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Gene Test Results- Quick Help Please

ItchyMeredith

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ItchyMeredith Contributor
ItchyMeredith
Posted

HLA-DQB1 Molecular analysis, Allele 1 0201

HLA-DQB1 Molecular analysis, Allele 2 0603

Serologic equivalent: HLA-DQ 2,1 (Subtype 2,6)

Interpretation Of HLA-DQ Testing: HLA-DQB1 gene analysis reveals that you have one of the main genes that predisposes to gluten sensitivity and celiac sprue, HLA-DQB1*0201 or HLA-DQB1*0302. Each of your offspring has a 50% chance of receiving this gene from you, and at least one of your parents passed it to you. You also have a non-celiac gene predisposing to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having one celiac gene and one gluten sensitive gene, means that each of your parents, and all of your children (if you have them) will possess at least one copy of a gluten sensitive gene. Having two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe.

What does this mean to you? I read the Enterolab explanation but I still don't completely get it.

Thanks for your help!

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happygirl Collaborator
happygirl
Posted

HLA-DQB1 Molecular analysis, Allele 1 0201 is HLA DQ 2, which is a Celiac gene.

Enterolab says the other one is a gluten sensitive gene. There is considerably less research or consensus on this (at this point).

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ItchyMeredith Contributor
ItchyMeredith
Posted
  • Author

This test was for my son who is 3. The bottom line is that he MAY have celiac- correct??

aikiducky Apprentice
aikiducky
Posted

It means that genetically, it's possible for him to develop celiac. Whether or not he does is another question.

Pauliina

happygirl Collaborator
happygirl
Posted

about 30% of the population has the gene(s), but only 1 in 133 has Celiac.

the risk of having Celiac increases when you have a person in your family diagnosed with Celiac. However, it doesn't mean he will get it. And, if he "will" get it, you don't know if he'll get it as a kid, as a teen, a young adult.....or be 80 years old. He might not have it now....but could have it later.

Only way to know for sure is blood tests/biopsy. If you are looking for resolution of symptoms, it may be worth it to try a gluten free diet after testing is complete.

ItchyMeredith Contributor
ItchyMeredith
Posted
  • Author

Yeah- I am pretty sure it HAS turned on. His bloodwork a year ago was negative- but it often is with children his age. He is showing a number of questionable symptoms and these were his Enterolab results:

A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value

Fecal Antigliadin IgA 41 (Normal Range <10 Units)

Fecal Antitissue Transglutaminase IgA 31 Units (Normal Range <10 Units)

Quantitative Microscopic Fecal Fat Score 1158 Units (Normal Range <300 Units)

Fecal anti-casein (cow

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