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Can Someone Take A Look At My Test Results?

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Hey guys,


I've been trying to figure out what's wrong with my body. I'm 24 years old (male) and for the last couple years I have trouble healing certain injuries. If I fall and hurt my wrist, the pain won't go away with time. If I hit my knuckle on something, it's tender for the next 2 months, instead of healing the same week like it would with most people. I can list off a huge list of problems I have (shin splints, shoulder pain, back pain, headaches, I look tired all the time (bags under eyes) etc)


My doctor isn't very proactive, I had like 10 tests done before this one to check for deficiencies in vitamins and minerals and all I got was a 3 second message from my doctors office. I had to pick up the paperwork and try to figure it all out myself.


So I was hoping someone could look at my results for my "Celiac Disease Antibody Profie CELIAC" that I just received and tell me if I have anything to worry about related to allergies to gluten, or if you have any other ideas what might be wrong with me, I'd appreciate it.





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Welcome to the board.


The celiac screen your doctor used is an older one but a couple of those tests are still used by most doctors. The tTG IgA shows that damage is attempting to be inflicted on the gut but yours is negative. The problem is that your doctor did not test your total serum IgA which is a control test to make sure you make enough IgA for the IgA based tests to be accurate - 5% of celiacs are deficient in IgA. It is possible that you are low in IgA so I suggest getting that tested to make sure your tests are actually an accurate representation of what's going on. Right now it looks negative for celiac.


The EMA IgA test (titre) is positive only when advanced damage occurs in the intestine. It is very unusual for an EMA test to be positive if the tTG test is negative.


I know very little about the reticulin tests except that they are older and haven't been used much for about 10 years.


The anti-gliadin tests (AGA IgA and AGA IgG) are not used as much anymore either. They test for sensitivity to gliadin (gluten) and are thought by some to work for testing non-celiac gluten intolerance (NCGI) as well as celiac disease, the only problem is that the tests aren't the most sensitive or specific, meaning they don't catch all people with celiac disease or NCGI and when they are positive it is not always due to a gluten issue.


This report has more info on the tests on pages 10-12: http://www.worldgastroenterology.org/assets/export/userfiles/2012_Celiac%20Disease_long_FINAL.pdf


The only celiac disease tests they did not run were the deaminated gliadin peptides (DGP IgA and DGP IgG) and the tTG IgG. The DGP test is a new good one, and it seems to compliment the tTG tests by picking up many celiac disease cases that the tTG's do not. There is also the endoscopic biopsy; there are a few around here who had negtive blood tests but a positive biopsy - that could possibly apply to you too. If you decide to have those tests done, make sure you are still eating gluten or it will affect the results.


Right now, if I assume your total serum IgA is normal, it looks like you don't have celiac disease. It is possible you have NCGI for which there are no fully accepted blood tests yet, only a positive trial on the gluten-free diet is diagnostic. Those with NCGI will have all of the symptoms of celiac disease but no villi blunting.


How is your thyroid? Those with hypothyroidism have a slower metabolism as well as aches and pains. If you get it checked, your TSH should be near a 1 and your free T4 and free T3 should be in the 50-75% range of your lab's normal reference range.


Good luck with future testing or the gluten-free diet.

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