DGP IGA 38.9

[Mashpo1]

Hi all.

 

Below are my blood test results (from November 2020, whilst still eating gluten)

ANTI DGP IGA MULTIPLEX 38.90 U/ML !( 0.00- 15.00) POSITIVE 

 

ANTI TTG IGA MULTIPLEX NEGATIVE
<0.5 U/ML ( 0.00- 15.00)

ANTIENDOMYSIAL IGA NEGATIVE

CALPROTECTIN 2940.00 UG/G

My symptoms: 

since November last years I had abdominal distension/bloating/gas/ joint pain/diarrhea and constipation/nausea/ weight loss/insomnia. I'm having a breath test to check for SIBO next monday.

In the first  months I also had  neurologic  symptoms: weakness, fainting every now and then, peripheral neuropathy(loss of feeling in my hands), tremors, night sweats, etc. Now all those symptoms are  mainly gone but sibo symptoms still persist.

Biopsy results ( March 2021) turned negative. But I was on a  gluten free diet.

 I do not intend to do any "gluten challenge" soon and to damage my health any further  since  my symptoms worsened after gluten ingestion.

I have been to four GI specialists to receive a celiac diagnosis .

 

None of them was eager to give the diagnosis despite the high anti DGP IGA levels.  

 

If I want a celiac diagnosis, they say,  I need to eat gluten for six weeks before the test.

 

I do not understand - Why on earth do they keep on insisting I should do the gluten challenge and wreaking havoc on my health despite evidence from the positive  blood tests result and clinical symptoms ?

I feel something is wrong with the "gold standard" test and modern medicine. What do you think?

 Pardon my English errors. I am a non native speaker.

 

[trents]

" Anti-DGP Screen detects antibodies of both subclasses, IgA and IgG in a single test step, and thus also identifies celiac disease patients with IgA deficiency." https://www.orgentec.com/en/products/alegria/Autoimmune+Disease+Diagnostics/Gastroenterology+Diagnostics/Anti-DGP.html

 

The TTG IGA test is considered to be the primary antibody test for celiac disease and in your case it was negative. I am guessing that is why your physicians are hesitating to give you a celiac diagnosis without more testing. However, even if someone does have celiac disease and currently still eating gluten the TTG IGA can be negative if the total IGA level is low. In your case, you have a more general, less specific antibody test (anti DGP multiplex) for celiac disease that is quite positive.

If your symptoms have definitely improved after going gluten free it seems to me you have the evidence you need. 

[Scott Adams]

Yes I agree, it sounds to me like you’ve already figured out that you are at least gluten sensitive with possible celiac disease. There is no test yet for gluten sensitivity, so even if you did do a gluten challenge and get re-tested, it may not give you a definitive answer.