Jump to content

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

I Need Your Assistance To Understand My Results

Rockgurl

Recommended Posts

Rockgurl Rookie
Rockgurl
Posted

I got my results from Enterolab today and they are positive. However, I do not understand the whole gene DQ thing. Here are my results:

HLA-DQB1 Molecular analysis, Allele 1: 0302

HLA-DQB1 Molecular analysis, Allele 2: 0301

Serologic equivalent: HLA-DQ 3,3 (Subtype 8,7)

What does that make me? Am I DQ1? DQ3? I don't understand how to interpret them. Can you help?

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Lisa Mentor
Lisa
Posted
I got my results from Enterolab today and they are positive. However, I do not understand the whole gene DQ thing. Here are my results:

HLA-DQB1 Molecular analysis, Allele 1: 0302

HLA-DQB1 Molecular analysis, Allele 2: 0301

Serologic equivalent: HLA-DQ 3,3 (Subtype 8,7)

What does that make me? Am I DQ1? DQ3? I don't understand how to interpret them. Can you help?

Here is good, understandable information on gene testing (it can be very confusing):

Open Original Shared Link

Amyleigh0007 Enthusiast
Amyleigh0007
Posted

Is that all the information they sent you? I ordered the gene test today but I thought they would send an explanation along with the results. How long did it take to get the test and then get your results?

Rockgurl Rookie
Rockgurl
Posted
  • Author
Here is good, understandable information on gene testing (it can be very confusing):

Open Original Shared Link

Thanks for that. I have read it but am still none the wiser. Can anyone explain to me what I am?

Rockgurl Rookie
Rockgurl
Posted
  • Author
Is that all the information they sent you? I ordered the gene test today but I thought they would send an explanation along with the results. How long did it take to get the test and then get your results?

It took 2 weeks and 2 days. They sent me a detailed explnation but I still don't understand the gene/subtyping thing. This is what they gave me as an explanation:

Interpretation Of HLA-DQ Testing: HLA-DQB1 gene analysis reveals that you have one of the main genes that predisposes to gluten sensitivity and celiac sprue, HLA-DQB1*0201 or HLA-DQB1*0302. Each of your offspring has a 50% chance of receiving this gene from you, and at least one of your parents passed it to you. You also have a non-celiac gene predisposing to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201, or DQ3 not by HLA-DQB1*0302). Having one celiac gene and one gluten sensitive gene, means that each of your parents, and all of your children (if you have them) will possess at least one copy of a gluten sensitive gene. Having two copies also means there is an even stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease may be more severe.

I just want to know what DQ type I am.

Amyleigh0007 Enthusiast
Amyleigh0007
Posted

So if I am reading your results correctly (practice for when I get my daughter and my results) you have one gluten sensitivity gene and one Celiac gene? And, because you have these two genes you are more likely to develop Celiac? Do you think you have Celiac?

Rockgurl Rookie
Rockgurl
Posted
  • Author
So if I am reading your results correctly (practice for when I get my daughter and my results) you have one gluten sensitivity gene and one Celiac gene? And, because you have these two genes you are more likely to develop Celiac? Do you think you have Celiac?

I think so but I don't know. I'm having my Endoscopy on Monday but I have been wheat free (although not gluten-free) for about a year. I've been eating wheat for the past few weeks and I feel toxic!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Amyleigh0007 Enthusiast
Amyleigh0007
Posted

Yeah, that's why I'm doing the gene test for myself. I feel like it's just another part of the puzzle. I refuse to go back on gluten (I've been gluten free now for a year) so I can have an endoscopy. I wish the gene tests weren't so hard to read. Good luck on Monday!

gfb1 Rookie
gfb1
Posted
Yeah, that's why I'm doing the gene test for myself. I feel like it's just another part of the puzzle. I refuse to go back on gluten (I've been gluten free now for a year) so I can have an endoscopy. I wish the gene tests weren't so hard to read. Good luck on Monday!

imho, 'puzzle' is the correct word.

buried on p2 of the u.chicago celiac disease center publication:

In fact, up to one third of the U.S. population has the genes for celiac disease, but it is thought that only 1-4% of them will actually develop the disease at some point in their lifetimes.

it certainly puzzles me.

ravenwoodglass Mentor
ravenwoodglass
Posted
I got my results from Enterolab today and they are positive. However, I do not understand the whole gene DQ thing. Here are my results:

HLA-DQB1 Molecular analysis, Allele 1: 0302

HLA-DQB1 Molecular analysis, Allele 2: 0301

Serologic equivalent: HLA-DQ 3,3 (Subtype 8,7)

What does that make me? Am I DQ1? DQ3? I don't understand how to interpret them. Can you help?

You are a DQ8, one of the recognized celiac related genes and DQ7 the gluten sensitive one.

The US has finally started to recognize that there are more celiac related genes than used to be thought. For a long time if you were not DQ8 or DQ2 you would be told that you were not celiac if you live in the US. This is not the case in other countries where the total number of celiac related genes is more like 9.

It is confusing but the bottom line IMHO is that whether you are 'celiac' or intolerant the need to be gluten free is the same.

Rockgurl Rookie
Rockgurl
Posted
  • Author
You are a DQ8, one of the recognized celiac related genes and DQ7 the gluten sensitive one.

The US has finally started to recognize that there are more celiac related genes than used to be thought. For a long time if you were not DQ8 or DQ2 you would be told that you were not celiac if you live in the US. This is not the case in other countries where the total number of celiac related genes is more like 9.

It is confusing but the bottom line IMHO is that whether you are 'celiac' or intolerant the need to be gluten free is the same.

Thank you very much. I understand now. I appreciate your help. :)

Archived

This topic is now archived and is closed to further replies.

Go to topic listing

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate
  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Recent Activity

    1. Midwesteaglesfan
      - Midwesteaglesfan replied to Midwesteaglesfan's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Going for upper endoscopy today

      Back home after the scope. Dr said as soon as he got in there it was clear signs of celiacs. Must be a decent amount of damage. I don’t remember the post procedure conversation as the anesthesia was still wearing off but that’s what my wife says anyway. Still the biopsy results to come back but pretty definitive and now I get to learn to live gluten fre...
    2. Russ H
      - Russ H replied to Butch68's topic in Gluten-Free Foods, Products, Shopping & Medications
      4

      Guinness, can you drink it?

      There are several blogs where people test different beers using commercially available gluten testing kits. Guinness definitely tests positive for gluten. Something to be mindful of is that in some regions, foodstuffs containing less than 20 ppm gluten can be sold as 'gluten free'. However, due to the volume involved, a UK pint of beer at 19 ppm would contain...
    3. Scott Adams
      - Scott Adams replied to Borky's topic in Gluten-Free Foods, Products, Shopping & Medications
      1

      Gluten food test strips

      Welcome to the forum! Do you mean this article, and if so, I don't think these are available yet.
    4. Scott Adams
      - Scott Adams replied to Midwesteaglesfan's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      3

      Going for upper endoscopy today

      First of all, I want to wish you the very best of luck with your procedure today. It's completely understandable to feel a mix of apprehension and hope. Your proactiveness in researching and advocating for that endoscopy was incredibly smart; securing that formal diagnosis is crucial for both insurance and long-term health management. While it's natural to...
    5. Scott Adams
      - Scott Adams replied to Grace Good's topic in Gluten-Free Foods, Products, Shopping & Medications
      4

      Bee balm lipbalm not gluten free

      This article might be helpful:
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      132,269
    • Most Online (within 30 mins)
      7,748
    powergs03
    Newest Member
    powergs03
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.5k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • Midwesteaglesfan
      Going for upper endoscopy today

      By Midwesteaglesfan · Posted

      Back home after the scope.  Dr said as soon as he got in there it was clear signs of celiacs.  Must be a decent amount of damage.  I don’t remember the post procedure conversation as the anesthesia was still wearing off but that’s what my wife says anyway.  Still the biopsy results to come back but pretty definitive and now I get to learn to live gluten free
    • Russ H
      Guinness, can you drink it?

      By Russ H · Posted

      There are several blogs where people test different beers using commercially available gluten testing kits. Guinness definitely tests positive for gluten. Something to be mindful of is that in some regions, foodstuffs containing less than 20 ppm gluten can be sold as 'gluten free'. However, due to the volume involved, a UK pint of beer at 19 ppm would contain more gluten than the generally accepted as safe daily limit of 10 mg. I have seen gluten-free beers testing at between "undetectable" and 5-10 ppm. I have also seen a report of a positive home test on Daura Damm, which is sold as gluten-free beer - the manufacturer did not respond to the tester's query.
    • Scott Adams
      Gluten food test strips

      By Scott Adams · Posted

      Welcome to the forum! Do you mean this article, and if so, I don't think these are available yet.  
    • Scott Adams
      Going for upper endoscopy today

      By Scott Adams · Posted

      First of all, I want to wish you the very best of luck with your procedure today. It's completely understandable to feel a mix of apprehension and hope. Your proactiveness in researching and advocating for that endoscopy was incredibly smart; securing that formal diagnosis is crucial for both insurance and long-term health management. While it's natural to worry that those five gluten-free days could affect the results, your logic is spot-on—it's highly unlikely your intestines healed completely in that short time, and the fact that your joint pain and stomach issues have flared back up aggressively after reintroducing gluten is a very strong, and unfortunate, sign that the inflammation is indeed present and active. It's also very common for people to look back and connect dots, like your lifelong migraines, once a potential celiac diagnosis is on the table, as it's a systemic condition with many non-gastrointestinal symptoms. I truly hope this scope provides the clear answers you need to finally start on the right path to managing your health and finding lasting relief from the fatigue and pain. Safe travels for your drive, and here's hoping for a definitive answer and a brighter, healthier chapter ahead.
    • Scott Adams
      Bee balm lipbalm not gluten free

      By Scott Adams · Posted

      This article might be helpful:  
×
×
  • Create New...

Important Information

NOTICE: This site places This site places cookies on your device (Cookie settings). on your device. Continued use is acceptance of our Terms of Use, and Privacy Policy.