Celiac.com 05/07/2019 - What causes persistent symptoms in celiac patients who are following a gluten-free diet? Many people with celiac disease suffer from persistent symptoms, even with healthy intestinal mucosa, and while following a gluten-free diet.
A team of researchers recently set out to explore the role of dietary factors, distinct small-bowel mucosal immune cell types, and epithelial integrity in the perpetuation of gastrointestinal symptoms in gluten-free celiac disease patients.
The research team included Pilvi Laurikka, MD; Katri Lindfors, PhD; Mikko Oittinen, MSc; Heini Huhtala, MSc; Teea Salmi, MD, PhD; Marja-Leena Lähdeaho, MD; Tuire PhIlus, MD, PhD; Markku Mäki, MD, PhD; Katri Kaukinen, MD, PhD; and Kalle Kurppa, MD, PhD.
They are variously affiliated w...

Celiac.com 08/02/2021 - Researchers currently know very little about the causative molecular pathways underlying the development of celiac disease. A team of researchers recently set out to discover new aspects of celiac disease formation and development. To uncover new aspects of disease development, their team used microarrays to measure changes in gene expression of duodenal biopsies.
The team used cDNA microarrays representing 19,200 genes to compare gene expression profiles of duodenal biopsies from 15 celiac disease patients with Marsh III villous atrophy, along with seven control subjects with normal biopsies (Marsh 0). They also looked at the specific effect of gluten by comparing the expression profiles of Marsh III lesions of seven patients exposed to gluten with four pat...

Celiac.com 11/02/2021 - Lactobacillus strains L. plantarum HEAL9 and L. paracasei 8700:2 have shown anti-inflammatory properties by reducing the body's pro-inflammatory responses to antigens. 
Using a randomized double-blind placebo-controlled trial, a team of researchers recently set out to test the hypothesis that the two strains suppress ongoing celiac disease autoimmunity in genetically at risk children on a gluten-containing diet.
The research team included Åsa Håkansson; Carin Andrén Aronsson; Charlotte Brundin; Elin Oscarsson; Göran Molin; and Daniel Agardh. They are variously affiliated with the Department of Food Technology Engineering and Nutrition, Lund University in Lund, Sweden; and the The Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund...

Celiac.com 11/22/2021 - B cells have important antibody-independent functions and are now recognized as key players in autoimmune diseases traditionally thought to be T cell-mediated. However, researchers still don't have a good understanding of the role of B cells as antigen-presenting cells.
By studying the autoantibody response against the enzyme transglutaminase 2 in celiac disease, a research team set out to gain insight into the mechanisms controlling initiation of a T cell-mediated autoimmune condition.
The research team included Rasmus Iversen, Bishnudeo Roy, Jorunn Stamnaes, Lene S. Høydahl, Kathrin Hnida, Ralf S. Neumann, Ilma R. Korponay-Szabó, Knut E. A. Lundin, and Ludvig M. Sollid. They are variously affiliated with the KG Jebsen Coeliac Disease Research Centre, U...