Iga Tissue Transglutaminase Results

[sharkylou]

Hi

I recently had a blood test to see if I have Celiac disease but I don't understand the results

<1 kU/L (0-5)

This is what is on my test papers

Any help would be great

Thanks

Louise

[nvsmom]

Welcome to the board.  

 

It looks like the normal reference range for that tTG IGA test is 0-5 and your result was less than 1 (<1).  It looks like that result was negative for celiac disease.

 

If you are concerned that you have celiac disease though, you should probably get more testing done.  The tTG IgA has a sensitivity that can be as low as 75%, which means it can miss up to a quarter of all celiacs.  If you can, try to get the full celiac panel run:

• ttG IgA and tTG IgG
• DGP IgA and DGP IgG (deaminated gliadin peptides)
• EMA IgA (endomysial antibodies)
• total serum IgA - a control test
• AGA IgA and AGA IgG (anti-gliadin antibodies) - older and less reliable tests largely replaced by the DGP tests
• endoscopic biopsy - ensure 6+ samples are taken

At the very least, have your total seum IgA (Immunoglobulin A) checked.  About 5% of celiacs are deficient in IgA which will cause false negative IgA based celiac disease tests (tTG IgA, DGP IgA, EMA IgA).  Get it checked to make sure this test is less likely to be giving you a false negative.

 

You were eating gluten in the weeks prior to testing right?  Eating gluten-free will eventually vcause negative blood tests for all celiacs.

 

Hope that helped a bit.  

[sharkylou]

Thanks that's great, I will ask my doctor for more tests

Louise