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What's the Current Status of Celiac Disease Drug Development?


New understanding about celiac disease could lead to drug breakthroughs. Photo: CC--Tom Hart

Celiac.com 07/25/2016 - Celiac disease is one of the most common immune-mediated diseases. Often, a gluten-free diet does not fully control celiac symptoms and disease activity.

Even though no new therapies have been approved, a growing effort, coupled with a rapidly expanding knowledge of the regulatory pathway could soon lead to new breakthroughs.

A team of researchers recently reviewed the epidemiology, pathophysiology, and current treatment paradigm for celiac disease. The researchers were M Wungjiranirun, CP Kelly, and DA Leffler, both of the Division of Gastroenterology at the Celiac Center of Beth Israel Deaconess Medical Center in Boston, Massachusetts, USA.

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They also reviewed the major types of therapies being proposed for celiac treatment, and expounded broadly upon what is known, and what can be predicted concerning the regulatory pathway for approval of a new celiac disease treatment. In the near future, increasingly numerous and diverse therapy options will enter clinical trials. The desired result will be the first approved agents targeting celiac disease treatment outside of a gluten-free diet.

The team notes that, though things like biopsies and blood tests will always be important in therapeutic clinical trials, there is not currently enough evidence to link them with improved patient outcomes, which is required as a baseline for drug approval. This means that patient-reported outcomes will likely be primary end points in Phase III celiac disease trials for some time to come.

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Please re-test the board...I believe that the issues should be fixed. Please let me know...and thank you!!!

Are these safe? The ingredients are:. Whole grain oats, sugar, canola oil, rice flour, honey, salt, brown sugar syrup, baking soda, soy lecithin, natural flavor. I am new at this, but nothing says no to me. Am I wrong?

Love bacon and eggs but don't think it would be a good idea to eat it everyday Not sure about oats. I didn't handle KIND Raspberry Granola (w/oats) well. But that was when I was adding milk.

I feel your pain. Gluten free and corn free is difficult. I eat Erewhon rice Crisps or Barbara's makes a rice crisp cereal as well. You can also try yogurt. Read the ingredients some have corn syrup or corn starch. Just an fyi for you high fructose corn syrup does not contain any corn.

That's terrible. I've been wondering why you haven't been around last few days. I Should have remembered your con. I'm so sorry it wasn't what you were hoping for. We all tend to make mistakes when we're excited about stuff, makes our brains go a bit wonky. hope your dads mouth wasn't dirty ...