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Help interpreting blood test results


Mamaof21985

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Mamaof21985 Newbie

I’ve been having stomach issues for years and just kept it to myself and dealt with it. I finally went to the dr a week and a half ago and he suggested we test for celiac. He was conflicted between celiac and Crohn’s disease. We did bloodwork that morning.  After my appointment I went home and started a gluten free diet just to see what would happen. After about 3 days I was feeling quite a difference. My stomach bloating was even mostly gone. Then 5 days into this, we went to a family members birthday party where they had pizza. I wasn’t going to eat it but I thought it would also be a good test so I ate the pizza. By that evening I was miserable and the next day my stomach looked like I was 6 months pregnant. It has now been 3 days since then and I am just now starting to feel a little better since not having anymore gluten. 
Yesterday, my dr emailed me saying one of my blood tests came back elevated and that he wants to refer me to a gastro dr to possibly do a colonoscopy. I emailed him back asking that he send me a copy of the labs. I also decided to hold off for now on the other dr. I want to try completely gluten free for a month and see how much improvement I actually have and if I’m still having problems then I will go to the other dr. 
I have learned through researching that to continue testing you have to be consuming gluten so I am aware of that but at this point if gluten makes me feel this horrible then I would just rather not have it. 
I am a little confused by my blood test results though so maybe someone here can help me understand?

Atypical pANCA - negative

Saccharomyces cerevisiae, IgG 76.6

     (Range 0.0-24.9)

tTG/DGP Screen - negative 


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trents Grand Master

Your doctor failed to order the most important antibody test for celiac disease, the tTG-IGA which is the centerpiece of the celiac antibody panel: https://celiac.org/about-celiac-disease/screening-and-diagnosis/screening/

You should be on regular amounts of gluten (defined as daily consumption of gluten in the equivalent of two slices of wheat bread) for 6-8 weeks preceding the antibody testing and for at least two weeks prior to the endoscopy/biopsy. Those are Mayo's guidelines. By goin gluten free before testing you risk invalidating the tests and injecting uncertainty into the diagnosis.

Scott Adams Grand Master

Welcome to the forum. I agree that your doctor should have ordered the tTG-IGA test. If your goal is to get a formal diagnosis that would help you stay gluten-free for life, then yes, you should keep eating gluten daily until all tests are done. However, ~10x more people have non-celiac gluten sensitivity than celiac disease, and for that there is currently no test available. To me it sounds, at the very least, like you have NCGS, and would likely need to go gluten-free either way, but this is for you to decide. If your symptoms are that bad, and go away when you exclude gluten, do you need any further confirmation?

RMJ Mentor
7 hours ago, Mamaof21985 said:

Atypical pANCA - negative

Saccharomyces cerevisiae, IgG 76.6

     (Range 0.0-24.9)

tTG/DGP Screen - negative 

It is difficult to tell exactly which celiac tests were done.  tTG/DGP does include both types of tests, but it doesn’t say whether it was IgA or IgG and doesn’t give numbers so one can’t tell if it is very negative or just under the cutoff for positive.

Saccharomyces is a type of yeast, and having antibodies to it as you do is a possible indicator of inflammatory bowel disease, thus the recommendation for a colonoscopy. (For celiac disease doctors do an endoscopy not a colonoscopy).

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