Help with understanding test results

[jonathan31]

Celiac Disease Antibody Screen
Test Current Result and Flag Previous Result and Date Units Reference Interval
Immunoglobulin A, Qn,
Serum 01 157 mg/dL 90-386
Deamidated Gliadin Abs, IgA 01 6 units 0-19
Negative 0 - 19
Weak Positive 20 - 30
Moderate to Strong Positive >30
t-Transglutaminase (tTG) IgA 01 <2 U/mL 0-3
Negative 0 - 3
Weak Positive 4 - 10
Positive >10
Tissue Transglutaminase (tTG) has been identified
as the endomysial antigen. Studies have demonstr-
ated that endomysial IgA antibodies have over 99%
specificity for gluten sensitive enteropathy.
Allergen Profile, Basic Food
Test Current Result and Flag Previous Result and Date Units Reference Interval
Class Description 02
Levels of Specific IgE Class Description of Class
--------------------------- ----- --------------------
< 0.10 0 Negative
0.10 - 0.31 0/I Equivocal/Low
0.32 - 0.55 I Low
0.56 - 1.40 II Moderate
1.41 - 3.90 III High
3.91 - 19.00 IV Very High
19.01 - 100.00 V Very High
>100.00 VI Very High
F002-IgE Milk 02 <0.10 kU/L Class 0
F004-IgE Wheat 02 <0.10 kU/L Class 0
F008-IgE Corn 02 <0.10 kU/L Class 0
F013-IgE Peanut 02 <0.10 kU/L Class 0
F014-IgE Soybean 02 <0.10 kU/L Class 0
F026-IgE Pork 02 <0.10 kU/L Class 0
F027-IgE Beef 02 <0.10 kU/L Class 0
FX02-IgE Food Mix (Seafoods) 02 Negative
Allergens in this mix are:
Blue mussel
Fish
Date Created and Stored 08/09/23 2336 ET Final Re

[trents]

Welcome to the forum, jonathan31!

Everything you have posted seems to be negative or within normal range. Nothing is positive or high or abnormally low.

"Tissue Transglutaminase (tTG) has been identified
as the endomysial antigen. Studies have demonstr-
ated that endomysial IgA antibodies have over 99%
specificity for gluten sensitive enteropathy."

The quoted paragraph is not a test result. It is explaining the scientific basis for the kind of testing that was used.

 

Why were you having these tests run? Did you or your doctor suspect celiac disease or some gluten disorder? What symptoms were you having. A little history, please.

Edited August 10, 2023 by trents

[Wheatwacked]

Welcome to the forum Jonathan31.

What is your question?  What symptoms caused you to get the tests done?

Looks like your tests for Celiac Disease are all negative and same with allergens, except mussel and fish.

With Celiac and allergies ruled out the next step would be a trial gluten free diet to see if you get better.  If so, you might have Non Celiac Gluten Sensitivity.  No tests for it other than to rule out Celiac and show improvement with GFD.  What does the doc say?

[jonathan31]

yes they think gluten disorder. severe stomach pains after eating, bloating, my body is not absorbing nutrients they say.

[trents]

Actually, you only had two tests done of the several that are available to detect celiac disease. The two you had done were the Deamidated Gliadin Abs, IgA and the t-Transglutaminase (tTG) IgA.

The first one, Immunoglobulin A, Qn, Serum is a measure for total serum IGA which, if low, can cause false negatives in the specific IGA tests.

The other group of tests that were run are all for allergens which use an entirely different immune system pathway than does celiac disease which is not an allergy it is an autoimmune disorder.

So, you might consider going back to the doctor and asking for more thorough celiac disease testing, including: EMA and the DGP-IGG. These two were not done.

You might also seek an endoscopy with a biopsy of the small bowel to check for damage to the villous lining of the small bowel, the hallmark of celiac disease.

 

But I need to ask this very important question: Were you already on a gluten-free diet when the tests were run? If so, you invalidated the testing.

 

The other thing to look at is that you may have NCGS (Non Celiac Gluten Sensitivity). 10x more common than celiac disease but there is no test for it yet. NCGS would produce the symptoms you describe.

[Wheatwacked]

Had a Biopsy for Celiac Disease done?  Even with negative bloodwork there may still be intestinal villi damage.

Then you need to eat Gluten free and supplement vitamins and minerals.

Common deficiencies are vitamin D, Thiamine, Choline to start.  These should give you the quickest relief at a sufficient intake but there are twenty more essential vitamins that you need to be aware of.

severe stomach pains, bloat - Choline, causes symptoms often mistaken for gall bladder disease.

not absorbing nutrients  - 

 

TIN




 

VANADIUM1.8 mgND


 

 

[Russ H]

6 hours ago, trents said:

So, you might consider going back to the doctor and asking for more thorough celiac disease testing, including: EMA and the DGP-IGG. These two were not done.

 

EMA just detects tTG2 but with lower sensitivity and high specificity.

Isolated positive DGP-IgG, which it would be as the other tests were within the reference range, has very low predictive value for coeliac disease - perhaps 3-4%. It is commonly raised but at least 96-97% of raised results are false positives.

[trents]

28 minutes ago, Russ H said:

EMA just detects tTG2 but with lower sensitivity and high specificity.

Isolated positive DGP-IgG, which it would be as the other tests were within the reference range, has very low predictive value for coeliac disease - perhaps 3-4%. It is commonly raised but at least 96-97% of raised results are false positives.

But we sometimes have posters whose tTG-IGA is negative but their EGA is positive.

DGP-IgG is "commonly raised". Under what circumstances? Are you saying it is often raised whenever anyone is tested, regardless whether or not it is connected with a medical issue?