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Question Regarding Positive Blood Tests

Helena

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Helena Contributor
Helena
Posted

If people test positive for the serological markers for celiac disease, dr.'s generally recommend the biopsy while the patient is still on a gluteny diet---if the biopsy is negative, they decide that the patient does not have celiac.

What I don't get is how they explain the positive blood test results. In my understanding (and I might be entirely wrong here--correct me if I am) if you put anti-tTG in a test tube along with tissue transglutaminase the autoantigen (anti-tTG) will attack the enzyme (tTG). So wouldn't that mean that regardless of the state of the villi that anti tissue transglutaminase is initiating an autoimmune response??

I should add that the answer to this question has no bearing on my life whatsoever. I'm just trying to make sense of the medical system which really doesn't make sense to me sometimes!

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Matilda Enthusiast
Matilda
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      Disaccharide deficient, confusing biopsy results, no blood test

      By trents · Posted

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      By jenniber · Posted

      hi, i want to say thank you to you and @trents   . after 2 phone calls to my GI, her office called me back to tell me that a blood test was “unnecessary” and that we should “follow the gold standard” and since my biopsy did not indicate celiac, to follow the no dairy and sucraid diet. i luckily have expendable income and made an appt for the labcorp blood test that day. i just got my results back and it indicates celiac disease i think 😭   im honestly happy bc now i KNOW and i can go gluten free. and i am SO MAD at this doctor for dismissing me for a simple blood test that wouldn’t have cost her anything !!!!!!!!!!! im sorry, im so emotional right now, i have been sick my whole life and never knew why, i feel so much better already   my results from labcorp:   Celiac Ab tTG TIgA w/Rflx Test Current Result and Flag Previous Result and Date Units Reference Interval t-Transglutaminase (tTG) IgA 01 28 High U/mL 0-3 Negative 0 - 3 Weak Positive 4 - 10 Positive >10 Tissue Transglutaminase (tTG) has been identified as the endomysial antigen. Studies have demonstrated that endomysial IgA antibodies have over 99% specificity for gluten sensitive enteropathy. Immunoglobulin A, Qn, Serum 01 245 mg/dL 87-352
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      By Samanthaeileen1 · Posted

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      By GlorietaKaro · Posted

      One doctor suggested it, but then seemed irritated when I asked follow-up questions. Oh well—
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