Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Translation Needed

etta694

By etta694
in Publications & Publicity

Recommended Posts

etta694 Explorer
etta694
Posted

The following article talks about the difference between gluten sensitivity and Celiac but could someone please break it down a little? I think I get it but I want to make sure.

https://www.celiac.com/articles/22491/1/Study-Shows-Gluten-Sensitivity-and-Celiac-Disease-Clinically-Different/Page1.html

Just a quick break down of the last part...please?

(Does it mean that, with Celiac, the immune response is more along the lines of a response to, say, German Measles which is a 'permanent' response and continues - as opposed to gluten sensitivity which would be more of a temporary response that could, after time, subside?)

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


cassP Contributor
cassP
Posted

The following article talks about the difference between gluten sensitivity and Celiac but could someone please break it down a little? I think I get it but I want to make sure.

https://www.celiac.com/articles/22491/1/Study-Shows-Gluten-Sensitivity-and-Celiac-Disease-Clinically-Different/Page1.html

Just a quick break down of the last part...please?

(Does it mean that, with Celiac, the immune response is more along the lines of a response to, say, German Measles which is a 'permanent' response and continues - as opposed to gluten sensitivity which would be more of a temporary response that could, after time, reside?)

well that was very interesting! and a little complicated i agree. i didnt read about a temporary vs. permanent like u did- all i could understand was that one with Celiac would have more of a leaky gut- where has one with Gluten intolerance could have all the symptoms and inflammation- but no break in the gut barrier. and also there was a difference in the mucosal lining. that's all i could translate. very interesting. i wonder too if Zonulin (sp?) is something more associated with celiacs- and not present in gluten intolerants. isnt that a hormone or something that increases intestinal permeability??

this is so fascinating

etta694 Explorer
etta694
Posted
  • Author

'Zonulin is a protein that participates in tight junctions between cells of the wall of the digestive tract.'

Looked it up for this...I'm going back to read again.

I would like someone to give a monologue on this that I could understand.. ;) . Not being a researcher or biology major... I am not sure about the big picture.

psawyer Proficient
psawyer
Posted

I don't see anything there that would make me believe that gluten intolerance, whether celiac disease or not, would go away with time.

psawyer Proficient
psawyer
Posted

Research into the role that zonulin may play in the celiac disease response is ongoing. It appears that there may be possible way to prevent the autoimmune reaction. It will not change the underlying condition, but may treat the symptoms to the extent that the worries we have about being hurt by small amounts of gluten are no longer a concern. This is a controversial topic that has been discussed in several topics here.

Jestgar Rising Star
Jestgar
Posted
The study also supports the characterization of gluten sensitivity as a condition associated with prevalent gluten-induced activation of innate, rather than adaptive, immune responses in the absence of detectable changes in mucosal barrier function.

The innate immune system is the one that always responds the same. Not like a measles thing.

Takala Enthusiast
Takala
Posted

LOL at the one poster in that comment thread. "You're not a, and quit calling yourself that, but I am.... " paraphrased.

It probably never occurs to her that increasing the consumption pool of customers for gluten free foods, increases her potential for choice in selecting grocery and restaurant items to consume. From an anthropology standpoint, this may increase her chances of survival but does not seem to influence her attitude ....

_________

The study also supports the characterization of gluten sensitivity as a condition associated with prevalent gluten-induced activation of innate, rather than adaptive, immune responses in the absence of detectable changes in mucosal barrier function

wiki: innate immune system

defends host from infections, provide immediate defense, found in all classes of plant and animal life, evolutionary thought to be older form of basic defense system

Open Original Shared Link

wiki: adaptive immune system

"The adaptive immune response provides the vertebrate immune system with the ability to recognize and remember specific pathogens (to generate immunity), and to mount stronger attacks each time the pathogen is encountered. It is adaptive immunity because the body's immune system prepares itself for future challenges."

Open Original Shared Link

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


etta694 Explorer
etta694
Posted
  • Author

So actually, the innate response is a mute point when talking about Celiac because the body is ALWAYS going to respond for this condition (adaptive). The question of an innate response abating is for a gluten intolerant person and dependent on whether they are eating to heal their intolerance which would probably be due to leaky gut. By GOVE! I think I've GOT it!

It was that last part I was fuzzy on. (or am I still fuzzy.. :blink: Hope not...)

I know this has been chewed and spit out many times here and I am very appreciative of the longtime members who answer the same questions.. over and over.. and over.. and uber....

(It does bear fruit though...)

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      130,007
    • Most Online (within 30 mins)
      7,748
    Ellen Watts
    Newest Member
    Ellen Watts
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      121.3k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • wellthatsfun
      confirmed via biopsy, quite depressed

      By wellthatsfun · Posted

      i am australian. we do have plenty of substitutes, but most are very expensive compared to the originals. i believe i'll just stick to home cooked meals and not have many treats at all. it's sad but it's just so much easier. also, ive heard far too many horror stories of people ordering gluten free food from restaurants and cafés, explicitly telling servers and kitchen staff that cross contamination is a strict no go, and they still get very sick. until i find a reasonably priced fully gluten free kitchen somewhere, i am not eating out for my safety and sanity.
    • wellthatsfun
      confirmed via biopsy, quite depressed

      By wellthatsfun · Posted

      thank you all for the kind words and support. it truly means a lot. i know i will adapt, it really just is a grieving process right now though. looking forward to feeling healthier!
    • The Logician
      Gluten Sensitivity

      By The Logician · Posted

      To Trent’s, yes, from what i’ve read it is not uncommon for digestive systems to become less tolerant to gluten over time. Many types of sensitivity or allergies arise in older people who never had a problem. I don’t see why you are focusing on anything but the fact that after years of my sensitivity to gluten, for whatever reason , it has disappeared after a bout of antibiotics. What i’ve read is antibiotics can make gluten sensitivity worse. In any event, in my case, if I can still eat all the wheat products I want with no reaction after a month or more since my hospital stay this is something that should be investigated. Time will tell.
    • The Logician
      Gluten Sensitivity

      By The Logician · Posted

      I had a UTI, blood cultures are standard to insure that the infection does not get in the bloodstream which can lead to sepsis and death. In my case there was bacteria in my blood which necessitated 48 hours of antibiotic IV
    • Wends
      Finally got in to doctor to get my referral and I lucked out and got into Gastro the same day - question about different transglutaminase results

      By Wends · Posted

      Hi Cameo674. just read your post. Well wishes to a correct diagnosis so that you can get on track to healing and feeling better. Personally I know it’s good to have the eosinophilic disorder ruled out too, as this can show anti-ttg igA antibodies too. But usually without the anti-gliadin antibodies unless gliadin is an allergen for you. Thanks for posting the link to look up SNPs rs… numbers on another post. Was useful. Looking at your result, ”Celiac Associated HLD-DQ Typing: DQA1* Value: 05; DQA1*DQA11 Value: 05; DQB1* Value: 02; DQB1-DQB11 Value: 02; Celiac Gene Pairs Present Value: Yes; Celiac HLA Interpretation Value: These genes are permissive for celiac disease.  However, these genes can also be present in the normal population. Testing performed by SSOP.  So google failed me.  I think these results basically say I have genes, but everybody has these genes so this test was just to confirm that there is a vague possibility?  Maybe this test result explains why I do not have the horrible symptoms most individuals with celiac have?  I told the GI my assumption is that I am just gluten intolerant since I do not have the pain? So maybe this test explains why I have antibodies?” To me it reads.that you carry the high risk HLADQ2.5 haplotype.      
×
×
  • Create New...