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Confused - Genetic Codes

MicheleBrand
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Scott Adams Grand Master
Scott Adams
Posted

I just wanted to post this update which came to be via email directly from Dr. Kenneth Fine--he doesn't have time to join the forum and reply to questions directly, but here is his reply to some of the posts here about his lab and methods:

So, Dr. Fine believes that gluten sensitivity (NCGS) is or can be preliminary to celiac disease, that it is not a distinct condition. Correct?:

Quote

NCGS may precede Celiac Disease, OR be a distinct syndrome.  The genetics are foremost important; the triggers and environmental factors that turn the 42% of the public with celiac genes into the ~1% with true celiac are second but still important.

Since the celiac "tip of the iceberg" is really clinically and epidemiologically minor compared with the millions of people with NCGS, I have started using the phrase "celiac equivalent" which has been showing to be much much more common: Gene positive for DQ2 and/or DQ8; positive fecal antibodies to gliadin; positive test for malabsorption.

And I have broken with the circa 1950's/1960s "gold standard"... must have a biopsy to qualify for needing or benefiting from a gluten free diet about 1 hour into my stint with EnteroLab...that is, April 2000!

 

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trents Grand Master
trents
Posted
3 hours ago, Scott Adams said:

I just wanted to post this update which came to be via email directly from Dr. Kenneth Fine--he doesn't have time to join the forum and reply to questions directly, but here is his reply to some of the posts here about his lab and methods:

So, Dr. Fine believes that gluten sensitivity (NCGS) is or can be preliminary to celiac disease, that it is not a distinct condition. Correct?:

 

So that prompts the question in my mind if Dr. Fine would say NCGS is an autoimmune disease like celiac but one that attacks some other body system. Yes? No? Sometimes?

knitty kitty Grand Master
knitty kitty
Posted
20 minutes ago, trents said:

So that prompts the question in my mind if Dr. Fine would say NCGS is an autoimmune disease like celiac but one that attacks some other body system. Yes? No? Sometimes?

It's been found that people with Gluten Ataxia have antibodies called Ttg 6. 

Celiac people who have Gluten Ataxia also make high levels of  antibody Ttg 6 as well as high levels of Ttg 2.

People with Non Celiac Gluten Sensitivity who have Gluten Ataxia also have high levels of tTg 6, but not tTg 2.

Ttg 6 antibodies cross the blood brain barrier and affect the brain and are involved in peripheral neuropathy as well. 

Ttg 6 antibodies are also found in neurodegenerative diseases like MS and Alzheimer's disease.

The scientists don't have it all figured out, but there's a connection.

Google this..... ncgs ttg6 nih

And you will get a ton of studies like this...

Neurological manifestation of coeliac disease with particular emphasis on gluten ataxia and immunological injury: a review article

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035534/

And...

Dietary Gluten and Neurodegeneration: A Case for Preclinical Studies

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432597/

 

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