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gfb1

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Celiac.com - Celiac Disease & Gluten-Free Diet Support Since 1995

Everything posted by gfb1

  1. gfb1
    holy crap. i hope anyone following this regimen is doing it under the advice and watchful eye of a physician. vitamin D is not a toy. it is a fat-soluble vitamin that can be dangerous. while 50,000iu/wk is not necessarily toxic -- it is approx 20% of dosages that have been found to show toxic effects. imo, that's way too close for comfort. this...
  2. gfb1
    thanks much; i have a good friend who is a nationally recognized mammary gland biologist... i'll sneak it by him for his opinion; mine follows... gliadin was found in ALL milk samples; but less than 1/2 serum samples. also, the striking increase in concentration of gliadin in milk might suggest that the mammary gland is concentrating gliadin.....
  3. gfb1
    is there any evidence for this?? certainly, the gliadin peptide (NOT gluten) is in the bloodstream; and without going into a treatise about mammary gland biology; i would be very surprised if gliadin found its way into the secretory process of milk production...
  4. gfb1
    knowing if you have a 'gene' is only helpful if you plan on reproducing..... and even then, there are only probabilities to be considered. unfortunately, most people (and this includes md's/do's/rd's/etc/etc/etc) are NOT trained to evaluate genetic risks (nor are they trained to predict the probability of occurrence in offspring). for example; you...
  5. gfb1
    i'm sure that you may think i'm splitting hairs; and that a few may be tiring of the tirade... but; the hla/dq haplotypes DO NOT CAUSE celiac disease. these are markers which often INFLUENCE the bodies immune response to particular antigens. also, please be very careful with self-medication with supplements/vitamins/etc. vitaminD toxicity is Open Original...
  6. gfb1
    it IS easy to blame celiac for everything... however, this is the way things go with diseases of the immune system (which, depending on your perspective, can be the primary cause or secondary symptomology of celiac disease). as another individual mentioned, as well as numerous threads in the forum, Open Original Shared Link can be associated with celiac...
  7. gfb1
    yes; it is incorrect -- as an absolute. diagnoses are ALWAYS a made by evaluating multiple test results and, obviously, patient examination. if anything was 100% accurate and predictive of ANY disease -- to paraphrase dr.house -- 'so, you're saying that medical school thing was a waste of time??' the EMA test itself is not 100% precise -- in that the...
  8. gfb1
    Open Original Shared Link, the converse does not follow either -- a negative EMA does not mean that you do NOT have celiac disease. as i, perhaps ineffectively, tried to explain -- a breakdown of the endomysium occurs anytime there is chronic damage of muscle fibers in the intestinal mucosa. these proteins enter the bloodstream and there is an immune response...
  9. gfb1
    this is not 100% correct. anti-endomysial antibodies can be found in patients with alcoholism, inflammatory bowel disease (non-celiac related) and after certain abdominal injuries/surgeries. indeed, these patients are usually EXCLUDED from studies showing the relationship between EMA and celiac disease. the endomysial tissue is proteinaceous connective...
  10. gfb1
    the reason for different ranges of results for different tests is due to different labs having different standard curves. there was a GREAT answer about how these test are done in another thread. now, imagine this complex process being repeated in different laboratories, by different people, with different equipment and different reagents at different...
  11. gfb1
    sorry... but, you need to say which blood tests. further, if you are experiencing bruising -- for which anemia is one of the easiest/most common reasons -- it was probably included in your first round of blood tests (whether blood iron, hemoglobin, transferrin, rbs's or just packed cell volume (pcv)). liver enzyme tests matter... ALT (alanine transaminase...
  12. gfb1
    well... tissue transglutaminase is a cytosolic enzyme that plays several roles in the body. ONE of which is its appearance as a diagnostic of celiac disease. ttg is also elevated in response to other types of tissue inflammatory processes and, sometimes, tumor formation. its job is to break down cross-linking of proteins, and does this in a variety of...
  13. gfb1
    how were your mom/sis diagnosed?? what blood tests?? what about your dad?
  14. gfb1
    just for fun; your pedigree is located Open Original Shared Link -- minus the 'aunt' whose relationship is not defined... you are the 'P' (00106), your dad is the '?' (00102). 'plus' signs indicate a postive test of some kind... part of the problem with diagnosis of celiac disease is an extremely variable age of expression. at least in part, this has...
  15. gfb1
    understood. its a question of terminology. you can have 1/2 a protein; partial functional elements, etc. but, NOT 1/2 a gene. 1/2 a gene is a non-functional gene. a haplotype is NOT half a gene... a haplotype is a pattern of alleles (or genes) in the human major histocompatibility complex (MHC) locus/loci, which defines which antigens are recognized...
  16. gfb1
    rwg has good advice (as usual)... please re-read the last sentence. i am often concerned about the effect of the 'on again, off again' gluten diets. since a large component of celiac disease is related to the bodies response to an antigen; i worry that cycling the diets INCREASES the chances of hyperresponsiveness to the gliadin/gluten antigen. think...
  17. gfb1
    this is a VERY interesting thread. so... has the work on mhc locus completely supplanted the concept of celiac as an inborn error of metabolism?? the nih does not say so directly... i Open Original Shared Link: however.. later the same article suggests an immune component/causation
  18. gfb1
    i had to laugh when i read your note! my wife's family as nearly 35 people among her first degree relatives and all but ONE have been tested for celiac (gliadin-ab, ttg-ab, endomyial-ab's, etc, etc AND upper gi series/biopsy). its a great pedigree; BUT her brother continues to refuse to be tested or try a gluten free diet -- even in the face of his wife...
  19. gfb1
    anything is 'possible' i suppose... however, antibodies interact with epitopes, which are short amino-acid sequences (usually 2-4 amino acids) contained in the proteins. a clustal analysis of the sequence of bovine casein and wheat gluten has a score of 12 -- which is the same score found between human hemoglobin and wheat gluten. this means that...
  20. gfb1
    what makes you think that casein and gluten are similar?? they are not. casein is from milk (read: animal protein -- and, in most food products, specifically cow's milk), while gluten is a plant protein found in some of the grasses (wheat, rye, barley). i seem to say this a lot in the forum; but, not to be mean-spirited or rude, but.... i'm not sure...
  21. gfb1
    i agree with rwg's advice. however, may have an additional suggestion. if you suspect that you have more than one food allergy/sensitivity then you (imho) you might try a systematic approach to your diet. start by going one week with a simple allergen-free diet. only rice/potatoes/banana. there are examples of this all over the place; and if you...
  22. gfb1
    i don't want to be mean-spirited... but, go find a real doctor in your area who has an interest/specialty in celiac disease. they exist. i am assuming that when you say you tested positive for gliadin-igg that this was a blood test. it is not unusual for celiacs to be positive for gliadin-igg and negative for gliadin-iga, as a significant percentage...
  23. gfb1
    'normal' is just a setting on the washing machine.. any 'normal' person would develop antibodies to gliadin, tissue transglutaminase (TTG) and casein (for that matter, bee stings and pork chops....) -- if those proteins were injected into their veins. the release of TTG is associated with the cell-death of intestinal enterocytes (and possibly other...
  24. gfb1
    'bone density'?? be very careful with measurements for bone density. there are a variety of ways that bone density can be estimated; however, these measurements change very slowly and have a fairly wide range of error. see Open Original Shared Link. btw -- even in elderly women, weight bearing exercise also significantly increases bone density (on the...
  25. gfb1
    not to be a stickler... but, you can't have "half a gene". on 2nd thought, i suppose you could --- but, then more than likely the gene would not be functional (see Open Original Shared Link). pet peeve alert: there is also NO such thing as a celiac gene; unless you are talking about some very early work implicating a glutaminase (probably/possibly a variant...
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