Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):
    GliadinX



    Celiac.com Sponsor (A1-M):
    GliadinX


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

DNA Testing


Jessi Leigh

Recommended Posts

Jessi Leigh Newbie

What exactly does a "low likelihood" dna test mean?  I've asked for a print out of the results, but my Dr hasn't responded.  I've heard mixed things- might be positive for one allele and not another?  I've exhibited all the symptoms for years, but my new doc did the dna test.  He's an RA, btw, and is not experienced with celiac.


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):
Authentic Foods
NutHouse! Granola Co.



Celiac.com Sponsor (A8-M):
Food for Life


Jmg Mentor

Obviously you need to pin that Doctor down and get a straight answer but I think genetics testing can only exclude, not diagnose:

  Quote

   Therefore, the celiac disease gene tests are mainly useful to rule out celiac disease in cases where Open Original Shared Link are present. 

Expand Quote  

Open Original Shared Link

So if it's low liklihood that sounds like it's not excluded celiac, just that you may not have the optimum pairings of genes for highest risk:

Open Original Shared Link

Even if the genetics tests excludes celiac you can still have gluten intolerance! 

Best of luck :)

GF-Cheetah Cub Contributor

I probably should leave your question to the experts, but I am going to answer it anyway...

My understanding is that there are two genetic markers that can cause celiac disease in a person.  They are DQ2 and DQ8.   If you are not a carrier of DQ2 or DQ8, you will not develop celiac disease.   If you do carry these genes, you still may not have celiac, but have the potential for it.

There are different DQ Genotypes that carry different degree of risks for developing celiac disease.

I am going to guess that you do carry the DQ2 or DQ8 gene, but one of the lower risk version known to develop into celiac disease.  

Since (or if you indeed) you carry the gene, I think you should schedule an endoscopy and to confirm or rule out the actual disease.

 

workingk9 Newbie
  On 6/18/2016 at 6:27 AM, GF-Cheetah Cub said:

I probably should leave your question to the experts, but I am going to answer it anyway...

My understanding is that there are two genetic markers that can cause celiac disease in a person.  They are DQ2 and DQ8.   If you are not a carrier of DQ2 or DQ8, you will not develop celiac disease.   If you do carry these genes, you still may not have celiac, but have the potential for it.

There are different DQ Genotypes that carry different degree of risks for developing celiac disease.

I am going to guess that you do carry the DQ2 or DQ8 gene, but one of the lower risk version known to develop into celiac disease.  

Since (or if you indeed) you carry the gene, I think you should schedule an endoscopy and to confirm or rule out the actual disease.

 

Expand Quote  

I am curious about this. My sister has biopsy confirmed celiac disease and my niece (not my sister with celiac's daughter, but a different sister's daughter) also has biopsy confirmed celiac disease. I am negative for rs7454108 (HLA-DQ8) and rs2187668 (HLA-DQA1), but I am homozygous for rs842647 (REL) and rs601338 (FUT2) and heterozygous for many ICOS genes and a couple other genes associated with celiac disease risk.  According to this article--  Open Original Shared Link

*Most* people with celiac disease will have HLA polymorphisms, *but* new studies are showing a correlation with polymorphisms in other genes and celiac disease.  Open Original Shared Link

I have an appt with a GI on June 27th to see if I have celiac disease or gluten sensitivity and to ask about the gene issues. 

I am new to the board. Am overwhelmed with the info. I don't want to hijack this thread so I will start a new one with regards to my symptoms and history. 

 

Carey

Jessi Leigh Newbie

I got the print out and took it to my new dr because what my RA was saying didn't seem to add up.  When I pressed him for more info, he said I didn't have any of the markers. Turns out he read the test wrong!  Since then, my new doc also questioned all my previous bloodwork and asked why I hadn't been told that my counts were really low or tested for ferritin levels. My ferritin was at 10, so, yeah, 4 other Dr's missed anemia on my labs. It's been frustrating to say the least, but I am finally feeling a little bit hopeful with my new primary doc. She's just referred me to a specialist focusing on celiac. Considering my former gp told me "that whole celiac thing is just a fad", I'm feeling a bit more secure. 

Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):
    Food for Life



  • Member Statistics

    • Total Members
      129,977
    • Most Online (within 30 mins)
      7,748

    Redrayvyn
    Newest Member
    Redrayvyn
    Joined

  • Celiac.com Sponsor (A20):
    NutHouse! Granola Co.


  • Forum Statistics

    • Total Topics
      121.3k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):
    GliadinX




  • Celiac.com Sponsor (A21):
    Authentic Foods



  • Upcoming Events

  • Posts

    • Scott Adams
      It sounds like your gastroenterologist is becoming increasingly confident that celiac disease is the likely diagnosis based on both your older and newer lab results. Her suggestion to call each Monday for possible cancellations is actually a great strategy—especially given how long the wait is until your August 29th appointment. It’s also a good sign that she’s advocating for you to be seen sooner, which shows she’s taking your case seriously. The fact that some labs might not have been drawn yet due to overlap with your functional health doctor’s upcoming testing adds a layer of confusion, but that’s unfortunately common when multiple providers are involved. Hopefully, the GI’s...
    • cristiana
      Thanks for sharing that film, @trents.  I am not sure how I missed that film as I see it is a few years old, but it is very good.  I think you should be fine if you take your own packed lunch and eat it from your own lunchbox etc.  Might be worth doing a lunchtime recce to see how cramped the room is before making a decision - for all you know, there may be other people  there who don't eat gluten?
    • cameo674
      The GI doc messaged me this afternoon that she believes that the new blood work added to the old is definitely  looking like a celiac diagnosis is in my future.  She wants to me to call into scheduling each Monday to see if I can get my August 29th appointment moved up due to cancellations.  I have never had a doctor recommend that.  She also said there were additional labs that she requested still out that have not come back yet; so, they may have been missed drawing those since the functional health doctor has a whole slew of labs that I am suppose to be waiting until August 27th to do. I am still waiting to hear on whether or not she will allow me to do pill prep versus the typical...
    • Alibu
      Well, I've made if from the pre-diagnosis forum to here!  I've been diagnosed with "latent" or "potential" celiac and my doctor has suggested me to go gluten-free before my appointment with him in October (first available, LOL).  My ttg-iga was 152, my EMA was positive, I have the gene, but my biopsy was negative (and he took 12 samples), so it makes sense to go gluten free to see if I improve. I know the basics - I can find lists of things to avoid, I know about hidden dangers, etc. all of that.  Where I'm struggling is just STARTING.  I need to go shopping and stock up on some staples.  My goal is to not try to find gluten-free alternatives, but to focus on naturally gluten-free foods like...
    • Scott Adams
      It’s great that you were finally able to see a gastroenterologist—and even luckier to get in the same day as your referral! It sounds like your GI is taking a very thorough approach, which is reassuring given your complex symptoms and history. The confusion around your different tissue transglutaminase (tTG) antibody results is understandable. The variation between your December and June labs may be due to multiple factors, including differences in the lab performing the test (Quest vs. Mayo Clinic), the specific assay used, and the amount of gluten you had been consuming before each test. Antibody levels can drop significantly when gluten is reduced or eliminated from the...
×
×
  • Create New...