High IgA Normal TT IGA

[haley630]

 

Went to the GI yesterday. I have been having a weird burping issue for years. Ever since I had my little boy 5 years ago. I call it the silent burp because it stops in my throat if that makes sense. Other people if they are close to me can hear it and it drives my boyfriend crazy. It's all the time. My PCP told me it was anxiety like 4 years ago. I've had no other issues until about 6 months ago but it's been so bad the last few weeks. Severe bloating. Terrible gas. Feeling so nauseas. This was the only test result that was abnormal. TT IgA was within normal range. Any thoughts?

 

[haley630]

Sorry forgot to put IgA. Normal range was 40-350. Mine is 960.

[Scott Adams]

It's too bad they didn't do a full celiac disease panel that included DGP-IgA and DGP-IgG (Deamidated Gliadin Peptide) tests.

This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. 

Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.

You may also want to ask your doctor why your total IgA is so high.

 

[trents]

Well, you with a total IGA score of almost 1000 you certainly aren't IGA deficient which is one thing that can suppress tTG-IGA scores. Some other things are that can suppress tTG-IGA are diabetes, thyroid disease, anemia and having a reduced gluten intake weeks in advance of the antibody test blood draw. But as Scott said, I would go back to your doctor and ask for a more complete celiac antibody panel including DGP-IGA and DGP-IGG.

[Wheatwacked]

You are not alone in this. Cant stop burping since having baby!! advice please

Thiamine deficiency can cause gas. Gastrointestinal Beriberi.

You might find these studies interesting.

Anti-Gliadin Antibodies Identify Celiac Patients Overlooked by Tissue Transglutaminase Antibodies 

"5 of 26 patients (20%) with biopsy-proven celiac disease during our specified period had a positive AGA IgA or IgG and a negative tTG... The most significant finding in our study was the identification of five patients with biopsy confirmed celiac disease that had negative tTG but positive AGAs."

Thiamine deficiency in pregnancy and lactation: implications and present perspectives