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High blood test numbers - with scales. Any advice?


TexasCeliacNewbie

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TexasCeliacNewbie Newbie

Hi, I have been having a lot of back pain and gut issues for 8 weeks or so.  I saw the GI on Monday and my results just came in from the lab.  Some of these number are high and off the little chart from the lab.  I am reading this correctly that I most likely have Celiac, right???  It would explain a lot of things for me.  She does have me scheduled for a colonoscopy and endoscopy in  2 weeks to do the biopsy.  I posted this prior, but forgot to put the range assuming they were all the same.  Someone advised me to repost with the ranges for some insight in the meantime.

Immunoglobulin A, Qn, Serum 140 (normal) - Normal is 87-352

Deamidated Gliadin Abs, IgA 256 (High) - Moderate to strong positive at or above 30

Deamidated Gliadin Abs, IgG 65 (High) - Moderate to strong positive at or above 30

t-Transglutaminase (tTG) IgA 31 (High) - Moderate to strong positive above 10

t-Transglutaminase (tTG) IgG 10 (High) - Positive is at or above 10


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TexasCeliacNewbie Newbie

I do also have the bloating, gas, constipation, hair loss, an auto-splenectomy that no one can see any reason for and some elevated liver enzymes that don't seem to have a cause, I also have joint pain and some spinal compression fractures that have no explanation.  I am only 42 so haven't had a bone density test yet.  My calcium was normal, but my D was a little low.  They haven't checked for any other vitamin deficiencies yet.  My blood test for an autoimmue disorder was quite high but my Thyroid was all normal.

RMJ Mentor

I’d say celiac is likely.  Please continue to eat plenty of gluten until your endoscopy to be sure that any gluten-related damage can be seen.  Plus it gives you one last chance to enjoy your favorite gluten-containing foods.

I hope the endoscopy/biopsies give you a definitive answer. 

Scott Adams Grand Master

I agree with @RMJ, you have multiple positive tests so celiac disease is likely. 

This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. 

 

 

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    • Scott Adams
      To me it seems like a slam dunk diagnosis, and the actual confirmation should be recovery on a gluten-free diet. If her symptoms improve on the diet, it would be final confirmation that she has celiac disease--and likely DH as well.
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    • Scott Adams
      It is shocking that you were apparently not informed about this positive celiac disease test. In the Europe the protocol for making a celiac disease diagnosis in children is if their tTg-IgA (tissue transglutaminase IgA) levels are 10 times or above the positive level for celiac disease. According to the latest research, if the blood test results are at certain high levels that range between 5-10 times the reference range for a positive celiac disease diagnosis, it may not be necessary to confirm the results using an endoscopy/biopsy: Blood Test Alone Can Diagnose Celiac Disease in Most Children and Adults TGA-IgA at or Above Five Times Normal Limit in Kids Indicates Celiac Disease in Nearly All Cases No More Biopsies to Diagnose Celiac Disease in Children!    
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