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Celiac Disease Vaccine Set to Begin Full Human Trials


Celiac disease vaccine trials will start in Australia in late 2016. Photo: CC--Corey Leopold

Celiac.com 07/19/2016 - The world's first vaccine aimed at curing celiac disease is slated to begin full trials later this year, and residents of the Australian state of Victoria will be among the first humans to give it a try against celiac disease.

The vaccine, called Nexvax2, was developed by Australian scientist Dr Bob Anderson, and is aimed at giving celiac patients a chance to overcome their immune reaction to the gluten found in products containing wheat, rye and barley. Nexvax2 aims to de-sensitise patients to three peptides contained in gluten that trigger a damaging reaction in their immune system.

Previous trials on 150 patients from Melbourne, Perth, Adelaide, Brisbane and Auckland were aimed at finding a safe dosage rather than assessing its ability to beat celiac disease. Results from those favorable earlier trials were released in May, and Dr Anderson says that the larger phase II study, also being undertaken in the US and Europe, will assess how well the vaccine works against celiac disease.

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Dr Anderson first identified the peptides triggering coeliac disease and began developing the vaccine while working at Melbourne's Walter and Eliza Hall Institute, before travelling to Boston for six weeks as part of a sister city arrangement through the City of Melbourne, where he made contact with ImmusanT to further the discovery.

This is certainly exciting news for people with celiac disease, many of whom may benefit from such treatment.

Stay tuned for news on the progress of these trials.

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15 Responses:

 
Jeanne Burge
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said this on
21 Jul 2016 10:39:11 AM PDT
I would gladly volunteer for the trials in the US. Hope this works!

 
Anon
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said this on
22 Jul 2016 9:38:29 AM PDT
Hell, I'll fly to AU to volunteer :)

 
MM_AK
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said this on
26 Jul 2016 4:10:52 PM PDT
Let's book a plane! I wouldn't go back to a gluten diet but with this the contamination wouldn't be a big risk/scare when in public settings. I've worked with vaccines first hand, I know most are very safe; I'd jump on this in a heart beat.

 
B E
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said this on
25 Jul 2016 1:06:57 PM PDT
Wow this is amazing!!!

 
Doc
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said this on
25 Jul 2016 8:37:44 PM PDT
I wouldn't forego a gluten free diet after being vaccinated. I would hope that the vaccine would deter the effects of living in a non-GF household.

 
Sandy
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said this on
26 Jul 2016 4:32:57 AM PDT
Nope, no vaccines of any kind!

 
Evan
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said this on
26 Jul 2016 11:05:10 AM PDT
So, never mind all the dangerous effects that wheat gluten has and forget about the pesticide? Sorry, but after being gluten free for over 3 years I am not sure why anyone would want to go back to the stuff.

 
Maggie
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said this on
26 Jul 2016 11:37:56 AM PDT
I would gladly volunteer!!!!

 
Roberta
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said this on
26 Jul 2016 12:15:18 PM PDT
That would be so great! I'm keeping my fingers crossed that it works well with no negative side effects.

 
Busby
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said this on
26 Jul 2016 12:47:47 PM PDT
This sounds very interesting. Remember, too, that you can eat organic, non-GMO, so if it were possible to eat gluten, it might not be necessary to ingest (other) poisons.

 
Dave
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said this on
28 Jul 2016 10:32:47 AM PDT
No mention of age restrictions. With 2 Grandchildren suffering from celiac, it is a constant problem when taking them somewhere.

 
A Y
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said this on
08 Aug 2016 5:03:52 PM PDT
But will it also take care of the cross reaction to other foods?

 
Brent
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said this on
11 Aug 2016 2:22:20 AM PDT
Heres hoping they make it work. I would like my freedom to eat and enjoy food again. Ate out for lunch today and reminded me of how bland gluten free is. This vaccine I hope gets rid of all the worry of travelling.

 
Debbie
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said this on
01 Sep 2016 12:52:56 AM PDT
That would be great, I would love to be involved in the human trials!!

 
Akhter
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said this on
16 Apr 2017 11:51:26 PM PDT
This is a great news who suffer that disease. I would try this on my son Abdullah, who is now 11 years old and he is fighting with this disease.




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@cyclinglady thanks for checking in Restricted diet didn't do much. Still had some VA last time they checked. Heath still otherwise fine, so RCD remains unlikely. My sxs kick in lockstep with life stress, so that kind of points to some general IBS stuff on top of celiac disease. Very doubtful I'm getting any gluten in, but fingers crossed my system is just a little hyper-vigilant, as I ponder on this thread.

I have always noticed that the table wine in Europe is pretty damn good! I am a wine lover and so is my husband but he does like his Green's beer.

The reason they set the limit at 20ppms is that through scientific study, they have proven that the vast majority of people with Celiac Disease do not have an autoimmune reaction to amounts below that......it is a safe limit for most. Also, just because that limit is set at 20ppms, does not mean that gluten-free products contain that amount of gluten. Testing for lower levels becomes more expensive with each increment down closer to 0-5ppms, which translates into higher priced products. Unless you eat a lot of processed gluten-free food, which can have a cumulative affect for some, most people do well with the 20ppm limit.

I'm in the Houston area so I'm assuming there are plenty of specialists around, though finding one that accepts my insurance might be hard. This might sound dumb, but do I search for a celiac specialist?? I'm so new to this and want to feel confident in what is/isn't wrong with my daughter. I'm with you on trusting the specialist to know the current research.

Hi VB Thats sounds like a good plan. Would it help to know that a frustrating experience in seeking diagnosis isn't unusual With your IGG result I'm sure a part of you is still wondering if they are right to exclude celiac. I know just how you feel as I too had a negative biopsy, but by then a gluten challenge had already established how severely it affected me. So I was convinced I would be found to be celiac and in a funny way disappointed not to get the 'official' stamp of approval. Testing isnt perfect, you've already learned of the incomplete celiac tests offered by some organisations and the biopsy itself can only see so much. If you react positively to the gluten free diet it may mean you're celiac but not yet showing damage in a place they've checked, or it may be that you're non celiac gluten sensitive, which is a label that for a different but perhaps related condition which has only recently been recognised and for which research is still very much underway. We may not be able to say which but the good news is all of your symptoms: were also mine and they all resolved with the gluten free diet. So don't despair, you may still have found your answer, it just may be a bit wordier than celiac! Keep a journal when you're on the diet, it may help you track down your own answers. Best of luck!