Entero Lab Results

[darcijj]

I got my results from Entero Labs today:

Final Laboratory Report

Date: 4/10/2008

A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value

Fecal Antigliadin IgA 9 (Normal Range <10 Units)

Fecal Antitissue Transglutaminase IgA 9 Units (Normal Range <10 Units)

Quantitative Microscopic Fecal Fat Score <300 Units (Normal Range <300 Units)

Fecal anti-casein (cow's milk) IgA antibody 7 Units (Normal Range <10 Units)

HLA-DQB1 Molecular analysis, Allele 1 0201

HLA-DQB1 Molecular analysis, Allele 2 0501

Serologic equivalent: HLA-DQ 2,1 (Subtype 2,5)

Interpretation of Fecal Antigliadin IgA: Intestinal antigliadin IgA antibody was below the upper limit of normal, and hence there is no direct evidence of active gluten sensitivity from this test. However, because 1 in 500 people cannot make IgA at all, and rarely, and some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have a syndrome or symptoms known to be associated with gluten sensitivity, a gluten-free diet may help you despite a negative test. If you have no syndrome or symptoms associated with gluten sensitivity, you can follow a gluten-containing healthy diet and retest in 3-5 years; or you may opt to go gluten-free as a purely preventive measure.

Interpretation of Fecal Antitissue Transglutaminase IgA: The level of intestinal IgA antibodies to the human enzyme tissue transglutaminase was below the upper limit of normal, and hence, there is no evidence of a gluten-induced autoimmune reaction.

Interpretation of Quantitative Microscopic Fecal Fat Score: Provided that dietary fat is being ingested, a fecal fat score less than 300 indicates there is no malabsorbed dietary fat in stool indicating that digestion and absorption of nutrients is currently normal.

Interpretation of Fecal anti-casein (cow's milk) IgA antibody: Levels of fecal IgA antibody to a food antigen greater than or equal to 10 are indicative of an immune reaction, and hence immunologic "sensitivity" to that food. For any elevated fecal antibody level, it is recommended to remove that food from your diet. Values less than 10 indicate there currently is minimal or no reaction to that food and hence, no direct evidence of food sensitivity to that specific food.

However, because 1 in 500 people cannot make IgA at all, and rarely, some people can still have clinically significant reactions to a food antigen despite the lack of a significant antibody reaction (because the reactions primarily involve T cells), if you have an immune syndrome or symptoms associated with food sensitivity, it is recommended that you try a strict removal of suspect foods from your diet for up to 12 months despite a negative test.

Interpretation Of HLA-DQ Testing: HLA-DQB1 gene analysis reveals that you have one of the main genes that predisposes to gluten sensitivity and celiac sprue, HLA-DQB1*0201 or HLA-DQB1*0302. Each of your offspring has a 50% chance of receiving this gene from you, and at least one of your parents passed it to you.

You also have a non-celiac gene predisposing to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having one celiac gene and one gluten sensitive gene, means that each of your parents, and all of your children (if you have them) will possess at least one copy of a gluten sensitive gene.

Having two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe.

So I think good possibility it is gluten sensitivity.. but I can develop Celiacs since I have the gene. What do you think?

Also today.. this came in the mail from the GI office:

It reads:

the following are the pertinent results from your recent lab tests. (Lab Results) Laboratory results show no signs of Celiac disease. Excellent report.

That is all it says, no values or what specific blood tests were used. The results correspond to the Entro labs.. I do not have the anitbodies.. but does not mean I am not gluten sensitive or may develop Celiac!

I have been gluten free for 3 weeks now and feel really good.. cannot remember the last time I felt this good.

[Ursa Major]

Well, unless you are IgA deficient (which should be tested) you should theoretically not have a problem with gluten right now. Of course, since you have a celiac disease gene, you might develop celiac disease in the future.

But really, trying the diet is the most important test. And since you feel much better on the gluten-free diet, you will likely be better off sticking to it. One good thing about that is, that it will prevent you from developing full-blown celiac disease in the future.

Besides, I believe that gluten isn't good for anybody, and you are better off avoiding it anyway.

[mftnchn]

Perhaps you have another condition causing leaky gut syndrome and leading to gluten sensitivity. So it might be good to look into other possibilities. Parasites maybe? Allergies perhaps.

A couple of other possibilities I have read on the forum are lyme disease and metal toxicity, as well as enzyme deficiencies.

[darcijj]

Thanks for the replies!

I have gone through many rounds of testing since December.. (symptoms were going on for a long time before that)

Tested for:

MS

Lyme Disease

Heavy Metal Poisoning

B12

lupus

And a few others that I do not know what they are.

All tests come up negative. The GI doc said I have IBS.. wants to do a colonoscopy. But I do not need it.. All those symptoms are gone now.

Even though the tests for gluten are negative.. I feel better without it.. and I really see no reason to eat it at this point.

[mftnchn]

Great, you may have already found the answer.

If, however, you have a return of symptoms, post again. There are people here who may have ideas for you. For example, if you post your lyme disease tests and results, you'll get lots of good feedback. The best of the lyme tests are at least 30% false negative and most labs are 50-60% false negative. Also the labs and most doctors use the wrong criteria to read the tests.

Best wishes and be well.

[Wonka]

Besides, I believe that gluten isn't good for anybody, and you are better off avoiding it anyway.

I went to a celiac seminar last weekend and the speaker, a paediatric GI specialist, said that wheat is toxic to everyone but that people with celiac disease are just more sensitive to it. I found that really interesting.

[feelingbetter]

How long did it take to get your entero results? I sent mine in on March 25 and still nothing. In 3 days it will be 3 weeks. Maybe I am just too anxious.

[cyberprof]

How long did it take to get your entero results? I sent mine in on March 25 and still nothing. In 3 days it will be 3 weeks. Maybe I am just too anxious.

My son got his in March 2 days before the 3 weeks were up. I think others have posted that they really do mean 3 weeks when they say 3. Call them on Tuesday if you don't hear. And let us know your result! Good luck.

~Laura

[darcijj]

I took 3 weeks exactly from the date they received the samples. The waiting is the hard part.

D

[feelingbetter]

This waiting has been miserable. Even though I am gluten and dairy free I can't wait to know for sure.

Thanks