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What Does A Biopsy Tell You?


B'sgirl

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B'sgirl Explorer

My son is two and has some definite intolerances. Will a biopsy tell you specific things that bother him, or just whether or not there are damaged villi? I can tell for sure that gluten, casein, whey, and corn bother him. He has been to an allergist and they are not allergies. I'm fairly sure it's Celiac even though his blood test came up negative. I just want to know if there is anything else I need to avoid. What benefit could I expect from a biopsy?


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ShayFL Enthusiast

Unfortunately a biopsy cannot tell what specific intolerances have caused damage. Other foods can rarely cause flattened villi, but most often a food culprit is gluten. While they are in there, they often look for other things. Ulcers, damage to the esophagus, etc.

Enterolab does a stool test for intolerances: Gluten, Dairy, Egg, Soy and Yeast. They also do genetic testing for Celiac and Gluten Intolerance genes. They cannot Dx Celiac, but can give more information on what to avoid (as that is what you are looking for). A few people even got there insurance to pay for it.

Lisa Mentor

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c2shopping Newbie

I can speak from my experience - which, is that it told me nothing. I was positive diagnosed via Entero Lab after being given a clean bill of health from the endoscopy. I later learned that dr.s that perform endoscopy tend to diagnose only full blown disease; hence, if you have gotten to the point of drastically damaging your intestines they can see it. If you are ill, but not 1/2 dead they cant.

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    • trents
      So the tTG-IGA at 28 is positive for celiac disease. There are some other medical conditions that can cause elevated tTG-IGA but this is unlikely. There are some people for whom the dairy protein casein can cause this but by far the most likely cause is celiac disease. Especially when your small bowel lining is "scalloped". Your Serum IGA 01 (aka, "total IGA") at 245 mg/dl is within normal range, indicating you are not IGA deficient. But I also think it would be wise to take your doctor's advice about the sucraid diet and avoiding dairy . . . at least until you experience healing and your gut has had a chance to heal, which can take around two years. After that, you can experiment with adding dairy back in and monitor symptoms. By the way, if you want the protein afforded by dairy but need to avoid casein, you can do so with whey protein powder. Whey is the other major protein in dairy.
    • jenniber
      hi, i want to say thank you to you and @trents   . after 2 phone calls to my GI, her office called me back to tell me that a blood test was “unnecessary” and that we should “follow the gold standard” and since my biopsy did not indicate celiac, to follow the no dairy and sucraid diet. i luckily have expendable income and made an appt for the labcorp blood test that day. i just got my results back and it indicates celiac disease i think 😭   im honestly happy bc now i KNOW and i can go gluten free. and i am SO MAD at this doctor for dismissing me for a simple blood test that wouldn’t have cost her anything !!!!!!!!!!! im sorry, im so emotional right now, i have been sick my whole life and never knew why, i feel so much better already   my results from labcorp:   Celiac Ab tTG TIgA w/Rflx Test Current Result and Flag Previous Result and Date Units Reference Interval t-Transglutaminase (tTG) IgA 01 28 High U/mL 0-3 Negative 0 - 3 Weak Positive 4 - 10 Positive >10 Tissue Transglutaminase (tTG) has been identified as the endomysial antigen. Studies have demonstrated that endomysial IgA antibodies have over 99% specificity for gluten sensitive enteropathy. Immunoglobulin A, Qn, Serum 01 245 mg/dL 87-352
    • JoJo0611
      Thank you this really helped. 
    • Samanthaeileen1
      Okay that is really good to know. So with that being positive and the other being high it makes sense she diagnosed her even without the endoscopy. So glad we caught it early. She had so many symptoms though that to me it was clear something was wrong.   yeah I think we had better test us and the other kids as well. 
    • GlorietaKaro
      One doctor suggested it, but then seemed irritated when I asked follow-up questions. Oh well—
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