Celiac.com 05/12/2022 - Recent studies suggest that KIR+CD8+ T cells could offer a path to controlling autoimmune diseases, such as “long COVID,” which emerge after viral infections.
Ly49+CD8+ T cells are a subset of CD8+ T cells that have shown immunoregulatory activity in mice. These cells can suppress myelin oligodendrocyte glycoprotein (MOG)–specific pathogenic CD4+ T cells through their cytolytic activity and thereby ameliorate experimental autoimmune encephalomyelitis (EAE). 
However, whether a similar CD8+ regulatory T cell subset exists in humans and whether its suppressive activity extends beyond autoimmune diseases to play a more general role in peripheral tolerance remains to be determined.
A team of researchers recently shared some relevant findings regard...

Celiac.com 08/14/2023 - Celiac disease is an autoimmune condition in which dietary gluten triggers inflammation in the intestine, which can result in damage to the intestinal lining. Researchers conducted a study to understand how gluten-specific CD4+ T cell activation causes intestinal damage through single-cell analysis of patients in different celiac disease states and healthy individuals.
The study revealed distinctive immune cell signatures in patients with untreated celiac disease, including elevated CD4+ follicular T-helper cells, regulatory T cells, and natural CD8+ αβ and γδ intraepithelial T cells (T-IELs). The presence of these activated intestinal T cell populations was associated with untreated, active, and potential celiac disease.
In response to gluten consumption, a ...

Celiac.com 09/11/2023 - Researchers recently carried out multiplexed-single cell analysis of intestinal and peripheral blood T cells from patients with celiac disease in different disease states as well as healthy controls. 
The research team included Adam Kornberg; Theo Botella; Christine S. Moon; Samhita Rao; Jared Gelbs; Liang Cheng; Jonathan Mille; Alyssa M. Bacarella; Javier A. García-Vilas; Justin Vargas; Xuechen Yu; Izabela Krupska; Erin Bush; Reuben Garcia-Carrasquillo; Benjamin Lebwohl; Suneeta Krishnareddy; Suzanne Lewis; Peter H. R. Green; Govind Bhagat; Kelley S. Yan; and Arnold Han.
Analysis of T Cells from Celiac Disease Patients at Different Stages
Celiac disease is an autoimmune disorder characterized by intestinal inflammation triggered by dietary g...

Celiac.com 11/05/2025 - Celiac disease is an immune condition in which eating gluten sets off inflammation that harms the lining of the small intestine. The current standard of care is a strict gluten-free diet, but many people still experience symptoms or worry about accidental exposure. This systematic review examined two emerging treatment ideas that act directly on the immune system: medicines that block an enzyme called transglutaminase 2, and approaches that boost or restore the calming arm of the immune system through cells known as regulatory T cells. The goal was to see whether these strategies can lessen damage in the gut, reduce symptoms, and improve everyday health.
Why These Two Targets Matter
Transglutaminase 2 helps the body repair tissue, but in celiac disease...