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What's the Connection Between Gluten Sensitivity and Postural Tachycardia Syndrome?
Is gluten sensitivity connected with postural tachycardia syndrome? Photo: CC--Michael Mandlberg
Celiac.com 10/31/2016 - Responding to observations and reports that many patients with postural tachycardia syndrome (PoTS) adopt a gluten-free diet without medical consultation, a team of researchers recently set out to evaluate the prevalence of celiac disease and self-reported gluten sensitivity in patients with PoTS, and to compare the results against data from the local population.
The research team included HA Penny, I Aziz, M Ferrar, J Atkinson, N Hoggard, M Hadjivassiliou, JN West, and DS Sanders. They are variously affiliated with the Academic Department of Gastroenterology Departments of Cardiology, Radiology, and Neurology at Royal Hallamshire Hospital, and Upperthorpe Medical Centre in Sheffield, UK.
For their study, the team recruited 100 patients with PoTS to complete a questionnaire that screened for gluten sensitivity, related symptoms and dietary habits. They also screened patients for celiac disease. For comparison, they calculated local celiac prevalence from a total of 1,200 control subjects (group 1) and another 400 control subjects (group 2), frequency matched for age and sex, who completed the same questionnaire.
Overall, 4/100 (4%) patients with PoTS had serology and biopsy-proven coeliac disease. This was significantly higher than the local population prevalence of celiac disease (12/1200, 1%; odds ratio: 4.1, 95% confidence interval: 1.3-13.0; P=0.03). PoTS patients also had a higher prevalence of self-reported gluten sensitivity (42 vs. 19%, respectively; odds ratio: 3.1, 95% confidence interval: 2.0-5.0; P<0.0001).
This is the first study to show a possible connection between gluten-related disorders and PoTS. They note that a prospective study which examines this relationship further might promote better understanding and treatment of these conditions.
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Jefferson Adams is a freelance writer living in San Francisco. His poems, essays and photographs have appeared in Antioch Review, Blue Mesa Review, CALIBAN, Hayden's Ferry Review, Huffington Post, the Mississippi Review, and Slate among others.
He is a member of both the National Writers Union, the International Federation of Journalists, and covers San Francisco Health News for Examiner.com.View all articles by Jefferson Adams
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