"Did you/or do you KNOW?"

[Yvonne (Vonnie) Mostat, RN]

Latest study  published in JAMA, researchers screened 4,24,788 newborn infants for HLA (A genetic predisposition to the development of celiac disease),  Of these, 6, 757 participated,, representing 1.44% of the study population.  The results of this study indicated each additional gram of gluten consumption per day was associated with a 50% increased risk of celiac disease in genetically predisposed children at age 3.  However, because the results were based on such a small subset of the larger sample, the results may not be representative of the broader population.

The second study published in the American Journal of Gastroenterology, examined data collected from 1,875 at-risk children between 1993 and 2017. Of th4ese, 151 (8.5%) developed celiac disease autoimmunity (positive blood antibodies) and 85 (4.5% developed celiac disease (biopsy-verified or persistently high blood antibodies).  The researchers found the risk of celiac disease autoimmunity increased by 5% for each gram of gluten consumed between the ages of 1 and 2 years of age.  The risk of later developing celiac disease autoimmunity was found to be strongest for an increased gluten intake at 1 year of age. However, these results were also based on a small subset (3.3%) of the larger sample, focusing only on genetically at-risk children. Because of this, these results should not be generalized to recommendations for children irrespective of genetic risk.

 

Lastly, The AMerican Journal of Gastroenterology recently published a study examinining tyhe moBa-cohort. Unlike the previous two studies, this sstudy was population based and did not consider genetic risk  (HLA)O.  Of ccourse some 113,000 children initially enrolled.  67,608 were included in the study, 738 (1.1%) of whom were diagnosed with celiac disease. The rsearchers found that risk of celiac disease inceased by 3% with each gram of extra gluten intake per day, with gluten who were introducd to gluten at 6 months of age or older havng a significantly higher risk of celiac disease than those introduced at 4 - 6 months.

While the rsults of these three studies suggest that one extra clice of bread (about 2 grams of gluten) per daY SEEMS TO BE LINKED TO AN 20 - 

[trents]

Vonnie, the way this was presented was confusing to me.

"screened 4,24,788 newborn infants" There's a digit missing there somewhere between the first and second commas I believe.

"HLA" One or both genes that have been identified with celiac disease potential?

"While the rsults of these three studies suggest that one extra clice of bread (about 2 grams of gluten) per daY SEEMS TO BE LINKED TO AN 20 -" This is your last line. Looks like an incomplete thought or sentence.

Is there a summary conclusion that will tie together the findings of all three studies? Something like, if your infant has one or both celic potential genes, feeding them gluten before the age of xx increases the likelihood they will develop active celiac disease by xx%? I'm not sure what the application is here from the data.

You might want to go back and reread your post to correct typos.

Edited May 12, 2022 by trents