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Help Interpreting Blood Test!

MM5079

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MM5079 Rookie
MM5079
Posted

Hi, All!

I've read and read the site about the blood test, but I'm still a little confused. The nurse called me on the phone to tell me the results, but said everything so fast I couldn't process it well. He said that my anti-tissue transglutaminase (tTG-IgA) was 24 and the typical high is 19. He then said my endomysial was below the high raito of 1-10 or something to that effect! Either way, he said that my results do suggest Celiacs, and they will be doing a biopsy next week! Can anybody tell me if this test alone is indicitive of Celiacs? What's the percentage of a confirmed diagnosis of Celiacs of individuals with an anti-tissue transglutaminase (tTG-IgA) of 24?

I have an uncle with Celiacs, and finally gave in to his pressure for getting tested. I have been going though hell with GI issues. I hope this is finally an answer and my peripheral neuropathy will go away!

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ravenwoodglass Mentor
ravenwoodglass
Posted

You finally have your answer. When the tests are positive it is pretty certain that you are celiac. Even if the biopsy turns out to be a 'negative' you really should get on the diet. False negatives on both blood and biopsy are all too common.

MM5079 Rookie
MM5079
Posted
  • Author
You finally have your answer. When the tests are positive it is pretty certain that you are celiac. Even if the biopsy turns out to be a 'negative' you really should get on the diet. False negatives on both blood and biopsy are all too common.

It's almost too good to be true to finally know what's wrong with me. Should I continue eating Gluten until after the biopsy on the 23rd, or is it safe to go ahead and limit my intake as I've been doing?

psawyer Proficient
psawyer
Posted

If you are going to have a biopsy in the near future, I would recommend that you not change your diet until after the procedure. Next week is just days away. A high tTG-IgA is indicative of celiac disease, but a positive biopsy will confirm that celiac is indeed the cause.

My opinion, for what it is worth, is that once the endoscopy is done, I would adopt a gluten-free diet based on the tTG-IgA test alone.

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    • trents
      Disaccharide deficient, confusing biopsy results, no blood test

      By trents · Posted

      So the tTG-IGA at 28 is positive for celiac disease. There are some other medical conditions that can cause elevated tTG-IGA but this is unlikely. There are some people for whom the dairy protein casein can cause this but by far the most likely cause is celiac disease. Especially when your small bowel lining is "scalloped". Your Serum IGA 01 (aka, "total IGA") at 245 mg/dl is within normal range, indicating you are not IGA deficient. But I also think it would be wise to take your doctor's advice about the sucraid diet and avoiding dairy . . . at least until you experience healing and your gut has had a chance to heal, which can take around two years. After that, you can experiment with adding dairy back in and monitor symptoms. By the way, if you want the protein afforded by dairy but need to avoid casein, you can do so with whey protein powder. Whey is the other major protein in dairy.
    • jenniber
      Disaccharide deficient, confusing biopsy results, no blood test

      By jenniber · Posted

      hi, i want to say thank you to you and @trents   . after 2 phone calls to my GI, her office called me back to tell me that a blood test was “unnecessary” and that we should “follow the gold standard” and since my biopsy did not indicate celiac, to follow the no dairy and sucraid diet. i luckily have expendable income and made an appt for the labcorp blood test that day. i just got my results back and it indicates celiac disease i think 😭   im honestly happy bc now i KNOW and i can go gluten free. and i am SO MAD at this doctor for dismissing me for a simple blood test that wouldn’t have cost her anything !!!!!!!!!!! im sorry, im so emotional right now, i have been sick my whole life and never knew why, i feel so much better already   my results from labcorp:   Celiac Ab tTG TIgA w/Rflx Test Current Result and Flag Previous Result and Date Units Reference Interval t-Transglutaminase (tTG) IgA 01 28 High U/mL 0-3 Negative 0 - 3 Weak Positive 4 - 10 Positive >10 Tissue Transglutaminase (tTG) has been identified as the endomysial antigen. Studies have demonstrated that endomysial IgA antibodies have over 99% specificity for gluten sensitive enteropathy. Immunoglobulin A, Qn, Serum 01 245 mg/dL 87-352
    • JoJo0611
      Just diagnosed today

      By JoJo0611 · Posted

      Thank you this really helped. 
    • Samanthaeileen1
      Thoughts? Non-endoscopic Celiac diagnosis in two year old

      By Samanthaeileen1 · Posted

      Okay that is really good to know. So with that being positive and the other being high it makes sense she diagnosed her even without the endoscopy. So glad we caught it early. She had so many symptoms though that to me it was clear something was wrong.   yeah I think we had better test us and the other kids as well. 
    • GlorietaKaro
      Am I nuts?

      By GlorietaKaro · Posted

      One doctor suggested it, but then seemed irritated when I asked follow-up questions. Oh well—
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