Home test 3 times positive laboratory negative

[Victoria Bobnieva]

Hi! I did a celiac test (anti DGP Abs) from Amazon at home and it was 3 times positive. While I also did the same test for my parents and my grandma it was all negative for them. 
Later on I decided to do the same test at the laboratory and it showed negative. 
What should I do?

[OfcVal]

6 minutes ago, Victoria Bobnieva said:

Hi! I did a celiac test (anti DGP Abs) from Amazon at home and it was 3 times positive. While I also did the same test for my parents and my grandma it was all negative for them. 
Later on I decided to do the same test at the laboratory and it showed negative. 
What should I do?

 

Best to see a G.I.  Let them do the labs and endoscopy to confirm.  That way you can be sure if you have it or not. 

[trents]

2 minutes ago, Victoria Bobnieva said:

Hi! I did a celiac test (anti DGP Abs) from Amazon at home and it was 3 times positive. While I also did the same test for my parents and my grandma it was all negative for them. 
Later on I decided to do the same test at the laboratory and it showed negative. 
What should I do?

Welcome to the forum, Victoria.

The DGP test is considered a secondary test as it is not as accurate as the tTG-IGA. The tTG-IGA is the most common test that physicians order to check for celiac disease because it combines good specificity with good sensitivity. It is 98% accurate. Sometimes the DGP will catch those who do have celiac disease but whose immune systems respond atypically to the tTG-IGA. So, the DGP is useful in certain situations. Because it is not as accurate as the tTG-IGA, the DGP will more often be positive for reasons besides having celiac disease, some of them being transient. Also, I cannot vouch for the quality of the test you got on amazon.

What symptoms do you have and why did you order the DGP test online? Is there a reason you didn't go through a physician for testing?

[Victoria Bobnieva]

2 minutes ago, trents said:

Welcome to the forum, Victoria.

The DGP test is considered a secondary test as it is not as accurate as the tTG-IGA. The tTG-IGA is the most common test that physicians order to check for celiac disease because it combines good specificity with good sensitivity. It is 98% accurate. Sometimes the DGP will catch those who do have celiac disease but whose immune systems respond atypically to the tTG-IGA. So, the DGP is useful in certain situations. Because it is not as accurate as the tTG-IGA, the DGP will more often be positive for reasons besides having celiac disease, some of them being transient. Also, I cannot vouch for the quality of the test you got on amazon.

What symptoms do you have and why did you order the DGP test online? Is there a reason you didn't go through a physician for testing?

Because my doctor diagnosed me with IBS but I was trying to find by myself what can cause IBS. Cause I don’t believe in IBS without underlying problem.

[shadycharacter]

31 minutes ago, Victoria Bobnieva said:

Hi! I did a celiac test (anti DGP Abs) from Amazon at home and it was 3 times positive. While I also did the same test for my parents and my grandma it was all negative for them. 
Later on I decided to do the same test at the laboratory and it showed negative. 
What should I do?

Did you start to eat gluten free after the home test? If so, maybe the level of antibodies sank before the lab test.

[Victoria Bobnieva]

Just now, shadycharacter said:

Did you start to eat gluten free after the home test? If so, maybe the level of antibodies sank before the lab test.

I did … but it was so little… because I was afraid to eat more … I should’ve eat more I think… I have not had even a half of bread because it was making my stomach in pain… 

 

Just now, Victoria Bobnieva said:

I did … but it was so little… because I was afraid to eat more … I should’ve eat more I think… I have not had even a half of bread because it was making my stomach in pain… 

 

But there is a but… after laboratory test done the next day I tried a home test and it was positive …

[trents]

2 hours ago, Victoria Bobnieva said:

I did … but it was so little… because I was afraid to eat more … I should’ve eat more I think… I have not had even a half of bread because it was making my stomach in pain… 

 

But there is a but… after laboratory test done the next day I tried a home test and it was positive …

The Mayo Clinic guidelines for a pretest gluten challenge for those having eaten gluten free for a while is the daily consumption of two slices of wheat bread (or the gluten equivalent) for 6-8 weeks leading up to the day of the blood draw. Sounds like your second testing was negative because you had started eating gluten free already. You may also have NCGS instead of celiac disease.