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Undermythalted And Overmyethlated For Celiacs

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Histadelia (Undermethylation):

Histadelia indicates high levels of histamine in the blood stream (>70 mcg/dl). Histamine levels reflect a wide range of symptoms as there are histamine receptors in the skin, lungs, blood vessels and mucus membranes. High histamine can also cause some people to have psychological/behavioral symptoms as well.

This condition creates an imbalanced amino acid cycle, resulting in low serotonin levels. Obsessive compulsive patients are often histadeliacs. Often they are diagnosed with seasonal affective disorder. Other symptoms include perfectionism, allergies, headaches, and anorexia/bulimia.

Diagnosis is done primarily with a whole blood histamine level, folic acid and basophil levels.

Treatment revolves around antifolates such as methionine to add a methyl group to help histamine leave the body, calcium to release the excess histamine into the blood stream, and other supportive nutrients to help metabolism. It can take 3-6 months to resolve this chemical imbalance. If treatment is discontinued, then symptoms return.





Excess saliva



Easy tears

High libido

Addictive tendencies

Histapenia (overmethylation):

Histapenia is characterized by low blood histamine levels (<40 mcg/dl). The neurotransmitter dopamine tends to be high. About 1/3 of these patients experience anxiety disorders. They react badly to antihistamines and generally don’t have seasonal allergies, but have many food and chemical sensitivities.

Treatment revolves around folic acid, niacin, B12, and a high protein diet. Within 2-4 weeks gradual improvement is seen. It can take several months to truly correct this biochemical imbalance. As with all biochemical imbalances that are in born, if you stop treatment symptoms will return.


High anxiety, nervous

Social isolation

Academic underachievement

Dry eyes

Depression and despair

Food and chemical sensitivities

Low libido

Heavy body hair

Restless legs

Learning disabilities

Upper body or head pain

Panic attacks


No seasonal allergies

Increased dopamine and Norepinephrine

I have symptoms of both. Those who have high histamine SHOULD have low copper levels. I pretty positive that I have high copper levels.... HOWEVER folic acid messes my head up BAAAAD. That can only happen with high histamine levels which shouldn't be present with high copper levels (again, which i have). Sorry if i cant explain this very well. Basically my question is.... Is it possible that i have symptoms of both because of celiac disease? Perhaps what ever little histamine i have is being used in response to my constant gluten intake? I really appreciate yalls time to help.

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I had not heard of this before, but WOW do I fit the profile of being overmethylated/low histamine. It makes a lot of little things make sense--like the fact that when I saw a traditional allergist for food allergy testing, the nurse commented that during the skin testing I barely even reacted to the control substance, which EVERYONE is supposed to be allergic to. I was thinking low histamine even then, but didn't realize there was an entire syndrome that went with it.

I'm sorry I can't address your questions, but I think you may have just handed me a big clue to my own difficulties. Thank you SO much.

*off to do more research*

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Sorry to say that you just cannot have both Histadelia and Histapenia at the same time. Similarily you couldn't have hyper and hypo thyroidism at the same time, or have both high and low chloesterol levels at the same time. It doesn't work that way. If you have one, you don't have the other. I promise.

If you think you have something wrong with your histamine levels, go to the doctor and get blood tests for histamine levels and copper. Don't take an anti-histamine (all allergy medications are anti-histamines) before the test as these will reduce your histamine levels (so if you have high histamine or normal histamine your tests will come out all wrong).

The most common cause of high blood copper are not histadelia or histapenia, the cause is too many multi-vitamins (which contain copper) and/or drinking copper contaminated water -- usually from copper plumbing. You can reduce the copper containing multivitamins and drink bottled distilled water instead.

But don't change anything until you confirm high copper levels in your blood -- the symptoms of high copper are similar to about 100 other diseases and you just cannot diagnose yourself based on a list of random symptoms. I have many of the symptoms on the lists that you provided, and I'm positive I don't have a histamine or a copper problem. In fact, most of those symptoms are also symptoms of celiac disease -- which I assume you have based on your post. Therefore you probably have symptoms of both because they are also symptoms of untreated celiac disease. Perhaps you are still getting hidden sources of gluten in your diet and should try to figure out where the hidden gluten is coming from?

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Wheat allergy (as opposed to celiac disease) can cause high histamine levels, and can also cause similar symptoms to celiac disease, including vitamin deficiencies (such as folic acid).

The symptoms mentioned of both undermethylation and overmethylation are also symptoms of over-active and under-active thyroid, and may be related. However, celiac disease is already known to be linked with both over- and under-active thyroid autoimmune disease. There is also research from both India and Italy linking celiac disease with bipolar disorder as well.

I can't help wondering if these under- and over- methylation syndromes are symptoms of celiac disease, rather than stand-alone disorders.

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