H Pylori treatment while newly diagnosed

[GfreeOH]

Hello again!

I have tried to search the site thoroughly, but haven’t quite found the answers to the dilemma I’m having. Maybe someone else can offer some insight?

I recently had a positive EGD On 1/16/23. The EGD showed Villous flattening in the duodenum, and HPylori in the antrum something or the other. I has a positive h pylori test last year, and was only able to make it through 5 of the 10 days of the Pylera treatment. If I remember, it was 14 pills a day, and made my stomach so distended I just couldn’t handle it anymore. I stopped treatment after 5 days but stool test revealed it was negative for H Pylori after that. My EGD has revealed it again, and I’m taking another round of antibiotics. They prescribed Pantaparozole, Clarithomycin, and Metronidazole since I can’t have Penicillin due to anaphylaxis as a child.

I know the treatment is rough, but I’m only 3 days into a gluten free diet to heal vili damage, and these meds are giving me trapped gas (sharp pain under right rib), and again the severe distended abdomen. I called the pharmacy and they said all 3 do not contain gluten, but the Pantaparozole contains lactose  I’m severely lactose intolerant and Lactaid doesn’t help. I read the lactose they use in medication is different so I really don’t know if that is my issue, if the H Pylori is trying to die off and causing major gas and dissension, or if this is just par for the course. I look 6 months pregnant, or at least feel that way:(

Has anyone here with Celiac who already had pretty bad abdominal pain, made it through the full 10 day HPylori treatment successfully? Any tips? 

 

[RMJ]

1 hour ago, GfreeOH said:

I read the lactose they use in medication is different so I really don’t know if that is my issue
 

I don’t think the lactose would be different enough to eliminate lactose intolerance problems.  There are different physical options (for example, how fine the powder is) and it is available with or without a water molecule attached to the lactose molecule.

There are some pantaparazole formulations without lactose, or perhaps your doctor could prescribe a different proton pump inhibitor.

[GfreeOH]

2 minutes ago, RMJ said:

I don’t think the lactose would be different enough to eliminate lactose intolerance problems.  There are different physical options (for example, how fine the powder is) and it is available with or without a water molecule attached to the lactose molecule.

There are some pantaparazole formulations without lactose, or perhaps your doctor could prescribe a different proton pump inhibitor.

Thanks. I will call the GI office tomorrow and ask if they have a recommendation on a lactose free version. While the pharmacist was very helpful, she was also very busy and it took her 15 minutes to even look at the 3 meds they prescribed to find the active/inactive ingredients for me. I felt bad to make her go on a goose chase to try to find me a lactose free labeler of the Protonix, so thanked her and figured I would search on my own.

I googled it prior to posting but failed to find a lactose free labeler/manufacturer. The generic they provided was from Camber Pharmaceuticals, and it unfortunately had lactose. I thought maybe the two pills a day of filler lactose would be Ok. 

[Scott Adams]

You may be able to find a lactose free version of your med here, by searching for it, then viewing its inactive ingredients:

https://dailymed.nlm.nih.gov/dailymed/

I also had H. Pylori at the time of my diagnosis, but don't recall having issues with the meds at the time. Hopefully you can get through this period. Probiotics may be helpful.

[GfreeOH]

Thank-you, I will look into this. The course of meds has been very rough for me, unfortunately. I called the GI office yesterday after being up the evening prior until 3:30 AM with so much tummy distress (I get up for work at 6:30 AM). I assume it was from the Lactose in the Protonix but can't be certain as it doesn't affect "most" people that way. I just don't feel like "most" people with the host of food intolerances I have other than Gluten. I am certain my intolerances stem from years of malabsorption/Leaky Gut, but I am just in the beginning of healing at 45 years old.

When I called the GI office and got the nurse for my GI doc and asked her about the lactose in the generic Protonix I received, she said "hmm...I wouldn't have a clue" - acting as if I was totally out of my mind and she had never heard of such a thing. I broke down at that point in tears and informed her "I am sorry, but this practice is who prescribed me the course of treatment I am on. I am calling with a reaction from that treatment, and would expect that the professionals who have prescribed the treatment would help mitigate a solution for me. It is very frustrating that instead of my care provider recommending different options to me over the course of the last few years, I have had to do my own research and request for this practice to run different tests or consider other options ." She stated it could just be the antibiotics doing their work, but, I had to remind them that they stated for me NOT to take probiotics, and that that GI who did my EGD doesn't usually recommend it with the treatment. With that being said, I had to call the office again today to ask that she prescribe Diflucan to treat the yeast issue I am now having from the antibiotics ( yay for being a Woman).

From what I have read in doing my own research about the probiotics - I SHOULD be taking them with the course of harsh antibiotics to replace the good bacteria that the antibiotics are currently destroying. Due to the Leaky Gut, and my totally limited diet all these years (I don't do dairy, fermented foods, yogurt, or any of the probiotic rich foods I saw listed online) I would have to imagine that I didn't have alot of "good bacteria to counteract the antibiotics to start with. I bought some dairy-free Coconut yogurt to try, but saw Locust Bean as an ingredient and it's just too close to Pea Protein for me to give that a shot. I also bought some "Karma" water to try to see if that may be beneficial as it seems to be a non-dairy probiotic option that lacks some of the other things I'm more sensitive to. I also looked at a box of "Align" probiotics that I bought within the last 6 months, but it contains or is grown off Milk:(

It's been a journey, but I am sure once I'm on the other end of the treatment for HPylori, and the Villi heal from the Celiac, I will feel much better! 

 

[Scott Adams]

If you do a search for that drug here:

https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Protonix

you will see many results. You need to know the manufacturer of yours to know which to look at. For example, if I look at the first one there:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=08098cb2-c048-4640-f387-6beec4a38936

and see the Ingredients & Appearance area, I see the following, and don't believe any contain lactose or dairy, but that isn't my expertise...but don't ask your doctor what's in the inactive ingredients of your meds because they just won't know: 

Quote

CALCIUM STEARATE (UNII: 776XM7047L) 

CROSPOVIDONE (120 .MU.M) (UNII: 68401960MK) 

MANNITOL (UNII: 3OWL53L36A) 

FERRIC OXIDE YELLOW (UNII: EX438O2MRT) 

METHACRYLIC ACID AND ETHYL ACRYLATE COPOLYMER (UNII: NX76LV5T8J) 

POLYSORBATE 80 (UNII: 6OZP39ZG8H) 

POVIDONE K25 (UNII: K0KQV10C35) 

POVIDONE K90 (UNII: RDH86HJV5Z) 

PROPYLENE GLYCOL (UNII: 6DC9Q167V3) 

SODIUM CARBONATE (UNII: 45P3261C7T) 

SODIUM LAURYL SULFATE (UNII: 368GB5141J) 

TITANIUM DIOXIDE (UNII: 15FIX9V2JP) 

TRIETHYL CITRATE (UNII: 8Z96QXD6UM) 

HYPROMELLOSE 2910 (6 MPA.S) (UNII: 0WZ8WG20P6)

 

[GfreeOH]

15 hours ago, Scott Adams said:

If you do a search for that drug here:

https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Protonix

you will see many results. You need to know the manufacturer of yours to know which to look at. For example, if I look at the first one there:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=08098cb2-c048-4640-f387-6beec4a38936

and see the Ingredients & Appearance area, I see the following, and don't believe any contain lactose or dairy, but that isn't my expertise...but don't ask your doctor what's in the inactive ingredients of your meds because they just won't know: 

 

Thank you. I did check the labeler and found that the generic of Protonix I was prescribed had lactose. The pharmacy had recommended I have the GI call in another prescription for a lactose free PPI. When I called, that is when they said " I wouldn't have a clue", so I just felt defeated and like I was getting the run around. I did research myself and found a Rite Aid version of Omeperazole and switched myself to that today to see if that helps. 

[GfreeOH]

15 hours ago, Scott Adams said:

If you do a search for that drug here:

https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Protonix

you will see many results. You need to know the manufacturer of yours to know which to look at. For example, if I look at the first one there:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=08098cb2-c048-4640-f387-6beec4a38936

and see the Ingredients & Appearance area, I see the following, and don't believe any contain lactose or dairy, but that isn't my expertise...but don't ask your doctor what's in the inactive ingredients of your meds because they just won't know: 

 

Hi Scott!

Can you tell me if any of these are gluten ingredients? It is from Rite Aid Omeprazole:

benzyl alcohol, carmine, carnauba wax, FD&C blue #2/indigo carmine aluminum lake, flavor, hypromellose, hypromellose acetate succinate, lactose monohydrate, menthol, modified starch, monoethanolamine, polyethylene glycol 3350, sodium lauryl sulfate, sodium starch glycolate, sodium stearate, sodium stearyl fumarate, sucralose, talc, titanium dioxide, triacetin, triethyl citrate

[GfreeOH]

3 minutes ago, GfreeOH said:

Hi Scott!

Can you tell me if any of these are gluten ingredients? It is from Rite Aid Omeprazole:

benzyl alcohol, carmine, carnauba wax, FD&C blue #2/indigo carmine aluminum lake, flavor, hypromellose, hypromellose acetate succinate, lactose monohydrate, menthol, modified starch, monoethanolamine, polyethylene glycol 3350, sodium lauryl sulfate, sodium starch glycolate, sodium stearate, sodium stearyl fumarate, sucralose, talc, titanium dioxide, triacetin, triethyl citrate

Oh no...I messed up. Those were for a different version. The one I'm looking at is actually:

Active Ingredient: Omeprazole. Inactive Ingredients: Amino methacrylate copolymer, ascorbic acid, cetyl alcohol, colloidal silicon dioxide, crospovidone, ferric oxide, flavor, hypromellose, hypromellose phthalate, maize maltodextrin, mannitol, microcrystalline cellulose, propylene glycol, silicon dioxide, sodium stearate, sodium stearyl fumarate, sorbitol, sucralose, sugar spheres, talc, titanium dioxide, triethyl citrate.

 

I took it this AM and am having my gluten reaction, and am not familiar enough with ingredient lists yet to tell:(