Newly diagnosed

[Michele Ann]

I’m new to this group and recently dx with Celiac Disease based on a positive biopsy; however, my IgA and IgG tests were negative.  I’ve had ongoing diarrhea for a year, malabsorption issues, anemia, osteoporosis, joint aches/pains, severe fatigue, IBS, SIBO, hypothyroidism, vitamin B, D , calcium, iron  deficiencies, and infertility. What is your interpretation of these results?  Is it possible to have celiac disease with negative lab tests?  

[trents]

Welcome to the forum, Michele Ann!

Can you post the complete names of the tests that were run, their scores and the reference ranges used for negative vs. positive? There are several tests that can be run in both the IgA group and the IgG group.

By some chance were you already on a gluten free diet when the blood draws were taken?

There are some other diseases, foods (dairy and oats, primarily) and medications that can cause damage to the small bowel villi and, therefore, would generate vitamin and mineral deficiencies.

https://www.joincyrex.com/the-cyrex-system/array-4-gluten-associated-cross-reactive-foods-foods-sensitivity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587842/#!po=13.7097

https://www.verywellhealth.com/villous-atrophy-562583

https://www.beyondceliac.org/research-news/cows-milk-protein-allergy-could-be-the-culprit-when-some-children-dont-recover-on-the-gluten-free-diet/?_hsmi=243747802&_hsenc=p2ANqtz-9ypIw1m3WkR8fel8zGzDTgLTyO4SkanPW8I3x0xu0RgLQFxBFcd_jA5Vwds15Uu0BiLLxTWgMkB91qdI1m7GTuv_hmzA

Are you on any meds like NDAIDs or blood pressure control agents?

The chances of it being something besides celiac disease that is causing damage to your villi are not great.

Edited August 15, 2023 by trents

[Michele Ann]

lgA Ab Value

UmL

Value <0.5

Standard

Range

<15.0 U/mL

Tissue Transglut

Ab, IgA Value Negative

Standard

Range

Negative

Negative: < 15 U/mL

Positive: >= 15 U/mL

Tissue

Transglutaminase

IgG Ab Value

U/mL

Value <0.8

Standard

Range

<15.0 U/mL

Tissue

Transglutaminase

Ab, IgG Vale Nedative

[trents]

You are not the first person on this forum to report negative serum antibody levels but a positive biopsy. Having said that, it's too bad that a more complete celiac panel was not run. There are other tests that could have been done and may have produced positive values.

But we are finding out more and more with time that celiac disease/NCGS (Non Celiac Gluten Sensitivity) has a number of expressive variations, some of which don't fit into our neat little diagnostic boxes.

[Scott Adams]

Have you gone on a gluten-free diet yet? If your symptoms go away on a gluten-free it would confirm your diagnosis.

[Michele Ann]

I started a strict gluten free diet 1 week ago. 

[Scott Adams]

You may notice the difference within days, as I did, but you should definitely notice symptom improvements withing a few weeks, if gluten is the cause of your symptoms. 

This article has some detailed information on how to be 100% gluten-free, so it may be helpful:

 

 

[Michele Ann]

I appreciate all of the comments.  Can someone tell me other blood tests that are used to test for Celiac disease other than IgG and IgA?  

[trents]

6 minutes ago, Michele Ann said:

I appreciate all of the comments.  Can someone tell me other blood tests that are used to test for Celiac disease other than IgG and IgA?  

All blood tests fall into those two main categories, IGA and IgG but within those two main categories there are multiple tests. I think the link in my above post explains all this.