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  • Jefferson Adams

    Can Antigliadin IgA Testing Spot Psoriasis Patients Likely to Benefit from a Gluten-free Diet?

    Jefferson Adams


    Reviewed and edited by a celiac disease expert.

      Psoriasis patients who do not have celiac disease or non-celiac gluten sensitivity commonly show high levels of antigliadin IgA antibody.


    Caption: Can Antigliadin IgA Testing Spot Patients Likely to Benefit from a Gluten-free diet? Photo: CC--galiciandreamer

    Celiac.com 01/30/2018 - Numerous clinicians have reported higher levels of celiac disease markers in their patients with psoriasis. A number of researchers believe that some psoriasis patients suffer from asymptomatic celiac disease, and a number of patients have reported symptom improvements with gluten-free diets.

    A team of researchers recently set out to determine the prevalence of antigliadin IgA antibodies in psoriasis vulgaris, and to assess the response of seropositive patients to a gluten-free diet.



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    The research team included Nikolai A Kolchak, Maria K Tetarnikova, Maria S Theodoropoulou, Alexandra P Michalopoulou, and Demetrios S Theodoropoulos. They are variously affiliated with the Department of Hematology, Omsk State Medical Academy, Omsk, Russia; Dermatology Private Practice, Chelyabinsk, Russia; Department of Pharmacy, Trikala General Hospital, Trikala, Greece; Department of Philosophy and Social Studies, School of Philosophy, University of Crete, Rethymnon, Greece; and Allergy Associates of La Crosse, Onalaska, WI, USA.

    The team assessed the prevalence of gliadin IgA antibodies among patients with psoriasis in an urban population, along with noting the clinical effects of a strict gluten-free diet.

    The team recruited 97 patients with Psoriasis Area and Severity Index greater than 2.4 from a dermatology clinic. They measured gliadin IgA antibodies in all participants and in 91 control subjects. They found elevated gliadin IgA antibodies in 13 patients, and two controls. All 13 patients were placed on a strict gluten-free diet without any other modifications in their ongoing treatment of psoriasis.

    Psoriasis patients who do not have celiac disease or non-celiac gluten sensitivity commonly show high levels of antigliadin IgA antibody.

    These results show that antigliadin IgA testing can identify psoriasis patients likely to benefit from a gluten-free diet.

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  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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