Here are the tests that are currently used in the medical community to diagnose Celiac Disease:
- Tissue Transglutaminase Antibodies (tTG-IgA, tTG-IgG)
- Anti-Gliadin Antibodies (AGA-IgA, AGA-IgG)
- Anti-Endomysial Antibodies (EMA-IgA, EMA-IgG)
- Deamidated Gliadin Peptide Antibodies (DGP-IgA, DGP-IgA)
- Total IgA count
Deamidated Gliadin Peptide Antibody IgA:
0-19 is defined as normal
Deamidated Gliadin Peptide Antibody IgG:
0-19 is defined as normal
Tissue Transglutaminase Antibody IgA:
0-3 is defined as normal
Tissue Transglutaminase Antibody IgG:
0-5 is defined as normal
Total IgA Antibody count:
70-400 is defined as normal
Let’s try and define “normal.” What does “normal” mean? Does this mean that people who are perfectly healthy, who are having no reaction to gluten at all, have those numbers? Or does it just mean that people who may be having a reaction to gluten, but not enough to cause villous atrophy, may have those numbers?
I especially find “weak positive” vs “positive” to be hilarious. What does “weak positive” mean? I mean, come on! Does “weak positive” mean they THINK it might cause villous atrophy?
I suppose that scientists and/or doctors have arrived at these numbers as their definition of what (they think) is (maybe) going to cause villous atrophy. However, there are many questions and doubts I have about this, as follows:
1. How do they know that these numbers will or will not cause villous atrophy? What if a DGP IgA value of 15 causes villous atrophy in some people whereas a number of 21 does not cause villous atrophy in others?
2. What if the guy with the 21 number does not have villous atrophy yet because his body only started reacting to gliadin proteins a few months ago and not enough time has passed to develop villous atrophy?
3. Is villous atrophy all we care about? What other forms of damage can a DGP-IgA value of 20+ be doing? What about a value of 15? 10? 5? 1 even?
4. If you have a number greater than 0 of any of these SELF antibodies, doesn’t that mean you have a form of autoimmune disorder? If not, then does the body just make these antibodies just because it feels like it? Is the human body programmed by evolution to make at least a certain amount of these self antibodies (I seriously doubt it), or does it make them in response to stimuli?
5. If the latter, can the stimuli be anything besides gliadin and glutenin proteins? If so, what?
My theory: if your body is making ANY antibodies against SELF tissues, you have an autoimmune disorder, but I don't know what is causing it, nor can I tell you what type of damage it is doing to your body. I know, that's very helpful, isn't it?
What do you guys think?