Was Wondering About The Difference In B12 Methyl And The Cycl

[txplowgirl]

Am trying to understand the difference. I think I understand that the Methyl B-12( I would spell it but I would have to look it up, you guys out there understand) is better but i'm not sure why.

I am finally getting some relief with my ongoing fatigue after starting to take some stuff for adrenals with coQ10, Vit D, along with my B-12, magnesium, etc.

I guess I should just be patient, this has been ongoin since I was 7 or 8 so I know it's gonna take some time for the fatigue to go away. It's just been in the last 2 months that this has been starting to turn around. Everything else has gone pretty good this last year health wise other than being almost continuously glutened by my ex sweetie.

Anyway, I was thinking I needed to find some but I don't Know. So, Skylark, , what do you think?

[Skylark]

Methylcobalamin (or methyl-B12) is one of the two forms of B12 your body uses; adenosylcobalamin is the other. Vitamins often contain another natural form called cyanocobalamin that is cheap, stable, and absorbed reasonably well. Almost everybody can convert cyanocobalamin to the active forms. (There is a rare disorder where people can't convert B12 but it shows up early in life and has a LOT of symptoms.)

That said, there are a couple really old studies showing that methylcobalamin might be better retained and a little more effective for neuro problems. I take methylcobalamin for my B12 sublingual, figuring I may as well supplement with the exact form my body wants.

Now, folate is more interesting. Much like B12 folate is converted to L-methylfolate (5-methyltetrahydrofolate or 5-MTHF are other names) in the body. The interesting thing is that problems with converting folate appear to be somewhat more common than problems converting B12. People who don't convert folate well tend to have depression and other psych issues that improve when they take L-methylfolate instead of regular folic acid. I don't know about fatigue, as the studies are about schizophrenia and depression. The methylfolate manufacturing process is patented by Merck, who calls it Metafolin, and it is available as a prescription. It looks like right now Solgar has come to some agreement with Merck and is selling Metafolin as a supplement if you want to try it without a prescription.

[txplowgirl]

Thanks Skylark, I knew you could explain it where I could get my head around it. You are a wealth of info.

[Skylark]

I'm starting to think about collecting all this info into a book. It's just so much work.

[txplowgirl]

It would take a long time i'm sure, but it would be so worth it. Go For it!