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High Igg Levels/negative Everything Else

fisherl6

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fisherl6 Newbie
fisherl6
Posted

i have just started reading this board and it has been very helpful so far. I just got some labwork back, my gliadin IGG level was 48, where >30 is a strong positve, my IgA levels were negative as well as TTG. I saw some post saying that a elevated IgG level could be related to other things, can anyone elaborate on that.?

My history is I am 24, I have been feeling fatigued/moody/brain foggy for the last few years, after seeing a few different doctors, i finally got a thryoid panel and found out I have a Hashimatos disease (autoimmune thyroid problem causing hypothyroidism). They medicine has made me feel a lot better with the moodiness and constant weight gain, but I still have pretty bad bouts of fatigue (at least for someone who used to be very active). Also I have always had a "bad stomach" (bouts of diarehhia, cramping constant bloating, soreness in my lower abdomen), so I finally went to see a GI doctor, after deciding I probably just had mild IBS, i asked him to get an autoimmune panel since I have heard people with one autoimmune problem tend to have others. Anyway, I just got the labs back, I am not sure what all of the test performed are (Endomysial AB, Transglutaminase IGA, and Gliadin Antibodies) but the only high value is the Gliadin IgG. The other thing is I have a kind of low wheat intake already, maybe a piece of bread a day, but mostly protein and veggies and I have noticed that makes me feel better.

Sorry for the long posting, just wondering if anyone had any similar experiences and maybe someone could explain the IGG better. Thanks

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tarnalberry Community Regular
tarnalberry
Posted

My only non-negative test was anti-reticulin IgG. I too have heard that elevated IgG's can be related to "other things" but have still never found any actual "things" that it is related to. (I've looked... nothing...) The low gluten consumption could affect your test results, and unless you plan to get a biopsy, I can only suggest going completely off gluten for a while, and - if you're feeling brave - do a dietary challenge (have some pasta - not bread since it has other things you could react to) and see how it goes.

  • 4 years later...
HebrewRose Newbie
HebrewRose
Posted

I have the same problem. My gliadin IgG is 52.0 (ref 0-10) but everything else is normal. I have terrible GI symptoms as well as fatigue and moodiness. Plus there's a family history of celiac disease. I can't find any other condition linked to levels like these either. I have an appointment with my doctor in two days, so if I find anything further, I'll update, but I read a study that said about 20% of celiac disease cases are shown to be IgA deficient, so we could just be a part of that lucky percentage.

ShayFL Enthusiast
ShayFL
Posted

Did they run TOTAL IgA to see if you are deficient?

Fiddle-Faddle Community Regular
Fiddle-Faddle
Posted

I had the same blood test results, but was gluten-free at the time of the test.

Also wondering if it could have something to do with Eastern European/Jewish heredity????

Mtndog Collaborator
Mtndog
Posted

I also was diagnosed by IgG and positive response to the diet. I later found out I had one of the genes as well (HLA DQ8).

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    • knitty kitty
      High DGP-A with normal IGA

      By knitty kitty · Posted

      @rei.b,  I understand how frustrating starting a new way of eating can be.  I tried all sorts of gluten-free processed foods and just kept feeling worse.  My health didn't improve until I started the low histamine AIP diet.  It makes a big difference.   Gluten fits into opioid receptors in our bodies.  So, removing gluten can cause withdrawal symptoms and reveals the underlying discomfort.  SIBO can cause digestive symptoms.  SIBO can prevent vitamins from being absorbed by the intestines.  Thiamine insufficiency causes Gastrointestinal Beriberi (bloating, abdominal pain, nausea, diarrhea or constipation).  Thiamine is the B vitamin that runs out first because it can only be stored for two weeks.  We need more thiamine when we're sick or under emotional stress.  Gastric Beriberi is under recognised by doctors.  An Erythrocyte Transketolace Activity test is more accurate than a blood test for thiamine deficiency, but the best way to see if you're low in thiamine is to take it and look for health improvement.  Don't take Thiamine Mononitrate because the body can't utilize it well.  Try Benfotiamine.  Thiamine is water soluble, nontoxic and safe even at high doses.  I thought it was crazy, too, but simple vitamins and minerals are important.  The eight B vitamins work together, so a B Complex, Benfotiamine,  magnesium and Vitamin D really helped get my body to start healing, along with the AIP diet.  Once you heal, you add foods back in, so the AIP diet is worth doing for a few months. I do hope you'll consider the AIP diet and Benfotiamine.
    • captaincrab55
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    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

      Okay well the info about TTG-A actually makes a lot of sense and I wish the PA had explained that to me. But yes, I would assume I would have intestinal damage from eating a lot of gluten for 32 years while having all these symptoms. As far as avoiding gluten foods - I was definitely not doing that. Bread, pasta, quesadillas (with flour tortillas) and crackers are my 4 favorite foods and I ate at least one of those things multiple times a day e.g. breakfast with eggs and toast, a cheese quesadilla for lunch, and pasta for dinner, and crackers and cheese as a before bed snack. I'm not even kidding.  I'm not really big on sugar, so I don't really do sweets. I don't have any of those conditions.  I am not sure if I have the genes or not. When the geneticist did my genetic testing for EDS this year, I didn't think to ask for him to request the celiac genes so they didn't test for them, unfortunately.  I guess another expectation I had is  that if gluten was the issue, the gluten-free diet would make me feel better, and I'm 3 months in and that hasn't been the case. I am being very careful and reading every label because I didn't want to screw this up and have to do gluten-free for longer than necessary if I end up not having celiac. I'm literally checking everything, even tea and anything else prepacked like caramel dip. Honestly its making me anxious 😅
    • knitty kitty
      High DGP-A with normal IGA

      By knitty kitty · Posted

      So you're saying that you think you should have severe intestinal damage since you've had the symptoms so long?   DGP IgG antibodies are produced in response to a partial gluten molecule.  This is different than what tissue transglutaminase antibodies are  produced in response to.   TTg IgA antibodies are produced in the intestines in response to gluten.  The tTg IgA antibodies attack our own cells because a structural component in our cell membranes resembles a part of gluten.  There's a correlation between the level of intestinal damage with the level of tTg antibodies produced.  You are not producing a high number of tTg IgA antibodies, so your level of tissue damage in your intestines is not very bad.  Be thankful.   There may be reasons why you are not producing a high quantity of tTg IgA antibodies.  Consuming ten grams or more of gluten a day for two weeks to two months before blood tests are done is required to get sufficient antibody production and damage to the intestines.  Some undiagnosed people tend to subconsciously avoid lots of gluten.  Cookies and cakes do not contain as much gluten as artisan breads and thick chewy pizza crust.  Anemia, diabetes and thiamine deficiency can affect IgA antibody production as well.   Do you carry genes for Celiac?  They frequently go along with EDS.
    • rei.b
      High DGP-A with normal IGA

      By rei.b · Posted

      I was tested for celiac at the same time, so I wasn't taking naltrexone yet. I say that, because I don't. The endoscopy showed some mild inflammation but was inconclusive as to celiac disease. They took several biopsies and that's all that was shown. I was not given a Marsh score.
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