Need Help With Genetic Test Results

[wahmmy]

We did the genetic tests on our two daughters, ages 5 and 2, with Enterolab. We just got the results back and they were the same for both daughters. I'm having trouble interpreting them despite all the info provided from the website link provided. Could you help me? Thanks!

Also, I take this to mean that I have at least one gluten sensitivity gene? My husband is the one with Celiac, diagnosed through blood work and a biopsy a couple of months ago. His father also has Celiac.

Should we test them further at this point? What about myself?

And the severity issue of immunological response -- does that mean that lymphoma and some of those other issues are still a risk even if it's not Celiac? (Because I'm taking it that they won't get Celiac with these results?) What about nutritional deficiencies? Are these not a risk if Celiac damage isn't being done? Is it just they may have bad symptoms but not the actual intermal damage? Sorry for all the questions!

Gluten Sensitivity Gene Test

HLA-DQB1 Molecular analysis, Allele 1 0301

HLA-DQB1 Molecular analysis, Allele 2 0303

Serologic equivalent: HLA-DQ 3,3 (Subtype 7,9)

Interpretation Of HLA-DQ Testing: Although you do not possess the main HLA-DQB1 genes predisposing to celiac sprue (HLA-DQB1*0201 or HLA-DQB1*0302), HLA gene analysis reveals that you have two copies of a gene that predisposes to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having two copies of a gluten sensitive gene means that each of your parents and all of your children (if you have them) will possess at least one copy of the gene. Two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity may be more severe.

For more information about result interpretation, please see Open Original Shared Link

[nora-n]

There are some celiacs here with either of these genes. I think someone even asked about this comination recently.

[ShayFL]

Nora is right. There are dx'd Celiacs with this genetic makeup. What are your husbands genes? Since he is dx'd Celiac, if he doesnt have the 2 U.S. recognized Celiac genes, then it is a whole new ballgame for your children.

[wahmmy]

Nora is right. There are dx'd Celiacs with this genetic makeup. What are your husbands genes? Since he is dx'd Celiac, if he doesnt have the 2 U.S. recognized Celiac genes, then it is a whole new ballgame for your children.

His dr. didn't do a genetic test on him. They dx through I guess other blood work and also the biopsy. His numbers were really high in the blood work, but I know they didn't do a genetic test on him. He's going to see about getting it done now so insurance can pay for it and we won't have to do enterolab with him. Since the girls are so young, we felt the genetic test would be best to start with them and if they didn't have anything, it wouldn't be an issue. Enterolab said that was the way to go as well. Now I wish we would have gone ahead and done a full panel on them b/c now it seems we need to.

I'd just like to know about them for sure before we ban it completely for them outside the house. It's going to be a big deal to my oldest regarding school snacks, parties, etc. and I don't want to force her to take special food to those things if it's not an issue for her yet. Otherwise, we are moving toward a gluten-free home and he is completely gluten-free. All meals we eat with him are gluten-free.

[nora-n]

If they are on a low gluten diet, the tests probably will be inconclusive. You really have to eat a lo of gluten for a long time for the tests to be very positive for ordinary celiac.

We keep reading about people getting ill after going "healthy" and starting to bake whole wheat bread and eating whole wheat stuff. Also, the Italians have the highest incidence of celiac , they eat a lot of pasta...

The genes only explain half of celiac.

The highest risk is having a family member with celiac disease.....

nora