Jump to content
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.


  • Celiac.com Sponsor (A1):
    Celiac.com Sponsor (A1-M):
  • Join Our eNewsletter:
    Support Our Content
    eNewsletter
    Donate

Celiac Disease Help


JacobDO77

Recommended Posts

JacobDO77 Newbie

Celiac disease is a disorder, resulting from an immune response to Gluten, it is an autoimmune disease.  Gluten is comprised of two Proteins and Carbohydrates.  The two proteins are Glutelin (Glutenin) and Gliadin.  Gluten is found in wheat, rye, barley, oats and many other foods.

The protein Gliadin is responsible for many food derived pathogens and inflammatory responses that cause illness and abnormal conditions.  In a normal health body, the proteins in Gluten are destroyed, in the stomach, by the action of strong Hydrochloric acid and the Peptic enzymes. When the Peptic enzymes are not active, in the conversion of proteins, because of weak Hydrochloric acid, the allergenic proteins are dumped into the small bowel.  This premature dumping, of raw nutrients into the small bowel, results in an autoimmune response.

Gliadin in the Gluten, causes the activation of Zonulin, a small protein molecule, produced in the body. Zonulin, when activated, opens up the intracellular spaces, between the cells, of the intestines. The more Zonulin molecules are activated, the larger the spaces between the cells, will be. Increasing the intracellular spaces, will allow larger molecules, of nutrients, to pass through the intestinal lining, into the blood stream.

Gliadin and the activation of Zonulin will lead to sever diseases, of the intestinal tract mucosa, in adults and children. Gluten sensitivity appears in 1 of every 300 births.  In children the incidence of Celiac disease is calculated at 90 to 100%.  In adults the disease is calculated at 75 to 90%. Autoimmune response, from Gliadin and Zonulin, in children causes failure to thrive, defects in tooth enamel, lack of proper growth, and a host of other symptoms.  One important indicator, of the onset of Celiac disease in children and adults, is dermatitis herpetiformis (skin rash).

The toxic effect of Gliadin and Zonulin, in the intestinal tract, will lead to intestinal lesions and inflammation. This can cause inflammatory bowel disease, ulcerative colitis, and Cronin's disease, Intestinal Barrier Impairment.

Celiac disease is the result of malabsorption, caused by Hypochlorhydria and Achlorhydria.  Both conditions, stop the eradication of the protein allergens, in Gluten, by eliminating the Peptic enzymes, in the protein conversion process.

The symptoms associated with Hypochlorhydria related celiac disease are, diarrhea and/or constipation, vitamin and mineral deficiency, anemia, abdominal pain, nausea, gas, belching, bloating, osteoporosis, fatigue, flatulence, dermatitis, Intestinal Barrier Impairment, etc.

Hypochlorhydria and Achlorhydria are caused by aging, the use of antibiotics, antihistamines, steroids, Proton Pump Inhibitors (PPIs), excessive use of antacids, alcohol, etc. Both conditions will allow unsterilized and unconverted proteins and nutrients to dump into the small bowel, resulting in an autoimmune response. The symptoms associated with Hypochlorhydria and Achlorhydria are: malabsorption of vitamin B-12, K, D, reduced absorption of calcium, iron, magnesium, and other minerals. 

There is a lot more info on the various testing procedures for Celiac disease, search the net for pH gastrogram, pH diagnostic test and pH capsule test.


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



kareng Grand Master
1 hour ago, JacobDO77 said:

Celiac disease is a disorder, resulting from an immune response to Gluten, it is an autoimmune disease.  Gluten is comprised of two Proteins and Carbohydrates.  The two proteins are Glutelin (Glutenin) and Gliadin.  Gluten is found in wheat, rye, barley, oats and many other foods.

The protein Gliadin is responsible for many food derived pathogens and inflammatory responses that cause illness and abnormal conditions.  In a normal health body, the proteins in Gluten are destroyed, in the stomach, by the action of strong Hydrochloric acid and the Peptic enzymes. When the Peptic enzymes are not active, in the conversion of proteins, because of weak Hydrochloric acid, the allergenic proteins are dumped into the small bowel.  This premature dumping, of raw nutrients into the small bowel, results in an autoimmune response.

Gliadin in the Gluten, causes the activation of Zonulin, a small protein molecule, produced in the body. Zonulin, when activated, opens up the intracellular spaces, between the cells, of the intestines. The more Zonulin molecules are activated, the larger the spaces between the cells, will be. Increasing the intracellular spaces, will allow larger molecules, of nutrients, to pass through the intestinal lining, into the blood stream.

Gliadin and the activation of Zonulin will lead to sever diseases, of the intestinal tract mucosa, in adults and children. Gluten sensitivity appears in 1 of every 300 births.  In children the incidence of Celiac disease is calculated at 90 to 100%.  In adults the disease is calculated at 75 to 90%. Autoimmune response, from Gliadin and Zonulin, in children causes failure to thrive, defects in tooth enamel, lack of proper growth, and a host of other symptoms.  One important indicator, of the onset of Celiac disease in children and adults, is dermatitis herpetiformis (skin rash).

The toxic effect of Gliadin and Zonulin, in the intestinal tract, will lead to intestinal lesions and inflammation. This can cause inflammatory bowel disease, ulcerative colitis, and Cronin's disease, Intestinal Barrier Impairment.

Celiac disease is the result of malabsorption, caused by Hypochlorhydria and Achlorhydria.  Both conditions, stop the eradication of the protein allergens, in Gluten, by eliminating the Peptic enzymes, in the protein conversion process.

The symptoms associated with Hypochlorhydria related celiac disease are, diarrhea and/or constipation, vitamin and mineral deficiency, anemia, abdominal pain, nausea, gas, belching, bloating, osteoporosis, fatigue, flatulence, dermatitis, Intestinal Barrier Impairment, etc.

Hypochlorhydria and Achlorhydria are caused by aging, the use of antibiotics, antihistamines, steroids, Proton Pump Inhibitors (PPIs), excessive use of antacids, alcohol, etc. Both conditions will allow unsterilized and unconverted proteins and nutrients to dump into the small bowel, resulting in an autoimmune response. The symptoms associated with Hypochlorhydria and Achlorhydria are: malabsorption of vitamin B-12, K, D, reduced absorption of calcium, iron, magnesium, and other minerals. 

There is a lot more info on the various testing procedures for Celiac disease, search the net for pH gastrogram, pH diagnostic test and pH capsule test.

Did you have a question? Or did you mean this to be a response to another poster?

kareng Grand Master

As you are copying this text from another source, you should reference the source.  

Archived

This topic is now archived and is closed to further replies.

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate

  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Recent Activity

    1. - Aretaeus Cappadocia replied to Irishgirl5's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Digestive symptoms yet negative celiac screening

    2. - Scott Adams replied to Russ H's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      1

      Fiber-Metabolizing Bacteria Could Boost Gut Health in Celiac Disease

    3. - Scott Adams replied to Irishgirl5's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Digestive symptoms yet negative celiac screening

    4. - Scott Adams replied to Stegosaurus's topic in Super Sensitive People
      2

      trehalose intolerance

  • Celiac.com Sponsor (A19):
  • Member Statistics

    • Total Members
      133,995
    • Most Online (within 30 mins)
      10,442

    Jody Booker
    Newest Member
    Jody Booker
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):
  • Forum Statistics

    • Total Topics
      121.6k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):
  • Upcoming Events

  • Posts

    • Aretaeus Cappadocia
      You may know this already, but in addition to what you've described, you may also want to get a genetic test. About 1/3 of people have one of the genetic markers that are necessary (but not sufficient) for getting celiac. If your son is one of the 2/3 of people that don't have the marker then it is almost certain he does not have celiac. (The genetic test won't tell you if he has celiac, it can only tell you whether or not he is susceptible to getting celiac.)
    • JennMitchell79
    • Scott Adams
      That is really interesting, especially because it points to how the gut microbiome may still stay altered in celiac disease even after going gluten-free. The idea that a fiber like inulin could help feed beneficial bacteria and reduce inflammation is encouraging, although I imagine some people with celiac disease or other gut issues might still need to introduce it carefully depending on tolerance. It definitely feels like an area worth watching, because anything that could help support healing beyond just avoiding gluten would be valuable.
    • Scott Adams
      @Irishgirl5, it does sound possible for those numbers to fluctuate a bit, especially when they are near the upper end of normal, but ongoing symptoms still make it understandable that you are concerned. The fact that his tissue transglutaminase immunoglobulin A is still technically in range does not always make the picture feel any clearer, especially with tummy pain, nausea, constipation, and diarrhea still going on. Anxiety can certainly add to gastrointestinal symptoms, but I can see why you would not want to assume that explains everything. It sounds like keeping an eye on things and being cautious with diet changes makes sense, especially if symptoms continue. Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.
    • Scott Adams
      @Stegosaurus, that is really interesting, and it sounds like you have done a lot of careful digging into what might be driving your symptoms. The connection between dysbiosis, food reactions, and specific additives or sugars is clearly complicated, but your point about hidden ingredients and individual tolerance makes a lot of sense. It is also encouraging that you found something, like the fermented Florastor approach, that seems to help you tolerate certain foods better. Posts like this are helpful because they remind people that sometimes the reaction is not just about the obvious ingredient on the label.
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.