Negative Biopsy?

[Totsy]

Hi. I'm new, but have reading the forum for over a year. My daughter who is 17 was diagnosed as possibly having celiac disease when I took her into a GI for constipation and blood on her stool. Other than those two symptoms she felt great. He did a blood test and then scheduled her for a colonoscopy. The blood test came back with a Ttg of 69 and he said he should do an endoscopy to test for a wheat allergy. The biopsy came back negative, the villi were not damaged, but the colonoscopy showed ulcerative proctitis. She's been gluten free for a year, but since she has never had symptoms it's hard to say whether or not she actually has celiac. Could ulcerative proctitis cause an elevated Ttg?

Any light anyone can shed on this would be much appreciated!

Totsy

[gfp]

Hi. I'm new, but have reading the forum for over a year. My daughter who is 17 was diagnosed as possibly having celiac disease when I took her into a GI for constipation and blood on her stool. Other than those two symptoms she felt great. He did a blood test and then scheduled her for a colonoscopy. The blood test came back with a Ttg of 69 and he said he should do an endoscopy to test for a wheat allergy. The biopsy came back negative, the villi were not damaged, but the colonoscopy showed ulcerative proctitis. She's been gluten free for a year, but since she has never had symptoms it's hard to say whether or not she actually has celiac. Could ulcerative proctitis cause an elevated Ttg?

Any light anyone can shed on this would be much appreciated!

Totsy

If this was the only test done then its not much to go on. If you have other test results it would help, if not then you should probably get them done.

A negative biopsy by itself doesn't mean much... it could mean bad sampling, it could mean she is lucky and not yet damaged but reacting or it could mean its something else completely.

[Debbie65]

As gfp already said, a negative biopsy doesn´t tell you much. I have Celiac and had a negative biopsy at around the age of 25ish.

For the sake of other regulars on the board I won´t go into details I´ve already stated but my signiture gives a brief explanation.

[jbuckeye]

Hi--I was recently diagnosed and wanted to say that I had a tTg of 79 and duodenal scalloping shown during endoscopy, but my biopsy at first came back negative. My doctor told the lab--no way, look again, and lo and behold, partial villi atrophy was found.

My doctor (gastroenterologist associated with a big university hospital) said that she sees few false positive tTg's. I don't know if this helps you, but I wanted to tell you my diagnosis story.