling with some chronic symptoms for about a year now. Out of nowhere, I started losing weight. To date, I've lost upwards of 70 pounds. I was ...