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Help on blood test results

JeromeP

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JeromeP Newbie
JeromeP
Posted

Hello everyone,

 

I have been reading the forums quite a bit lately and wanted to take the time and thank the community for the support you provide. I am sure lots of us don't post but get reassured from reading...

I have had health problem for about 10 years now, but it really started to be bad for the past 4 years. After MANY tests and exams, I finally asked my doctor to test me for Celiac as my previous doctor didn't bother looking into that.

I would truly appreciate if someone could help me decipher the results I just received, as my doctor referred me to a GI saying it was not his expertise and didn't want to give me false diagnosis. Unfortunately, my appointment is in more than a month away, I don't really want to wait..

Celiac Disease Comprehensive

  • t-Transglutaminase (tTG) IgG, <2 (negative)
  • t-Transglutaminase (tTG) IgA, <2 (negative)
  • Endomysial Antibody IgA, Negative
  • Immunoglobulin A, Quant, Serum, 530 mg/dL (high)
  • Deamidated Gliadin Abs, IgA, 13 (negative)
  • Deamidated Gliadin Abs, IgG, 62, (>30 strong positive)

After (too) much reading, it appears that a positive Deamidated Gliadin Antibody IgG shows gluten immune reactivity but because of the other test (especially the tTG IgA and EMA) being negative, it does not indicate Celiac. My conclusion is I have a high probability to have non-celiac gluten sensitivity.

I'm seeing the GI next month and will be able to gain more understanding, but if anyone has knowledge on these tests, I would truly appreciate help.

Thank you

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GFinDC Veteran
GFinDC
Posted

Hi Jerome,

 

The DGP IgG being positive is very specific for a celiac disease indicator.  there only needs to be one positive antibody for celiac to be present.  The 2nd part of diagnosis is usually an endoscopy to check for villi damage.

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      Is this celiac?

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      - trents replied to kpf's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
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      ttg iga high (646 mg/dl) other results are normal

      knitty kitty asks a very relevant question. So many people make the mistake of experimenting with the gluten free diet or even a reduced gluten diet soon before getting formally tested.
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    • knitty kitty
      Is this celiac?

      By knitty kitty · Posted

      @Hmart, The reason why your intestinal damage was so severe, yet your tTg IgA was so minimal can be due to cutting back on gluten (and food in general) due to worsening symptoms.  The tTg IgA antibodies are made in the intestines.  While three grams of gluten per day for several weeks are enough to cause gastrointestinal symptoms, ten grams of gluten per day for for several weeks are required to provoke sufficient antibody production so that the antibodies move out of the intestines and into the blood stream where they can be measured in blood tests.  Since you reduced your gluten consumption before testing, the antibody production went down and did not leave the intestines, hence lower than expected tTg IgA.   Still having abdominal pain and other symptoms this far out is indicative of nutritional deficiencies.  With such a severely damaged small intestine, you are not absorbing sufficient nutrients, especially Thiamine Vitamin B 1, so your body us burning stored fat and even breaking down muscle to fuel your body.   Yes, it is a very good idea to supplement with vitamins and minerals during healing.  The eight essential B vitamins are water soluble and easily lost with diarrhea.  The B vitamins all work together interconnectedly, and should be supplemented together.  Taking vitamin supplements provides your body with greater opportunity to absorb them.  Thiamine and the other B vitamins cannot be stored for long, so they must be replenished every day.  Thiamine tends to become depleted first which leads to Gastrointestinal Beriberi, a condition that doctors frequently fail to recognize.  Symptoms of Gastrointestinal Beriberi are abdominal pain and nausea, but neuropathy can also occur, as well as body and joint pain, headaches and more.  Heart rhythm disruptions including tachycardia are classic symptoms of thiamine deficiency.  Heart attack patients are routinely administered thiamine now.   Blood tests for vitamins are notoriously inaccurate.  You can have "normal" blood levels, while tissues and organs are depleted.  Such is the case with Gastrointestinal Beriberi, a thiamine deficiency in the digestive tract.  Eating a diet high in carbohydrates, like rice, starches, and sugar, can further deplete thiamine.  The more carbohydrates one eats, the more thiamine is required per calorie to turn carbs into energy.  Burning stored fats require less thiamine, so in times of thiamine shortage, the body burns fat and muscles instead.  Muscle wasting is a classic symptoms of thiamine deficiency.  A high carbohydrate diet may also promote SIBO and/or Candida infection which can also add to symptoms.  Thiamine is required to keep SIBO and Candida in check.   Thiamine works with Pyridoxine B 6, so if Thiamine is low and can't interact with Pyridoxine, the unused B 6 accumulates and shows up as high.   Look into the Autoimmune Protocol diet.  Dr. Sarah Ballantyne is a Celiac herself.  Her book "The Paleo Approach" has been most helpful to me.  Following the AIP diet made a huge improvement in my symptoms.  Between the AIP diet and correcting nutritional deficiencies, I felt much better after a long struggle with not feeling well.   Do talk to your doctor about Gastrointestinal Beriberi.  Share the article linked below. Thiamine, gastrointestinal beriberi and acetylcholine signaling https://pmc.ncbi.nlm.nih.gov/articles/PMC12014454/ Keep us posted on your progress!
    • Trish G
      Fiber Supplement

      By Trish G · Posted

      Thanks, that's a great addition that I hadn't thought of. 
    • trents
      Is this celiac?

      By trents · Posted

      Other diseases, medical conditions, medications and even (for some people) some non-gluten foods can cause villous atrophy. There is also something called refractory celiac disease but it is pretty uncommon.
    • trents
      ttg iga high (646 mg/dl) other results are normal

      By trents · Posted

      knitty kitty asks a very relevant question. So many people make the mistake of experimenting with the gluten free diet or even a reduced gluten diet soon before getting formally tested.
    • trents
      Fiber Supplement

      By trents · Posted

      Another great fiber option is dried apricots. Four of them give you 3g of fiber and I find they don't produce all the gas that some other high fiber options do. They taste good too. Costco sells a large bag of them that are labeled gluten-free so you don't have to worry about cross contamination issues like you might in bulk grocery settings.
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