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    Scott Adams
    Scott Adams

    By Scott Adams •

    Reaction to a Gluten Challenge

    Reviewed and edited by a celiac disease expert.

    The following post if from Karoly Horvath, M.D., Open Original Shared Link, who is one of the two directors of the celiac center at University of Maryland in Baltimore.

    Celiac.com Sponsor (A12):
    Q: Does that mean I could be getting damage without knowing it because I have no obvious reaction?

    A: Based on our studies a typical (biopsy proven flat mucosa, proved immune reactions to gluten) gluten intolerant patient does not react immediately with clinical symptoms for a gluten challenge (J Pediatr Gastroenterol Nutr 1989, 9:176-180). However, ingestion of GRAMS OF GLUTEN causes several changes in the intestine.

    • There is an accumulation of inflammatory cells
    • One cell type -so called mast cells- releases factors which factors in long-term damage the villi and they also release a factor which;
    • Increases the permeability -leakiness- of the intestine, which is a temporarily change after a single ingestion but may be permanent after repeat dietary mistakes.

    Karoly Horvath, M.D., Ph.D., Baltimore

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    Scott Adams
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    Scott Adams was diagnosed with celiac disease in 1994. Faced with a critical lack of resources, he dedicated himself to becoming an expert on the condition to achieve his own recovery.

    In 1995, he founded Celiac.com with a clear mission: to ensure no one would have to navigate celiac disease alone. The site has since grown into one of the oldest and most trusted patient-focused resources for celiac disease and the gluten-free lifestyle.

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