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The Celiac Disease - Depression Connection 03/15/2008 - For the first time, medical researchers have shown that an activation of the inflammatory response system accompanies major depression and that pro-inflammatory cytokines and lipopolysaccharide (LPS) may trigger symptoms of depression. In the face of the study results, researchers are recommending that patients with depression be screened for leaky gut using IgM and IgA panels.

Researchers set out to determine the role played by increased gastrointestinal permeability coupled with an increased translocation of LPS from gram-negative bacteria in the pathophysiology of major depression (MDD). The researcher team was made up of M. Maes, M. Kubera, J.C. Leunis. The team created a study to evaluate serum levels of IgM and IgA against LPS of the gram-negative enterobacteria Hafnia Alvei, Pseudomonas Aeruginosa, Morganella Morganii, Pseudomonas Putida, Citrobacter Koseri, and Klebsielle Pneumoniae in MDD patients and normal controls.

Compared to the non-depressive control groups, patients with major depression (MDD) showed significantly greater prevalences and median values for serum IgM and IgA against LPS of enterobacteria. Increased levels of IgM and IgA are associated with fatigue, autonomic and gastro-intestinal symptoms and a subjective feeling of infection.

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Leaky Gut a Factor in Major Depression

The results demonstrate that intestinal mucosal dysfunction marked by an elevated translocation of gram-negative bacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression.

Researchers are suggesting that IgM and IgA panels be used to screen people who suffer from depression for leaky gut.

Neuro Endocrinol Lett. 2008 Feb;29(1):117-24. welcomes your comments below (registration is NOT required).

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7 Responses:

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said this on
18 Mar 2008 7:39:43 AM PST
This is a great article.

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said this on
21 Mar 2008 1:07:39 PM PST
Would it be advisable then, that all people suffering from major depression be put on strict gluten free diets? Perhaps even in the mental hospitals, it may be helpful to observe gluten free diets for those with bloated abdomens.

geo kozmosz

said this on
13 Jun 2008 5:03:07 AM PST
I used to have an extreme fatigue for all my life at midday and was treated with bipolar (borderline, manic depressive) sickness for years (by drugs). Now I do not use medicines and I do not have the extreme fatigue--simply by following this gluten-free diet.

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said this on
14 Dec 2008 7:38:02 PM PST
This was a great article, although I was hoping for something a bit more in depth.

In response to #2, I'm not a doctor, but from what I've read about Celiac disease, and a gluten free diet, it isn't wise to do it unless you are certain that it is celiac disease. I suffer from depression, and I'm now getting tested for Celiac disease. I think it may be a wise decision to get tested for celiac disease if you have depression and stomach problems that accompany it. I've always felt that there was more to my stomach problems then what the doctors were thinking. Trust your gut instinct when it comes to things like that. You know your body better then anyone, including doctors.

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said this on
11 Jan 2012 5:15:34 PM PST
I was diagnosed as bipolar (?). Self-diagnosed celiac via 3 years testing: gluten/no gluten. BUT...just because a food/product is gluten free does not mean it is GOOD for your body. Other chemicals, gluten free, are NOT safe to consume. Cosmetics/hair color/soaps are sneaky gluten carriers. I find it virtually impossible to live gluten free and happy! Forget looking your best, sharing dinners, having the energy for vacations. It is scary and sad and a very ALONE disease.

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said this on
20 Jun 2009 1:53:13 PM PST
I was diagnosed with bipolar disorder after a suicide attempt 4.5 years ago. Since then and until last October I had been on medications to control it. I suddenly became allergic to the medications, then extraordinarily sick and was finally diagnosed (after a 6 month period of trial and error by the doctors) with celiac. I had to come off of my medications, but after beginning a gluten free diet I didn't need them anymore. Post diet I have had more energy and mental clarity than ever in my life and have not needed another drug to control my moods or help with depression. The bipolar symptoms are simply gone. Amazing.

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said this on
03 Nov 2010 6:34:51 AM PST
While this article has some tiny amount of fact presentation, it is so brief and devoid of any discussion or conclusions so as to make it pretty useless for advice, let alone self-help.

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