Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Test Results-What Do They Mean?
0

8 posts in this topic

I went to the Dr. for my yearly exam. While there she feels my stomach and starts asking about stomach issues, my heritage, ect. She says she wants to test me for Celiac. I have a high ANA and various other autoimmune symtoms (mouth sores, rashes, joint pain) and they haven't pinned down what could be causing all this yet. Well, the test came back and she strongly advises I start a gluten free diet. If symtoms don't improve in a month or so, I am to make an appointment with a GI. Below are my lab results. I am just wondering if there might be something else, but this seems to connect the dots and makes sense. And Celiac has been added to my health record as of now.

 

Immunoglobulin A 113 (standard range 81-426)

 

Gliadin IGA 19 (>10 positive)

 

Gliadin IGG 33 (>10 positive)

 

Tissue Transglutaminase IGA 83 (>10 positive)

 

Tissue Transglutaminase IGG 1 (>10 positive)

 

Thank you all in advance. If it is Celiac, I can tell this place will be a great resourse.

0

Share this post


Link to post
Share on other sites


Ads by Google:

did you get the endoscopy yet? if so do it before the diet change.

0

Share this post


Link to post
Share on other sites

Do not remove gluten just yet.

Those numbers clearly need referral to a gasterenterologist - preferably one with celiac experience - sadly not all GIs and Rhuematologists are experienced &/or up to date with current celiac research.

Welcome to the forum - be sure to read the newbie 101 thread and ask any questions you may have.

0

Share this post


Link to post
Share on other sites

Were your gliadin test results "anti-gliadin" or "deamidated gliadin"? Anti-gliadin does not differentiate between autoimmune and non-autoimmune forms of gluten intolerance. That means that both Celiac and non-Celiac Gluten Intolerance as well as some "healthy" population samples will show up positive on the result while the deamidated is pretty specific to the autoimmune form, aka Celiac. 
 

0

Share this post


Link to post
Share on other sites

Thank you all for the responses. I don't know whether the gliadin was "anti-glliandin" or "demitdated gliadin". I have already slowing started to eat gluten free and have cleaned out my pantry. My GP says I most likely have Celiac, she will refer me to GI should my symptoms continue, as of now she is treating me to have Celiac. I am fine with the diagnosis and have accepted it as it really does connect so many dots. My stomach always "hates life" as I put it. It's never been happy, but I've always thought it was normal. Now I know it's not. I am just trying to understand what each test means in regards to Celiac.

0

Share this post


Link to post
Share on other sites




The Tissue Transglutaminase is the one test that the doctors mostly rely upon, which measures antibodies made in the small intestine.  While not completely specific for celiac disease, celiac is the most likely cause and your result was quite high.  If the Gliadin IgA was the Deamidated Gliadin Peptide(DGP) (which was also quite positive), then those two results in combination would put you pretty squarely celiac, because the DGP is very specific for celiac disease and you make sufficient quantities of IgA for the IgA testing to be valid for you (Immunoglobulin A).  However, if it was the AGA IgA, this is an outdated test not used much any more because it's not very reliable.

0

Share this post


Link to post
Share on other sites

HI,

 

Your bodies immune system makes a variety of different types of antibodie cells.  IgA, IgG, IgE etc.  You can have a positive result on one type of antibodie but not on another.  But they all do damage to the gut if you have a celiac auto-immune response.  Basically, the immune cells attack your own tissue, instead of an outside invader.  That is what they mean by an auto-immune disease.

0

Share this post


Link to post
Share on other sites

Thank you all. At this point, my doctor is considering my diagnosed. Right now it seems a bit intimidating but I am sure that will lessen over time. I am hopeful that a gluten free diet will solve many of my auto-immune issues that I have and that doctors haven't pinpointed what the cause was (until now). Thank you all.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,120
    • Total Posts
      919,468
  • Topics

  • Posts

    • Hi Alok, I suggest not eating any soy.  Soy is one of the top 8 food allergens in the USA.  Soy has other things about it that are not helpful to us.  Plus it is often sprayed with pesticides that are not so great for people.  Maybe you can try some other food for a while?  Also it might help to wash all your vegetables before using them. Just some ideas, I hope they help.
    • What she said!     The antibody panel is an important part of follow-up!
    • I have Celiac, Hashi's thyroid disease, Sjogren's Syndrome and Reynaud's Syndrome.  All have gotten better, inflammation wise, after 11 years gluten free.  I am very strict with my diet, never take chances if I feel the food is not really gluten free and limit the number of times I go out to eat.  I am not saying I never go out but it is normal for my husband and I to not see the inside of a restaurant for 3-4 months at a time and then I only eat at the places that have never glutened me.  I am lucky in that the state I live in has 3 restaurant chains that are run/owned by Celiac's, so they get it right every time. You have not been gluten free for very long, in reality.  It took me three years to completely rid myself of all symptoms related to the disease.  I was 46 at the time of diagnosis.  I know it is hard to accept that healing can take that long but you have to measure it differently.  Looking back, you should feel better than you did a year ago.  As time goes on, healing slowly takes place until you realize that certain problems have disappeared.  It is not as cut and dried as taking an antibiotic for an infection. http://www.drweil.com/drw/u/ART03424/Elevated-Creactive-Protein-CRP.html  Read this article on elevated c reactive protein. It is by Dr. Weil, who is a Harvard trained physician who chose to go the more natural route to healing people.  All his stuff is interesting.  Yes, your elevated level will most likely come down, as you heal better.  Pay attention to it but don't let it freak you out too much! 
    • Hi Calla, I think the safe answer is 12 weeks on gluten for a blood test.  I am pretty sure they say 2 weeks on gluten for the gut endoscopy.  But usually people/doctors don't want to  do an endoscopy before a positive blood test, so catch 22 there. There's a chance you still have active antibodies in your blood after 3 weeks off gluten.  But nobody can tell you for sure.  If you can get you doctor to test you now and in 9 more weeks if you are negative now, that might work.  If the doctor is willing to do 2 tests, that would be great. The best thing would have been to do all celiac disease testing before going gluten-free.  But sometimes it doesn't work out that way. The University of Chicago celiac center has an FAQ that answers some of your questions. http://www.cureceliacdisease.org/faq/i-dont-have-the-money-to-get-tested-for-celiac-disease-but-a-gluten-free-diet-makes-me-feel-better-is-it-okay-to-start-the-diet-without-being-diagnosed/ Welcome to the forum!  
    • Couldn't have said it better!  
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,159
    • Most Online
      1,763

    Newest Member
    Anns
    Joined