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Celiac Disease Vaccine Set to Begin Full Human Trials


Celiac disease vaccine trials will start in Australia in late 2016. Photo: CC--Corey Leopold

Celiac.com 07/19/2016 - The world's first vaccine aimed at curing celiac disease is slated to begin full trials later this year, and residents of the Australian state of Victoria will be among the first humans to give it a try against celiac disease.

The vaccine, called Nexvax2, was developed by Australian scientist Dr Bob Anderson, and is aimed at giving celiac patients a chance to overcome their immune reaction to the gluten found in products containing wheat, rye and barley. Nexvax2 aims to de-sensitise patients to three peptides contained in gluten that trigger a damaging reaction in their immune system.

Previous trials on 150 patients from Melbourne, Perth, Adelaide, Brisbane and Auckland were aimed at finding a safe dosage rather than assessing its ability to beat celiac disease. Results from those favorable earlier trials were released in May, and Dr Anderson says that the larger phase II study, also being undertaken in the US and Europe, will assess how well the vaccine works against celiac disease.

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Dr Anderson first identified the peptides triggering coeliac disease and began developing the vaccine while working at Melbourne's Walter and Eliza Hall Institute, before travelling to Boston for six weeks as part of a sister city arrangement through the City of Melbourne, where he made contact with ImmusanT to further the discovery.

This is certainly exciting news for people with celiac disease, many of whom may benefit from such treatment.

Stay tuned for news on the progress of these trials.

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17 Responses:

 
Jeanne Burge
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said this on
21 Jul 2016 10:39:11 AM PST
I would gladly volunteer for the trials in the US. Hope this works!

 
BW
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said this on
17 Aug 2017 12:15:41 PM PST
Me too! I volunteer, pick me!!!

 
Anon
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said this on
22 Jul 2016 9:38:29 AM PST
Hell, I'll fly to AU to volunteer :)

 
MM_AK
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said this on
26 Jul 2016 4:10:52 PM PST
Let's book a plane! I wouldn't go back to a gluten diet but with this the contamination wouldn't be a big risk/scare when in public settings. I've worked with vaccines first hand, I know most are very safe; I'd jump on this in a heart beat.

 
B E
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said this on
25 Jul 2016 1:06:57 PM PST
Wow this is amazing!!!

 
Doc
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said this on
25 Jul 2016 8:37:44 PM PST
I wouldn't forego a gluten free diet after being vaccinated. I would hope that the vaccine would deter the effects of living in a non-GF household.

 
Sandy
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said this on
26 Jul 2016 4:32:57 AM PST
Nope, no vaccines of any kind!

 
Evan
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said this on
26 Jul 2016 11:05:10 AM PST
So, never mind all the dangerous effects that wheat gluten has and forget about the pesticide? Sorry, but after being gluten free for over 3 years I am not sure why anyone would want to go back to the stuff.

 
Maggie
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said this on
26 Jul 2016 11:37:56 AM PST
I would gladly volunteer!!!!

 
Roberta
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said this on
26 Jul 2016 12:15:18 PM PST
That would be so great! I'm keeping my fingers crossed that it works well with no negative side effects.

 
Busby
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said this on
26 Jul 2016 12:47:47 PM PST
This sounds very interesting. Remember, too, that you can eat organic, non-GMO, so if it were possible to eat gluten, it might not be necessary to ingest (other) poisons.

 
Dave
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said this on
28 Jul 2016 10:32:47 AM PST
No mention of age restrictions. With 2 Grandchildren suffering from celiac, it is a constant problem when taking them somewhere.

 
A Y
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said this on
08 Aug 2016 5:03:52 PM PST
But will it also take care of the cross reaction to other foods?

 
Brent
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said this on
11 Aug 2016 2:22:20 AM PST
Heres hoping they make it work. I would like my freedom to eat and enjoy food again. Ate out for lunch today and reminded me of how bland gluten free is. This vaccine I hope gets rid of all the worry of travelling.

 
Debbie
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said this on
01 Sep 2016 12:52:56 AM PST
That would be great, I would love to be involved in the human trials!!

 
Akhter
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said this on
16 Apr 2017 11:51:26 PM PST
This is a great news who suffer that disease. I would try this on my son Abdullah, who is now 11 years old and he is fighting with this disease.

 
Kara
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said this on
05 Nov 2017 4:39:57 PM PST
Sign me up, if I have to take a shot everyday, 3 times a day, so it. I abhor needles. But stab away.




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In Celiac.com's Forum Now:


Some people, like me, never get a positive on the TTG (even on follow-up Testing) and I stated that some celiacs (10%) have negative tests results period. Your doctor is doing the colonoscopy. Ask him if he is going into the small intestine via that route.

Yep. Initially I had the full panel. DGP was the only positive and it's the only one my doctor orders now.

Well I wish mine was dia. earlier, I got all kinds of other food issues, and other auto immune disease that came up as complications. If you deal with and change over now you can prevent a even more limited diet. I was running a bucket list thinking I was going to die before my dia. I had slight ...

So, do they just test your DGP like they just test my TTG?

The only test I have had done is the TTG because that's what I had done initially after taking matters into my own hands and going to my local health fair. Celiac is so common they do that screening at our health fair. My number was so high that my doctor didn't order other labs and went straight...