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Ema Test?


kpyoung24

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kpyoung24 Rookie

Hi everyone! im new here..... after taking my 7 year old daughter to her pcp with gi symptoms the doc ran two celiac disease tests.. the gliadin and the endomysial(ema) tests. they called two days later with results saying that both tests came back "elevated" and that she probably has celiac but that the diagnosis needs to be confirmed by a gi specialist. i spoke with the gi nurse and she said that the EMA test is pretty specific to celiac disease and that's most likely the diagnosis we are facing but that the gi doc will decide to run the transglutiminase (or however its spelled, lol) test or proceed with the biopsy based on the lab work that the pcp ordered. i guess what im looking for is any info anyone can give me as to whether or not the EMA test is pretty definitive, and if the biopsy is necessary. i know there are many different opinions on this, anything would be appreciated! thanks!!!! kimberly


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GlutenWrangler Contributor

Kimberly,

The Endomysial Antibody test is very specific for Celiac Disease. Your son's blood test results are conclusive for Celiac Disease. A biopsy is not necessary if you don't want to put your son through it. Some gastroenterologists would just diagnose your son with Celiac Disease with just those test results, and not even bother with a biopsy. A biopsy is useful if you want to determine the level of villi destruction, but it's definitely not necessary at this point for a diagnosis. Hope this helps.

-Brian

kpyoung24 Rookie
Kimberly,

The Endomysial Antibody test is very specific for Celiac Disease. Your son's blood test results are conclusive for Celiac Disease. A biopsy is not necessary if you don't want to put your son through it. Some gastroenterologists would just diagnose your son with Celiac Disease with just those test results, and not even bother with a biopsy. A biopsy is useful if you want to determine the level of villi destruction, but it's definitely not necessary at this point for a diagnosis. Hope this helps.

-Brian

hi brian! thank you very much for your reply! it helps a lot! another question i have is about the biopsy. the tests that were run on my daughter included what the doc referred to as the basic stuff, which she said was like thyroid, elektrolytes etc.... these tests were all "normal", does this indicate that she has little or no villi damage thus far? if so doesn't that make the biopsy completely unnecessary??~K

happygirl Collaborator

The rest of your bloodwork can be fine and your villi can be completely flattened.

The other purpose of an endoscopy is to look for other problems that are causing symptoms.

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    • jenniber
      hi, i want to say thank you to you and @trents   . after 2 phone calls to my GI, her office called me back to tell me that a blood test was “unnecessary” and that we should “follow the gold standard” and since my biopsy did not indicate celiac, to follow the no dairy and sucraid diet. i luckily have expendable income and made an appt for the labcorp blood test that day. i just got my results back and it indicates celiac disease i think 😭   im honestly happy bc now i KNOW and i can go gluten free. and i am SO MAD at this doctor for dismissing me for a simple blood test that wouldn’t have cost her anything !!!!!!!!!!! im sorry, im so emotional right now, i have been sick my whole life and never knew why, i feel so much better already   my results from labcorp:   Celiac Ab tTG TIgA w/Rflx Test Current Result and Flag Previous Result and Date Units Reference Interval t-Transglutaminase (tTG) IgA 01 28 High U/mL 0-3 Negative 0 - 3 Weak Positive 4 - 10 Positive >10 Tissue Transglutaminase (tTG) has been identified as the endomysial antigen. Studies have demonstrated that endomysial IgA antibodies have over 99% specificity for gluten sensitive enteropathy. Immunoglobulin A, Qn, Serum 01 245 mg/dL 87-352
    • JoJo0611
      Thank you this really helped. 
    • Samanthaeileen1
      Okay that is really good to know. So with that being positive and the other being high it makes sense she diagnosed her even without the endoscopy. So glad we caught it early. She had so many symptoms though that to me it was clear something was wrong.   yeah I think we had better test us and the other kids as well. 
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      One doctor suggested it, but then seemed irritated when I asked follow-up questions. Oh well—
    • trents
      @GlorietaKaro, your respiratory reactions to gluten make me wonder if there might also be an allergic (anaphylaxis) component at work here.
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