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Do Flat Mucosa Always Mean Celiac Disease?


Photo: CC--Les Chatfield

Celiac.com 06/08/2016 - Sometimes, certain cases can stand out and grab the attention of clinicians or researchers. Such is the case of a 62-year-old woman who was suffering from severe malabsorption, and diagnosed with celiac disease based on the findings of flat, small intestinal mucosa and HLA-DQ2 positivity, although celiac blood tests were negative.

A team of researchers questioned the diagnosis, because the woman showed no clinical or histological improvement after a long period of strict gluten-free diet.

The research team included U Volta, MG Mumolo, G Caio, E Boschetti, R Latorre, F Giancola, P Paterini, and R De Giorgio. They variously are affiliated with the Department of Medical and Surgical Sciences at the University of Bologna, and with the Gastroenterology Unit in the Department of Gastroenterology at the University of Pisa in Italy.

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Based on the detection of enterocyte autoantibodies, the team found that the correct diagnosis for the woman was autoimmune enteropathy. After appropriate immunosuppressive treatment, the woman experienced the disappearance of all symptoms, and a complete recovery.

Based on this case, the team notes that doctors should consider autoimmune enteropathy in the differential diagnosis of malabsorption with severe villous atrophy, including those cases with negative celiac-related serology.

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1 Response:

 
Rita
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
13 Jun 2016 3:00:15 PM PST
My doctor thought I was noncompliant and I thought I was being poisoned by restaurants when I traveled. Turned out that I was allergic to Xanthan Gum -- gave me the same cramps & diarrhea as grains and gluten. I don't see this mentioned very often.




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I have had rolling food intolerance issues and stuff crop up for years....but this time it was seemly triggered by a cold. I got a cold this weekend standard fever, stuffy nose, coughing gunk up, head pressure, random dizzy spells etc. Anyway I was eating on my chia seed rotation before getting ...

Thinking I saw this earlier on another post....anyway I do have a thought on this. I get little blood blisters and sores in my mouth, and on my tongue from things I ended with allergies to. With celiac being a autoimmune disease it can sometimes effect your immune system, like make you more prone...

Hi been diagnosed as celiac over 2 years ago have a bad episode at present with tongue and swollen sore nose looks like little blisters has anyone else had these symptoms and if so what made it stop please any advise would be fab

As mentioned above is true, I used to love fruit I got other AI diseases and some other issues that prevent me from eating fruit but I am a freak lol. ANYWAY since your new I will link you the newbie 101 threads. I would be more concerned with hidden gluten in your old condiment filled with crum...

Some people can be asymptomatic, I know a few celiacs like this. Needless to say, this doesn't mean that gluten isn't still wreaking havoc in your intestines.