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High IgA Normal TT IGA

haley630
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haley630 Newbie
haley630
Posted

 

Went to the GI yesterday. I have been having a weird burping issue for years. Ever since I had my little boy 5 years ago. I call it the silent burp because it stops in my throat if that makes sense. Other people if they are close to me can hear it and it drives my boyfriend crazy. It's all the time. My PCP told me it was anxiety like 4 years ago. I've had no other issues until about 6 months ago but it's been so bad the last few weeks. Severe bloating. Terrible gas. Feeling so nauseas. This was the only test result that was abnormal. TT IgA was within normal range. Any thoughts?

 

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haley630 Newbie
haley630
Posted
  • Author

Sorry forgot to put IgA. Normal range was 40-350. Mine is 960.

Scott Adams Grand Master
Scott Adams
Posted

It's too bad they didn't do a full celiac disease panel that included DGP-IgA and DGP-IgG (Deamidated Gliadin Peptide) tests.

This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. 

Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.

You may also want to ask your doctor why your total IgA is so high.

 

trents Grand Master
trents
Posted

Well, you with a total IGA score of almost 1000 you certainly aren't IGA deficient which is one thing that can suppress tTG-IGA scores. Some other things are that can suppress tTG-IGA are diabetes, thyroid disease, anemia and having a reduced gluten intake weeks in advance of the antibody test blood draw. But as Scott said, I would go back to your doctor and ask for a more complete celiac antibody panel including DGP-IGA and DGP-IGG.

Wheatwacked Veteran
Wheatwacked
Posted

You are not alone in this. Cant stop burping since having baby!! advice please

Thiamine deficiency can cause gas. Gastrointestinal Beriberi.

You might find these studies interesting.

Anti-Gliadin Antibodies Identify Celiac Patients Overlooked by Tissue Transglutaminase Antibodies 

"5 of 26 patients (20%) with biopsy-proven celiac disease during our specified period had a positive AGA IgA or IgG and a negative tTG... The most significant finding in our study was the identification of five patients with biopsy confirmed celiac disease that had negative tTG but positive AGAs."

Thiamine deficiency in pregnancy and lactation: implications and present perspectives

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    • knitty kitty
      Desperately need a vitamin D supplement. I've reacted to most brands I've tried.

      By knitty kitty · Posted

      @Jane02, I hear you about the kale and collard greens.  I don't do dairy and must eat green leafies, too, to get sufficient calcium.  I must be very careful because some calcium supplements are made from ground up crustacean shells.  When I was deficient in Vitamin D, I took high doses of Vitamin D to correct the deficiency quickly.  This is safe and nontoxic.  Vitamin D level should be above 70 nmol/L.  Lifeguards and indigenous Pacific Islanders typically have levels between 80-100 nmol/L.   Levels lower than this are based on amount needed to prevent disease like rickets and osteomalacia. We need more thiamine when we're physically ill, emotionally and mentally stressed, and if we exercise like an athlete or laborer.  We need more thiamine if we eat a diet high in simple carbohydrates.  For every 500 kcal of carbohydrates, we need 500-1000 mg more of thiamine to process the carbs into energy.  If there's insufficient thiamine the carbs get stored as fat.  Again, recommended levels set for thiamine are based on minimum amounts needed to prevent disease.  This is often not adequate for optimum health, nor sufficient for people with absorption problems such as Celiac disease.  Gluten free processed foods are not enriched with vitamins like their gluten containing counterparts.  Adding a B Complex and additional thiamine improves health for Celiacs.  Thiamine is safe and nontoxic even in high doses.  Thiamine helps the mitochondria in cells to function.  Thiamine interacts with each of the other B vitamins.  They are all water soluble and easily excreted if not needed. Interesting Reading: Clinical trial: B vitamins improve health in patients with coeliac disease living on a gluten-free diet https://pubmed.ncbi.nlm.nih.gov/19154566/ Safety and effectiveness of vitamin D mega-dose: A systematic review https://pubmed.ncbi.nlm.nih.gov/34857184/ High dose dietary vitamin D allocates surplus calories to muscle and growth instead of fat via modulation of myostatin and leptin signaling https://pubmed.ncbi.nlm.nih.gov/38766160/ Safety of High-Dose Vitamin D Supplementation: Secondary Analysis of a Randomized Controlled Trial https://pubmed.ncbi.nlm.nih.gov/31746327/ Vitamins and Celiac Disease: Beyond Vitamin D https://pmc.ncbi.nlm.nih.gov/articles/PMC11857425/ Investigating the therapeutic potential of tryptophan and vitamin A in modulating immune responses in celiac disease: an experimental study https://pubmed.ncbi.nlm.nih.gov/40178602/ Investigating the Impact of Vitamin A and Amino Acids on Immune Responses in Celiac Disease Patients https://pmc.ncbi.nlm.nih.gov/articles/PMC10814138/
    • Jane02
      Desperately need a vitamin D supplement. I've reacted to most brands I've tried.

      By Jane02 · Posted

      Thank you so much @knitty kitty for this insightful information! I would have never considered fractionated coconut oil to be a potential source of GI upset. I will consider all the info you shared. Very interesting about the Thiamine deficiency.  I've tracked daily averages of my intake in a nutrition software. The only nutrient I can't consistently meet from my diet is vitamin D. Calcium is a hit and miss as I rely on vegetables, dark leafy greens as a major source, for my calcium intake. I'm able to meet it when I either eat or juice a bundle of kale or collard greens daily haha. My thiamine intake is roughly 120% of my needs, although I do recognize that I may not be absorbing all of these nutrients consistently with intermittent unintentional exposures to gluten.  My vitamin A intake is roughly 900% (~6400 mcg/d) of my needs as I eat a lot of sweet potato, although since it's plant-derived vitamin A (beta-carotene) apparently it's not likely to cause toxicity.  Thanks again! 
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    • Scott Adams
      Desperately need a vitamin D supplement. I've reacted to most brands I've tried.

      By Scott Adams · Posted

      I do not know this, but since they are labelled gluten-free, and are not really a product that could easily be contaminated when making them (there would be not flour in the air of such a facility, for example), I don't really see contamination as something to be concerned about for this type of product. 
    • trents
      Desperately need a vitamin D supplement. I've reacted to most brands I've tried.

      By trents · Posted

      Contact them.
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