@MMeade, People who get over-methylated are frequently low in Pyridoxine Vitamin B6.  Pyridoxine helps regulate the methylation process so it doesn't run amok.  P-5-P is the active form. All eight essential B vitamins work in concert together.  Just taking one or two can throw the rest out of balance.  If you have malabsorption as occurs in Celiac, then all the B vitamins will be poorly absorbed.  Taking a B Complex in addition to extra thiamine (Benfotiamine) is safe.  The B vitamins and Vitamin C are water soluble.  Any excess is urinated out.  I took a B 50 Complex twice a day to increase absorption.   Try taking Magnesium Threonate (Neuro-Mag by Life Extension).  Magnesium Threonate can get into the brain easily.  The brain needs magnesium, too, but other forms don't cross the blood-brain barrier as well.   The first time I took Magnesium Threonate, it felt like my brain relaxed.  I highly recommend it.   How's your Vitamin D level?  

@Rejoicephd, I took high dose Vitamin D to correct my severe  deficiency quickly.  It's safe to do this.  I felt much better once my Vitamin D level was about eighty ng/mL.   Vitamin D works as a hormone and helps calms the immune system between 80 - 100 ng/mL.    High-Dose Vitamin D Supplementation Can Correct Hypovitaminosis D Prior to Total Knee Arthroplasty https://pubmed.ncbi.nlm.nih.gov/34737019/ Yes, curious science brain here, too.  I studied Nutrition but switched to Microbiology because I was curious what the vitamins in food actually do in the body.  Lots more links in my blog here: Click on my name and look for activities menu.

Thanks @knitty kitty for keeping me thinking about the importance of vitamins. And I appreciate you sending those papers (gives me something for my science brain to work through! I’m a PhD in biology so I like reading these sorts of things). It’s been surprising to see how little is understood about the cause of fibromyalgia. My Vit D went low again on my last blood test so I know I’m back to being deficient there (it did go up for a while but back down again). Whomp whomp. So I’ll be both reading about and taking vitamins. Thanks again for your input. Really appreciate it.

Yes, that seems to be the gist. Quantifying residues in fermented foods and drinks seems to be difficult. There are no tests for total gluten, just immunoassays, which generally detect a single epitope. There are estimated to be approximately 50 sequences that evoke a T-cell response of which nearly half are unknown and have no test. Gluten fragments remain that bind to IgA and IgG in vitro but this does not necessarily make them immunotoxic. Also, the fragments are "drastically reduced" by gastrodudenal digestion. PEP enzyme cannot cleave all proline sites and there is a large variation in the amount of residual gluten in gluten reduced beers. I.e. the safety of gluten reduced beer is uncertain.  

Thank you so much @knitty kitty, I really appreciate all the feedback. I have had 2 biopsies of my small intestine that are negative for celiac disease. I have not had the genetic testing though, so that is something I will look into, since the biopsies were done without a prior gluten challenge. I tried one once before an allergy test and was sick for days. I do know that I don’t easily methylate my b vitamins but have to be careful taking methylated versions as they give me too much energy and I can’t sit still or sleep.    I also prefer magnesium glycinate but I only take it in the mornings because I have to take it with food to avoid stomach upset. I’ve often wondered if I have leaky gut syndrome and my symptoms indicate yes. I appreciate hearing what works well for you. I think I’ll focus on benfotiamine and see if I can tolerate it and/or it makes a difference. I really need to find a good nutritionist or naturopath. I’ll keep looking. In the meantime, thank you for your support!