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Question Regarding Positive Blood Tests

Helena

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Helena Contributor
Helena
Posted

If people test positive for the serological markers for celiac disease, dr.'s generally recommend the biopsy while the patient is still on a gluteny diet---if the biopsy is negative, they decide that the patient does not have celiac.

What I don't get is how they explain the positive blood test results. In my understanding (and I might be entirely wrong here--correct me if I am) if you put anti-tTG in a test tube along with tissue transglutaminase the autoantigen (anti-tTG) will attack the enzyme (tTG). So wouldn't that mean that regardless of the state of the villi that anti tissue transglutaminase is initiating an autoimmune response??

I should add that the answer to this question has no bearing on my life whatsoever. I'm just trying to make sense of the medical system which really doesn't make sense to me sometimes!

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Matilda Enthusiast
Matilda
Posted

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      Thank you that’s really helpful, hopeful won’t have to have a biopsy.
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      That means the normal range (i.e. not celiac disease) would be a result less than 14.99.  Your result is WAY above that. Some gastroenterologists would diagnose that as celiac disease even without a confirming biopsy because it is more than ten times the top of the normal range.
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      Thank you. These were the results TTG ABS NUMERICAL: > 250.0 U/mL [< 14.99]  Really don’t understand the results!
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