L-Glutamate supplement

[Denise Bu]

I've been hearing that L-glutamine is helpful for healing leaky gut but I can't find specific scientific literature explaining how it works. The journal abstracts that mention L-glutamine in passing discuss enzymes like TG2 (transglutaminase) and their role in converting peptides. It is really confusing to understand what they are saying.  Can anyone point me to some good research that is clearly about this and explains how the body uses L-glutamine to heal the gut?   

[ch88]

L-glutamine is the primary food source for the cells that line the gut. The cells in the gut act differently when they have lots of food.  Leaky gut is linked to inflammation and stress in the gut.  In the link below, there is a diagram which shows how glutamine supplementation can lead to improved control over tight junctions within the gut. The idea is that L-glutamine supplementation increases the production of other proteins that help protect against leaky gut syndrome. 

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