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  • Scott Adams

    Celiac Disease Patients Show Higher Rates of Psychiatric Disorders

    Scott Adams

    By Scott Adams •

    2 2
    Reviewed and edited by a celiac disease expert.

      A large database study shows that celiac patients have a higher risk of having multiple psychiatric diseases including anxiety, depression, bipolar, ADHD, eating disorder, and autism.


    Image: CC BY-SA 2.0--Fey Ilyas
    Caption: Image: CC BY-SA 2.0--Fey Ilyas

    Celiac.com 02/15/2021 - A number of studies have tied celiac disease to psychiatric disorders, but there is still not much good data to support the connection. To get a better picture of the issue, a team of researchers recently set out to describe the epidemiology of several psychiatric disorders in celiac disease.

    The research team included Motasem Alkhayyat, Thabet Qapaja, Manik Aggarwal, Ashraf Almomani,  Mohammad Abureesh, Omaymah Al‐otoom, Mohammad Zmaili, Emad Mansoor, and Mohannad Abou Saleh.


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    They are variously affiliated with the Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic Foundation, Cleveland, Ohio; the Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio; the Department of Gastroenterology, University Hospitals Cleveland Medical Center, Cleveland, Ohio; the Department of Internal Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio; University of Jordan Medical School, University of Jordan, Amman, Jordan; and Department of Internal Medicine, Staten Island University Hospital, New York City, New York.

    For their study, the team used a multi‐center database, called Explorys Inc, which offers electronic health record data from 26 major integrated healthcare systems consisting of 360 hospitals in the US. Of the 3,746,581 patients in the database between 2016‐2020, there were 112,340 patients with celiac disease. 

    The team identified a group with celiac disease using the Systematized Nomenclature Of Medicine ‐ Clinical Terms (SNOMED–CT). They then conducted multivariate analysis using SPSS version 25. 

    Compared to patients with no history of celiac disease, celiac patients were more likely to have a history of anxiety, depression, bipolar, ADHD, eating disorder, and autistic disorder. Patients with celiac disease and psychiatric conditions were more likely to be smokers, and to have a history of alcohol and substance abuse , along with a history of personality disorder.

    This large database study shows that celiac patients have a higher risk of having multiple psychiatric diseases including anxiety, depression, bipolar, ADHD, eating disorder, and autism. 

    The team advises clinicians to keep mental health in mind when treating celiac patients, and to make psychiatric referrals as needed.

    Read more in Gastroenterology

    Edited by Scott Adams

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    Guest celiac Dx 2005

    Guest celiac Dx 2005

    Posted

    Maybe the psych disorders are sequelae from years and years of enduring every gastro test under the sun before being (blessedly, finally) DXed with something so simply fixed as Celiac Disease. I cannot tell you how many horrid tests I endured before diagnosis... And EVEN AFTER diagnosis because the Doc wouldn't believe the diagnosis! 

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    Guest Guest too

    Wondering if this observation applies to other autoimmune diseases? neuroinflammation is common for all autoimmune diseases and mental disorders mentioned in the study above.

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    Guest Celiac dx 2002

    Maybe a subset of these psychiatric disorders are autoimmune themselves. I received my COVID-19 vaccine recently. After the second dose, my immune system seemed to be activated with the expected side effects of malaise and fatigue. However, I also noticed that I felt very sad (a deep emptiness that I have never experienced before) for a day or so. That made me wonder about the connection between immune system activation and depression.

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    trents
    1 hour ago, Guest Celiac dx 2002 said:

    Maybe a subset of these psychiatric disorders are autoimmune themselves. I received my COVID-19 vaccine recently. After the second dose, my immune system seemed to be activated with the expected side effects of malaise and fatigue. However, I also noticed that I felt very sad (a deep emptiness that I have never experienced before) for a day or so. That made me wonder about the connection between immune system activation and depression.

    An interesting hypotheses indeed. Haven't seen any research to that effect but all knowledge has a starting point.

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    knitty kitty

    High levels of histamine have been found in the brains of people with psychiatric disorders.  

    High histamine and mast cell activation syndrome has been found in Celiac Disease.

    Vitamin and nutritional deficiencies have effects on the brain.

     

    Bread and Other Edible Agents of Mental Disease

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809873/#!po=18.0556

     

    Histamine in neurotransmission and brain diseases

    https://pubmed.ncbi.nlm.nih.gov/21618891/

     

    Vitamin Supplementation in the Treatment of Schizophrenia

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083629/

     

    3 hours ago, Guest Celiac dx 2002 said:

    Maybe a subset of these psychiatric disorders are autoimmune themselves. I received my COVID-19 vaccine recently. After the second dose, my immune system seemed to be activated with the expected side effects of malaise and fatigue. However, I also noticed that I felt very sad (a deep emptiness that I have never experienced before) for a day or so. That made me wonder about the connection between immune system activation and depression.

    Thiamine deficiency can be precipitated by vaccines.  Thiamine supplementation will alleviate the fatigue and depression.  Work up to 300 mg a day.  

    Hope this helps.

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    Guest Deborah N

    My doctor at OSU, Dr. Aukerman, indicated that celiac has a severe impact on magnesium levels. He displayed a poster that showed the downward spiral from headaches to depression to suicide. He put his patients on high doses of magnesium. I found that once my celiac was diagnosed (which took 50 years!), and I was taking magnesium, I was far less prone to depression and anxiety.

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    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.

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